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Found 789 with Last Name = 'coxon' and Initial = 'a'
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17689(2-aminobenzimidazole, 14 | N-{4-chloro-3-[(4-methy...)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17704(2-aminobenzoxazole, 29 | N-(4-chloro-3-{[(2S)-1-me...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17705(2-aminobenzoxazole, 30 | N-{4-chloro-3-[(4-methylp...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17703(2-aminobenzoxazole, 28 | N-(4-chloro-3-{[(2S)-1-me...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17687(2-aminobenzimidazole, 12 | N-(3-{[(2R)-1-methylpyr...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17709(2-aminobenzoxazole, 34 | N-(4-chloro-3-{[(2S)-1-me...)
Affinity DataKi:  1.60nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222499(CHEMBL401153 | N-(3-chlorophenyl)-2-(pyridin-4-ylm...)
Affinity DataKi:  2nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17684(2-aminobenzimidazole, 9 | N-methyl-4-({2-[(3-{[(2R...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17710(2-aminobenzoxazole, 35 | N-{4-chloro-3-[(4-methylp...)
Affinity DataKi:  2nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17713(2-aminobenzoxazole, 38 | 7-chloro-N-{4-chloro-3-[(...)
Affinity DataKi:  2nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17688(2-aminobenzimidazole, 13 | N-{4-chloro-3-[(4-methy...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222500(CHEMBL250482 | N-(4-cyclohexylphenyl)-2-(pyridin-4...)
Affinity DataKi:  2nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17697(2-aminobenzoxazole, 22 | 4-({2-[(4-chloro-3-{[(2S)...)
Affinity DataKi:  2.80nM ΔG°:  -48.3kJ/mole IC50:  4.60nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17683(2-aminobenzimidazole, 8 | 4-{[2-({3-[2-(dimethylam...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17702(2-aminobenzoxazole, 27 | 4-({2-[(4-chloro-3-{[(2S)...)
Affinity DataKi:  3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17691(2-aminobenzimidazole, 16 | N-{4-chloro-3-[(4-methy...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17711(2-aminobenzoxazole, 36 | 4-({2-[(4-chloro-3-{[(2S)...)
Affinity DataKi:  3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17701(2-aminobenzoxazole, 26 | 4-[(2-{[4-chloro-3-(piper...)
Affinity DataKi:  3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24772(2-[(4-fluorophenyl)amino]-5-[5-({6-methoxy-7-[3-(m...)
Affinity DataKi:  3.40nM ΔG°:  -47.8kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17706(2-aminobenzoxazole, 31 | N-{4-chloro-3-[(4-methylp...)
Affinity DataKi:  3.60nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17682(2-aminobenzimidazole, 7 | 4-{[2-({4-chloro-3-[(4-m...)
Affinity DataKi:  3.90nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222501(CHEMBL250684 | N-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataKi:  4nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17695(2-aminobenzoxazole, 20 | 4-{[2-({4-chloro-3-[(4-me...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17700(2-aminobenzoxazole, 25 | 4-[(2-{[4-chloro-3-(morph...)
Affinity DataKi:  4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17698(2-aminobenzoxazole, 23 | 4-{[2-({4-chloro-3-[2-(di...)
Affinity DataKi:  4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24769(5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...)
Affinity DataKi:  4.90nM ΔG°:  -47.0kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17699(2-aminobenzoxazole, 24 | 4-{[2-({4-chloro-3-[2-(di...)
Affinity DataKi:  5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222509(CHEMBL250228 | N-(4-chlorophenyl)-2-(pyridin-4-ylm...)
Affinity DataKi:  8nMAssay Description:Inhibition of unphosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17680(2-aminobenzimidazole, 5 | N-(4-chlorophenyl)-5-[(6...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222498(CHEMBL400512 | N-(3,5-bis(trifluoromethyl)phenyl)-...)
Affinity DataKi:  8nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24751(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin...)
Affinity DataKi:  8.90nM ΔG°:  -45.5kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17685(2-aminobenzimidazole, 10 | N-methyl-4-({2-[(3-{[(2...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222512(2-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Affinity DataKi:  9nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17678(2-aminobenzimidazole, 3 | 4-[(2-{[4-chloro-3-(trif...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24754(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(4-methylp...)
Affinity DataKi:  9.20nM ΔG°:  -45.4kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24764(5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...)
Affinity DataKi:  9.60nM ΔG°:  -45.3kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17694(2-aminobenzimidazole, 19 | 4-{[2-({4-chloro-3-[(4-...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM15019(CHEMBL385178 | N-(4-phenoxyphenyl)-2-[(pyridin-4-y...)
Affinity DataKi:  10nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17712(2-aminobenzoxazole, 37 | 4-{[7-chloro-2-({4-chloro...)
Affinity DataKi:  10nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17696(2-aminobenzoxazole, 21 | 4-({2-[(4-chlorophenyl)am...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24752(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(pyrrolidi...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24768(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50132151(CHEMBL101683 | N-(4-Chloro-phenyl)-2-[(pyridin-4-y...)
Affinity DataKi:  15nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24765(5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222513(CHEMBL248781 | N-(3,4-dichlorophenyl)-2-(pyridin-4...)
Affinity DataKi:  17nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17690(2-aminobenzimidazole, 15 | N-{4-chloro-3-[(4-methy...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222516(CHEMBL400140 | N-(4-butylphenyl)-2-(pyridin-4-ylme...)
Affinity DataKi:  19nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17708(2-aminobenzoxazole, 33 | N-{4-chloro-3-[(4-methylp...)
Affinity DataKi:  20nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24755(2-benzyl-5-[4-({7-[3-(4-ethylpiperazin-1-yl)propox...)
Affinity DataKi:  21nM ΔG°:  -43.4kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222503(CHEMBL248976 | N-biphenyl-4-yl-2-[(pyridin-4-ylmet...)
Affinity DataKi:  23nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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