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Found 163 with Last Name = 'cunningham' and Initial = 'br'
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tyrosine kinase 2 kinaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)
Affinity DataIC50:  1nMAssay Description:Inhibition of protein kinase Jak 2More data for this Ligand-Target Pair
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289286(((R)-1-{(S)-1-[(S)-1-((S)-1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50079824(((S)-1-{(S)-1-[(S)-(S)-1-(1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)
Affinity DataIC50:  5nMAssay Description:Inhibition of protein kinase Jak 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289247((S)-2-((S)-3-Carbamoyl-2-{(S)-2-[((R)-2-ethoxycarb...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289278((S)-2-[(S)-3-Carbamoyl-2-((S)-2-{[(R)-2-ethoxycarb...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289286(((R)-1-{(S)-1-[(S)-1-((S)-1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  9.90nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289276((1-{2-Methyl-1-[1-(2-oxo-azepan-3-ylcarbamoyl)-eth...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase JAK1(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)
Affinity DataIC50:  15nMAssay Description:Inhibition of murine Jak 1 protein kinaseMore data for this Ligand-Target Pair
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289258((S)-2-((S)-3-Carbamoyl-2-{(S)-2-[((R)-2-ethoxycarb...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289258((S)-2-((S)-3-Carbamoyl-2-{(S)-2-[((R)-2-ethoxycarb...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50079824(((S)-1-{(S)-1-[(S)-(S)-1-(1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289272(CHEMBL80597 | [(R)-1-{(S)-1-[(S)-1-((S)-1-Carbamoy...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289271(CHEMBL77558 | [(R)-1-{(S)-1-[(S)-1-((S)-1-Carbamoy...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289252((S)-2-((S)-2-{(S)-2-[(S)-2-(3-Ethyl-ureido)-3-phen...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289267(((R)-2-Benzo[b]thiophen-3-yl-1-{(S)-1-[(S)-1-((S)-...)
Affinity DataIC50:  23nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289264((S)-4-Methyl-2-((S)-2-{(S)-3-methyl-2-[(S)-2-(4-ox...)
Affinity DataIC50:  25nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289275(((S)-1-{(S)-1-[(S)-1-((S)-1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  28nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289265((S)-2-[(S)-3-Carbamoyl-2-((S)-2-{[(R)-2-ethoxycarb...)
Affinity DataIC50:  31nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289279(((S)-1-{(S)-1-[(S)-1-((S)-1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  32nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289247((S)-2-((S)-3-Carbamoyl-2-{(S)-2-[((R)-2-ethoxycarb...)
Affinity DataIC50:  35nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8509((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-4-(...)
Affinity DataIC50:  37nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8513((2R)-5-[(aminiumylmethanimidoyl)amino]-2-[(4-fluor...)
Affinity DataIC50:  40nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8501((2R)-2-cyclohexyl-2-[(4-fluoro-3-methylbenzene)sul...)
Affinity DataIC50:  42nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289257(((S)-1-{(S)-1-[(S)-1-((S)-1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  43nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289261(Acetic acid ((S)-1-{(S)-1-[(S)-1-((S)-1-carbamoyl-...)
Affinity DataIC50:  46nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289280(CHEMBL309641 | [(R)-1-{(S)-1-[(S)-1-((S)-1-Carbamo...)
Affinity DataIC50:  46nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8512((2R)-3-(2-aminiumylethoxy)-2-[(4-fluoro-3-methylbe...)
Affinity DataIC50:  48nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8502((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-h...)
Affinity DataIC50:  50nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8507((2R)-3-cyclopropyl-2-[(4-fluoro-3-methylbenzene)su...)
Affinity DataIC50:  51nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8503((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-h...)
Affinity DataIC50:  54nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8511((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-4-(...)
Affinity DataIC50:  57nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8510((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-4-[...)
Affinity DataIC50:  59nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289278((S)-2-[(S)-3-Carbamoyl-2-((S)-2-{[(R)-2-ethoxycarb...)
Affinity DataIC50:  63nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8500((2R)-2-cyclopentyl-2-[(4-fluoro-3-methylbenzene)su...)
Affinity DataIC50:  64nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8508((2R,3S)-3-cyclopropyl-2-[(4-fluoro-3-methylbenzene...)
Affinity DataIC50:  65nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8506((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-h...)
Affinity DataIC50:  67nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8505((2R,3S)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-...)
Affinity DataIC50:  67nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289248(((S)-1-{(S)-5-Amino-1-[(S)-1-((S)-1-carbamoyl-3-me...)
Affinity DataIC50:  67nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8496((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-h...)
Affinity DataIC50:  70nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289271(CHEMBL77558 | [(R)-1-{(S)-1-[(S)-1-((S)-1-Carbamoy...)
Affinity DataIC50:  73nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8514(4-[(3R)-3-[(4-fluoro-3-methylbenzene)sulfonamido]-...)
Affinity DataIC50:  75nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289272(CHEMBL80597 | [(R)-1-{(S)-1-[(S)-1-((S)-1-Carbamoy...)
Affinity DataIC50:  75nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289269(((S)-1-{(S)-5-Amino-1-[(S)-1-((S)-1-carbamoyl-pent...)
Affinity DataIC50:  81nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289289((S)-2-((S)-2-{(S)-2-[(S)-2-(2-Acetylamino-acetylam...)
Affinity DataIC50:  81nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289276((1-{2-Methyl-1-[1-(2-oxo-azepan-3-ylcarbamoyl)-eth...)
Affinity DataIC50:  82nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289267(((R)-2-Benzo[b]thiophen-3-yl-1-{(S)-1-[(S)-1-((S)-...)
Affinity DataIC50:  85nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8495((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-h...)
Affinity DataIC50:  100nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8504(2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-hydrox...)
Affinity DataIC50:  120nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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