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Found 519 with Last Name = 'cusack' and Initial = 'kp'
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620450((S)-5-((1-(difluoromethyl)-5-methyl-1H-pyrazol-4-y...)
Affinity DataIC50:  1.80nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620443(US11767310, Example 11)
Affinity DataIC50:  2nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620438(US11767310, Example 6)
Affinity DataIC50:  3nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620434(US11767310, Example 2)
Affinity DataIC50:  4nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620440(US11767310, Example 8)
Affinity DataIC50:  6nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620439(US11767310, Example 7)
Affinity DataIC50:  7nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620446(US11767310, Example 14)
Affinity DataIC50:  8nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50323351(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-isobutyl-6,7-d...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human CYP11B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620433(US11767310, Example 1)
Affinity DataIC50:  11nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50323353(1-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo-4,5...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human CYP11B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620444(US11767310, Example 12)
Affinity DataIC50:  13nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620437(US11767310, Example 5)
Affinity DataIC50:  14nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620441(US11767310, Example 9)
Affinity DataIC50:  18nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50155144(4-(3-Phenyl-1H-indol-2-ylmethylene)-5-pyrazin-2-yl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2(KDR) without DTT(dithiothreitol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620436(US11767310, Example 4)
Affinity DataIC50:  30nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620449(US11767310, Example 17)
Affinity DataIC50:  32nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620435(US11767310, Example 3)
Affinity DataIC50:  36nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620442(US11767310, Example 10)
Affinity DataIC50:  43nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50155149(4-(3-Methyl-1H-indol-2-ylmethylene)-5-pyrazin-2-yl...)
Affinity DataIC50:  60nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2(KDR) without DTT(dithiothreitol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50155148((Z)-4-((4-(2-(diethylamino)ethyl)-3,5-dimethyl-1H-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2(KDR) with DTT(dithiothreitol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM620445(US11767310, Example 13)
Affinity DataIC50:  95nMAssay Description:A fluorescent probe containing an Oregon green fluorophore was synthesized from a compound known to bind to RIPK1.The assay was performed in a buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293248(US10106501, Example DE)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293250(US10106501, Example DG)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293251(US10106501, Example DH)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293252(US10106501, Example DI)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293253(US10106501, Example DJ)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293255(US10106501, Example DL)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293257(US10106501, Example DN)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293258(US10106501, Example DO | US10106501, Example DT)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293259(US10106501, Example DP)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293209(US10106501, Example CJ | US10106501, Example DQ)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292883(US10106501, Example DR | US10106501, Example R)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292869(US10106501, Example DS | US10106501, Example J)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293258(US10106501, Example DO | US10106501, Example DT)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292862(US10106501, Example GG)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292863(US10106501, Example GI)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292864(US10106501, Example GK)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292865(US10106501, Example GN)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292869(US10106501, Example DS | US10106501, Example J)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292872(US10106501, Example L)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292883(US10106501, Example DR | US10106501, Example R)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292884(US10106501, Example S)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292886(US10106501, Example U)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292887(US10106501, Example V)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292893(US10106501, Example AA)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292894(US10106501, Example AA-1)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292895(US10106501, Example AA-2)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292896(US10106501, Example AA-3)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM292897(US10106501, Example AA-4)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM293020(US10106501, Example AA-7)
Affinity DataIC50: <100nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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