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Found 1605 with Last Name = 'dax' and Initial = 'sl'
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144258(4-[(8-Benzo[1,3]dioxol-5-ylmethyl-8-aza-bicyclo[3....)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144236(4-[(R)-(S)-8-Aza-bicyclo[3.2.1]oct-(3Z)-ylidene-ph...)
Affinity DataKi:  0.0230nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144229(4-{[(1S,5R)-8-Allyl-8-aza-bicyclo[3.2.1]oct-(3Z)-y...)
Affinity DataKi:  0.0250nMAssay Description:Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144281(CHEMBL63309 | N-Methyl-4-[(8-phenethyl-8-aza-bicyc...)
Affinity DataKi:  0.140nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144284(CHEMBL68412 | N-Ethyl-4-[(3-hydroxy-phenyl)-(8-thi...)
Affinity DataKi:  0.152nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155124(4-{Bromo-[(1S,5R)-8-furan-3-ylmethyl-8-aza-bicyclo...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144275(CHEMBL419621 | N-Ethyl-4-[(3-hydroxy-phenyl)-(8-ph...)
Affinity DataKi:  0.222nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144249(CHEMBL302801 | N,N-Diethyl-4-{[(1S,5R)-8-phenethyl...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144249(CHEMBL302801 | N,N-Diethyl-4-{[(1S,5R)-8-phenethyl...)
Affinity DataKi:  0.240nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM22((4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis[(...)
Affinity DataKi:  0.25nMAssay Description:Compound was evaluated for binding affinity towards HIV-Protease enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144291(CHEMBL67790 | N-Ethyl-4-[(4-hydroxy-phenyl)-(8-thi...)
Affinity DataKi:  0.25nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144276(CHEMBL63651 | N-Ethyl-4-{[(1S,5R)-8-phenethyl-8-az...)
Affinity DataKi:  0.260nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155085(CHEMBL362331 | N,N-Diethyl-4-[(8-phenethyl-8-aza-b...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147083(1-(4-tert-Butyl-benzyl)-3-isoquinolin-5-yl-urea | ...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144234(4-((R)-(S)-8-Aza-bicyclo[3.2.1]oct-3-yl-phenyl-ami...)
Affinity DataKi:  0.300nMAssay Description:Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144246(4-{[(1R,5S)-8-Allyl-8-aza-bicyclo[3.2.1]oct-(3E)-y...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144233(4-[(S)-(R)-8-Aza-bicyclo[3.2.1]oct-(3E)-ylidene-ph...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144240(CHEMBL65151 | N,N-Diethyl-4-{[8-(2-phenoxy-ethyl)-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144282(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-(3-...)
Affinity DataKi:  0.384nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144244(CHEMBL63571 | N,N-Diethyl-4-[phenyl-(8-propyl-8-az...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM23((4R,5S,6S,7R)-4,7-dibenzyl-1-(cyclopropylmethyl)-5...)
Affinity DataKi:  0.410nMAssay Description:Compound was evaluated for binding affinity towards HIV-Protease enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.480nMAssay Description:Inhibition of [3H]RTX binding to human Vanilloid receptor subtype 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144247(4-[((1S,5R)-8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-...)
Affinity DataKi:  0.5nMAssay Description:Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144273(CHEMBL66741 | N-Ethyl-4-[(3-methoxy-phenyl)-(8-thi...)
Affinity DataKi:  0.510nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144235(CHEMBL63750 | N,N-Diethyl-4-{phenyl-[8-(3-phenyl-p...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144245(4-[(8-Aza-bicyclo[3.2.1]oct-3-ylidene)-(4-hydroxy-...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155068(CHEMBL361720 | N-Ethyl-4-[(8-furan-3-ylmethyl-8-az...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144243(CHEMBL67996 | N,N-Diethyl-4-[(3-hydroxy-phenyl)-(8...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144271(CHEMBL67289 | N-Ethyl-4-[(3-methoxy-phenyl)-(8-phe...)
Affinity DataKi:  0.654nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144284(CHEMBL68412 | N-Ethyl-4-[(3-hydroxy-phenyl)-(8-thi...)
Affinity DataKi:  0.664nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50111690(13-benzyl-6-hydroxy-15-isopropenyl-4,17-dimethyl-5...)
Affinity DataKi:  0.710nMAssay Description:Inhibition of [3H]RTX binding to human Vanilloid receptor subtype 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144293(CHEMBL67240 | N-Ethyl-4-{(3-methoxy-phenyl)-[8-(3-...)
Affinity DataKi:  0.720nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50223336(1-(1-(cyclopropylmethyl)-6-fluoro-1,2,3,4-tetrahyd...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155120(4-[(4-Acetylamino-phenyl)-(8-furan-3-ylmethyl-8-az...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147069(1-(4-Chloro-3-trifluoromethyl-benzyl)-3-isoquinoli...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155082(CHEMBL363287 | N-Ethyl-4-[(8-furan-3-ylmethyl-8-az...)
Affinity DataKi:  0.810nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144266(CHEMBL291357 | N-Ethyl-4-[phenyl-(8-pyridin-2-ylme...)
Affinity DataKi:  0.860nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144289(4-[[8-(2-Chloro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-...)
Affinity DataKi:  0.930nMAssay Description:In vitro binding affinity towards opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50223314(1-(1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,2,3,4-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138503(1-[2-(3,4-Dichloro-phenyl)-ethyl]-3-(7-hydroxy-nap...)
Affinity DataKi:  1nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50223313(1-(1-(4-bromobenzyl)-6-methoxy-1,2,3,4-tetrahydron...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50144268(CHEMBL307973 | N-Cyclopropyl-4-[(8-phenethyl-8-aza...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138515(1-(7-Hydroxy-naphthalen-1-yl)-3-(4-trifluoromethyl...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138518(1-(7-Hydroxy-naphthalen-1-yl)-3-(4-trifluoromethox...)
Affinity DataKi:  1nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155069(4-[Cyano-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataKi:  1nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155096(4-[Benzo[1,3]dioxol-5-yl-(8-furan-3-ylmethyl-8-aza...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147080(3-(4-tert-Butyl-phenyl)-N-isoquinolin-5-yl-acrylam...)
Affinity DataKi:  1.20nMAssay Description:Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155119(4-[(3-Acetylamino-phenyl)-(8-furan-3-ylmethyl-8-az...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50155076(CHEMBL186530 | N-Ethyl-4-[(8-furan-3-ylmethyl-8-az...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against mu opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147067(1-[2-(4-tert-Butyl-phenyl)-ethyl]-3-isoquinolin-5-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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