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Found 109 with Last Name = 'demopoulos' and Initial = 'vj'
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21400(CHEMBL192571 | N-[(4-{[(2R)-4-(dimethylamino)-1-(p...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi:  8nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi:  30nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi:  36nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21400(CHEMBL192571 | N-[(4-{[(2R)-4-(dimethylamino)-1-(p...)
Affinity DataKi:  62nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  180nMAssay Description:Binding affinity to MCL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  320nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  480nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50122956(CHEMBL138065 | [2,4-Bis-(4-methoxy-benzoyl)-pyrrol...)
Affinity DataIC50:  2.36nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCathepsin G(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50:  13.7nMAssay Description:Inhibition of cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  70nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50425858(CHEMBL2312338)
Affinity DataIC50:  190nMAssay Description:Inhibition of Fischer-344 rat kidney ALR1 using D,L-glyceraldehyde as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  249nMAssay Description:Inhibition of aldose reductase in rat lensesMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  249nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  250nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  250nMAssay Description:In vitro inhibitory activity of compound against rat lens aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  250nMAssay Description:Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysisMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330615(4-Amino-N-(4-bromo-2-fluorobenzyl)-N-(3,5-difluoro...)
Affinity DataIC50:  323nMAssay Description:Inhibition of Fischer-344 rat kidney AK1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50336704((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)(...)
Affinity DataIC50:  390nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50146186(CHEMBL329563 | [1-(3-Amino-5-fluoro-4-hydroxy-phen...)
Affinity DataIC50:  396nMAssay Description:In vitro inhibitory activity of compound against rat lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330615(4-Amino-N-(4-bromo-2-fluorobenzyl)-N-(3,5-difluoro...)
Affinity DataIC50:  397nMAssay Description:Inhibition of Fischer-344 rat lens ALR2 by least-square analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50336708((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl)(...)
Affinity DataIC50:  400nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50237838((R)-3-(4,5-dihydroxy-2-nitrophenyl)-2-(3-(4,5-dihy...)
Affinity DataIC50:  741nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50336705((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)(...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50336703((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)(...)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50336702(CHEMBL1673033 | [1-(2,4-Difluoro-3-hydroxyphenyl)-...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50237839((R)-3-(4,5-dihydroxy-2-nitrophenyl)-2-(3-(3,4-dihy...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50146187((3-Benzoyl-pyrrol-1-yl)-acetic acid | 2-(3-benzoyl...)
Affinity DataIC50:  1.97E+3nMAssay Description:In vitro inhibitory activity of compound against rat lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50146187((3-Benzoyl-pyrrol-1-yl)-acetic acid | 2-(3-benzoyl...)
Affinity DataIC50:  1.97E+3nMAssay Description:Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50133496((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...)
Affinity DataIC50:  3.91E+3nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50425857(CHEMBL2312339)
Affinity DataIC50:  4.31E+3nMAssay Description:Inhibition of Fischer-344 rat kidney ALR1 using D,L-glyceraldehyde as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50425859(CHEMBL2312337)
Affinity DataIC50:  5.63E+3nMAssay Description:Inhibition of Fischer-344 rat kidney ALR1 using D,L-glyceraldehyde as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330613(CHEMBL1277386 | N-(4-Bromo-2-fluorobenzyl)-N-(3,5-...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of Fischer-344 rat lens ALR2 by least-square analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50308548(4-(3-Benzoyl-1H-pyrrol-1-yl)butanoic acid | CHEMBL...)
Affinity DataIC50:  6.04E+3nMAssay Description:Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330610(CHEMBL1277203 | N-(4-(N-(3,5-Difluoro-4-hydroxyphe...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of Fischer-344 rat kidney AK1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330610(CHEMBL1277203 | N-(4-(N-(3,5-Difluoro-4-hydroxyphe...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of Fischer-344 rat lens ALR2 by least-square analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330614(CHEMBL1277387 | N-(4-Bromo-2-fluorobenzyl)-N-(3,5-...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of Fischer-344 rat lens ALR2 by least-square analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50308547(3-(3-Benzoyl-1H-pyrrol-1-yl)propanoic acid | CHEMB...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330616(CHEMBL1277477 | N-(3,5-Difluoro-4-hydroxyphenyl)-N...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of Fischer-344 rat kidney AK1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50336706((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl)(...)
Affinity DataIC50:  9.93E+3nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50251025(4-Amino-N-(3,5-difluoro-4-hydroxyphenyl)benzenesul...)
Affinity DataIC50:  1.03E+4nMAssay Description:Inhibition of Fischer-344 rat kidney AK1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330613(CHEMBL1277386 | N-(4-Bromo-2-fluorobenzyl)-N-(3,5-...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of Fischer-344 rat kidney AK1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50330611(CHEMBL1277297 | N-(4-(N-(3,5-Difluoro-4-hydroxyphe...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Fischer-344 rat lens ALR2 by least-square analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50001061(CHEMBL3236020)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of Fischer-344 rat kidney ALR1 using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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