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Found 45 with Last Name = 'dod' and Initial = 'jr'
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  8nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  84nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324926((S)-3-(2-Amino-5-chloro-benzoimidazol-1-yl)-pentan...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324903(4-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-cycloh...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324934((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324913(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(c...)
Affinity DataIC50:  5.90E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324915((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324931((R)-methyl 2-((S)-3-(2-amino-5-chloro-1H-benzo[d]i...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324908(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(c...)
Affinity DataIC50:  8.30E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324932((S)-2-((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol...)
Affinity DataIC50:  8.70E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324927((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  9.50E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324930((S)-methyl 2-((S)-3-(2-amino-5-chloro-1H-benzo[d]i...)
Affinity DataIC50:  1.68E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324904(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-is...)
Affinity DataIC50:  1.93E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324912(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(3...)
Affinity DataIC50:  1.94E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324933((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  2.35E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324920((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  2.43E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324917((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  2.46E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324910(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(3...)
Affinity DataIC50:  2.49E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324929((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  2.64E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324921((3S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324909(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(1...)
Affinity DataIC50:  3.25E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324928((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  3.40E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324923((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  3.75E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324907(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(p...)
Affinity DataIC50:  4.26E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324919((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  4.40E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324906(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(2...)
Affinity DataIC50:  4.44E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324914((R)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  5.16E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324918((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50:  6.95E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM31794(2-aminobenzimidazole deriv., 4 | 5-Chloro-1H-benzo...)
Affinity DataIC50:  7.31E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324898(3-(2-amino-5-chloro-1H-benzimidazol-1-yl)propan-1-...)
Affinity DataIC50:  7.70E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324901(2,2-dihydroxy-1H-indene-1,3(2H)-dione | CHEMBL1221...)
Affinity DataIC50:  7.76E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324905(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(2...)
Affinity DataIC50:  8.27E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324899(3-(3-chlorophenyl)imidazo[1,2-a]pyrimidine | CHEMB...)
Affinity DataIC50:  8.62E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324897(1-methoxy-2-phenyl-1H-imidazo[4,5-b]pyridine | CHE...)
Affinity DataIC50:  9.28E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324925((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324924((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324916((R)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324900(3-(pyridin-4-yl)imidazo[1,2-a]pyrimidine | CHEMBL1...)
Affinity DataIC50:  1.01E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324902(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-be...)
Affinity DataIC50:  1.40E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM50324911(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(c...)
Affinity DataIC50:  2.85E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed