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Found 2073 with Last Name = 'dolle' and Initial = 're'
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]-diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50007377(2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2-pyr...)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity for human Kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176375(2-(3,4-dichlorophenylamino)-N-((S)-2-((S)-3-hydrox...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176369(CHEMBL201884 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50155498((S)-3-(3,4-Dichloro-phenyl)-1-[(S)-2-((S)-3-hydrox...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human Kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176370(CHEMBL201572 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50205684(CHEMBL230288 | N1-((S)-2-((S)-3-hydroxypyrrolidin-...)
Affinity DataKi:  0.270nMAssay Description:Agonist activity at human kappa opioid receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176374(CHEMBL382932 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50155494(3-(3,4-Dichloro-phenyl)-1-(1-phenyl-2-pyrrolidin-1...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity for human Kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176373(2-(2-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176365(CHEMBL201905 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50166621(CHEMBL191987 | N-[(S)-2-((S)-3-Hydroxy-pyrrolidin-...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]-diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM86965((S)-5-amino-2-((S)-2-(((3R,4R)-4-(3-hydroxyphenyl)...)
Affinity DataKi:  0.410nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50252953(CHEMBL494479 | N,N-Diethyl-4-(6-hydroxyspiro[chrom...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM50199910(3-((7R,8R,9alphaR)-7,8-dimethyl-2-(2-chlorobenzyl)...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM86964(2-((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4...)
Affinity DataKi:  0.470nMMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176367(2-(3-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM86968((S)-6-amino-2-((S)-2-(((3R,4R)-4-(3-hydroxyphenyl)...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM50136591(3-[(3R,4R)-3,4-Dimethyl-1-(3,5,5-trimethyl-hexyl)-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50297321(CHEMBL551613 | Isoindolin-2-yl(4-(spiro[chromene-2...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50205686(CHEMBL230607 | N1-((S)-2-((S)-3-hydroxypyrrolidin-...)
Affinity DataKi:  0.530nMAssay Description:Agonist activity at human kappa opioid receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM50199896(3-((2R,3R,7S,9-alpha-S)-2,3-dimethyl-7-phenyl-octa...)
Affinity DataKi:  0.570nM ΔG°:  -52.8kJ/mole IC50:  0.530nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50166619(CHEMBL425897 | N-[(S)-2-((S)-3-Hydroxy-pyrrolidin-...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]-diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM50199896(3-((2R,3R,7S,9-alpha-S)-2,3-dimethyl-7-phenyl-octa...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM50199896(3-((2R,3R,7S,9-alpha-S)-2,3-dimethyl-7-phenyl-octa...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM86969((R)-2-((S)-2-(((3R,4R)-4-(3-hydroxyphenyl)-3,4-dim...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176376(2-(4-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataKi:  0.660nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50297339(CHEMBL557458 | N,N-Diethyl-2-hydroxy-4-(spiro[chro...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50155495(1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluor...)
Affinity DataKi:  0.720nMAssay Description:Binding affinity for human Kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50207832(CHEMBL247758 | H-Cdp-ala-Gly-Phe-leu-OH)
Affinity DataKi:  0.780nMAssay Description:Displacement of [3H]diprenorphine from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50176372(CHEMBL201283 | N-((S)-2-((S)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50166613(2-{4-[(Butane-1-sulfonylamino)-methyl]-phenyl}-N-[...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]-diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50174961((R)-N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phen...)
Affinity DataKi:  0.800nMAssay Description:Agonistic activity at kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50213144(CHEMBL233184 | morpholin-4-yl-acetic acid 4-(1,1-d...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]CP55940 from cloned human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50252954(ADL-5859 | CHEMBL494480 | N,N-diethyl-4-(5-hydroxy...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM50199900(3-((1R,2R,7S,9-alpha-S)-1,2-dimethyl-7-phenyl-octa...)
Affinity DataKi:  0.900nMAssay Description:Antagonist activity against human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of loperamide-stimulated [35S]GTP-gamma-S b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50297329((R)-N,N-diethyl-4-(spiro[chroman-2,4'-piperidine]-...)
Affinity DataKi:  0.930nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM50199945(3-((7R,8R,9alphaR)-7,8-dimethyl-2-(2-methylbenzyl)...)
Affinity DataKi:  0.980nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50176362(2-((4-cyanophenyl)(methyl)amino)-N-((S)-2-((S)-3-h...)
Affinity DataKi:  1nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
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Curated by PDSP Ki Database
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCannabinoid receptor 2(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50213141(4-(1,1-dimethyl-heptyl)-2'-methoxy-biphenyl-2-ol |...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]CP55940 from cloned human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058526((S)-3-{[(1S,9S)-9-(4-Carboxymethoxy-benzoylamino)-...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058530((S)-3-{[(1S,9S)-9-(2-Fluoro-benzoylamino)-6,10-dio...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50207833(CHEMBL246572 | H-Aba-ala-Gly-Phe-Met-OH)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]diprenorphine from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50207825(CHEMBL246739 | H-Cdp-Gly-Gly-Phe-Leu-OH)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]diprenorphine from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM50199914(3-((7R,8R,9alphaR)-2-benzyl-7,8-dimethyl-octahydro...)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/mole IC50:  11nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50304919(CHEMBL595268 | N-(3,4-dimethyl-5-(morpholinosulfon...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by PDSP Ki Database
LigandPNGBDBM50199941(3-((7R,8R,9alphaR)-2-(cyclohexylmethyl)-7,8-dimeth...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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