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Found 809 with Last Name = 'dragovic' and Initial = 'j'
TargetBombesin receptor subtype-3(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50336889((2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]Bag-3 from rat BRS-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50336889((2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]Bag-3 from rat BRS-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50336889((2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]Bag-3 from mouse BRS-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336889((2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336886(1-[4-(2,2-dimethylpropyl)-1H-imidazol-2-yl]-2-[4-(...)
Affinity DataKi:  4.20E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336885(2-[4-(2,2-dimethylpropyl)-1H-imidazol-2-yl]-1-[4-(...)
Affinity DataKi:  5.90E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336889((2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]...)
Affinity DataKi: >8.00E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50381918(CHEMBL2023113)
Affinity DataIC50:  0.5nMAssay Description:Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50381917(CHEMBL2023112)
Affinity DataIC50:  0.5nMAssay Description:Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50381916(CHEMBL2023111)
Affinity DataIC50:  0.600nMAssay Description:Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400247(CHEMBL2179918)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394612(CHEMBL2164581)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394616(CHEMBL2164577)
Affinity DataIC50:  0.760nMAssay Description:Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400254(CHEMBL2179911)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394609(CHEMBL2164223)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50377869(CHEMBL402552)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50377880(CHEMBL404436)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50377878(CHEMBL258447)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50377883(CHEMBL256291)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340399(4-methyl-3-(4-((4-(methylsulfonyl)phenoxy)methyl)b...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244238(CHEMBL499372 | trans-4-(((5-(benzyloxy)-1-methyl-1...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50377881(CHEMBL256720)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(CHEMBL500315 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340380(CHEMBL1761310 | N-((4-(4-methyl-5-(2-(trifluoromet...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244265(CHEMBL480113 | trans-4-((4-tert-butylcyclohexyl)(1...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340389(3-(4-((4-chlorophenoxy)methyl)bicyclo[2.2.2]octan-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394613(CHEMBL2164580)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400257(CHEMBL2179908)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340394(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394611(CHEMBL2164582)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340394(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394615(CHEMBL2164578)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50381915(CHEMBL2023110)
Affinity DataIC50:  1.40nMAssay Description:Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174299(2,2,2-trifluoro-1-(4-(5-(4-(4-methyl-5-(2-(trifluo...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340389(3-(4-((4-chlorophenoxy)methyl)bicyclo[2.2.2]octan-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340392(4-methyl-3-(4-(2-(2,2,2-trifluoroethylsulfonyl)eth...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340373(4-methyl-3-(4-(2-(phenylsulfonyl)ethyl)bicyclo[2.2...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174288(3-(4-(5-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl)bic...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340402(3-(4-(4-(ethylsulfonyl)butyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400246(CHEMBL2179473)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340396(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394608(CHEMBL2164224)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBombesin receptor subtype-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394617(CHEMBL2164576)
Affinity DataIC50:  1.72nMAssay Description:Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340402(3-(4-(4-(ethylsulfonyl)butyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174281(4-methyl-3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5-(2...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340376(3-(4-(2-(4-fluorophenylsulfonyl)ethyl)bicyclo[2.2....)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174284(4-methyl-3-(4-(3-(4-(methylsulfonyl)phenyl)-1,2,4-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174298(3-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)bicy...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174295(4-methyl-3-(2-(trifluoromethyl)phenyl)-5-(4-(3-(4-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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