TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 0.0800nMAssay Description:Displacement of [125I]RTI55 binding from human wild type SERTMore data for this Ligand-Target Pair
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 0.840nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 0.850nMAssay Description:Competitive inhibition of human recombinant AKR1C1 Phe311Leu mutant by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.851nMAssay Description:Displacement of [3H]-methylspiperone from human D2 long receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 0.860nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 0.890nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H] raclopride from human recombinant D2L receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]-methylspiperone from human D2 long receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor incubated for 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Displacement of [125I]RTI55 binding from human wild type SERTMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Competitive inhibition of human recombinant AKR1C1 Leu308Ala mutant by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Competitive inhibition of wild-type human recombinant N-terminal His6-tagged AKR1B10 expressed in Escherichia coli using geraniol as substrate by dou...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Competitive inhibition of human recombinant AKR1C1 Phe311Ala mutant by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of human AKR1C2 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Competitive inhibition of human recombinant AKR1C1 Leu308Val mutant by fluorescence assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells after 1 hr by microbeta plate reader analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells after 1 hr by microbeta plate reader analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]-raclopride from human D2R expressed in HEK293 cells after 1 hr by microbeta plate reader analysisMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Competitive inhibition of recombinant human AKR1B10 in presence of geraniol as substrate by Lineweaver-Burk plot methodMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Competitive inhibition at human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as inhibition of NADP+ lin...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Inhibition of dehydrogenase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of geraniol deh...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodMore data for this Ligand-Target Pair
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells after 1 hr by microbeta plate reader analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 3.5nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells after 1 hr by microbeta plate reader analysisMore data for this Ligand-Target Pair
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 3.70nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of human recombinant 20-alpha HSD expressed in Escherichia coli JM109More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor incubated for 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting me...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 4.10nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair
TargetCoagulation factor XII(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 4.5nMAssay Description:Inhibition of human beta factor 12a using fluorogenic substrate Boc-Gln-Gly-Arg-AMC preincubated for 10 mins followed by addition of substrate measur...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 4.80nMAssay Description:Competitive inhibition of human recombinant AKR1C1 Leu54Val mutant by fluorescence assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Displacement of [3H]citalopram from human SERT in HEK293 cells by Topcount scintillation analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting me...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells after 1 hr by microbeta plate reader analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cells incubated for 1 hr by liquid scintillation counter methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor expressed in CHOK1 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Polish Academy Of Sciences
Curated by ChEMBL
Polish Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cells incubated for 1 hr by liquid scintillation counter methodMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 5.90nM ΔG°: -47.0kJ/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 5.90nMAssay Description:Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assayMore data for this Ligand-Target Pair