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Found 105 with Last Name = 'fauchère' and Initial = 'jl'
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50452012(CHEMBL2110187)
Affinity DataIC50:  1nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50092365((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139576(4-(5-{[2-(2-Methyl-benzyl)-3-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50404819(CHEMBL33000)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory activity contractions of electrically stimulated mouse vas deferens was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50404816(CHEMBL434006)
Affinity DataIC50:  3.90nMAssay Description:Inhibitory activity contractions of electrically stimulated mouse vas deferens was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139567(4-(5-{[2-(3-Chloro-phenyl)-3-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  4nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045033(1N-[1-[1-benzyl(methyl)carbamoyl-2-phenyl-(1S)-eth...)
Affinity DataIC50:  6nMAssay Description:Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139588(4-(5-{[2-(3-Methoxy-phenyl)-3-oxo-2,3,4,5-tetrahyd...)
Affinity DataIC50:  6nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139580(4-(5-{[2-(3-Chloro-benzyl)-3-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139568(4-{5-[((S)-1-Benzyl-2-oxo-azepan-3-ylamino)-methyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139570(4-(5-{[2-(3,5-Difluoro-benzyl)-3-oxo-2,3,4,5-tetra...)
Affinity DataIC50:  8nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139591(4-(5-{[2-(3-Fluoro-phenyl)-3-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  9nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50452137(CHEMBL2372195)
Affinity DataIC50:  9.80nMAssay Description:Inhibitory activity contractions of electrically stimulated mouse vas deferens was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139585(4-(5-{[2-(3,5-Difluoro-phenyl)-3-oxo-2,3,4,5-tetra...)
Affinity DataIC50:  10nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139592(4-(5-{[2-(2-Chloro-benzyl)-3-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139579(4-(5-{[2-(3-Nitro-phenyl)-3-oxo-2,3,4,5-tetrahydro...)
Affinity DataIC50:  13nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139582(4-(5-{[2-(3,5-Dichloro-phenyl)-3-oxo-2,3,4,5-tetra...)
Affinity DataIC50:  15nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139583(4-(5-{[2-(3-Bromo-phenyl)-3-oxo-2,3,4,5-tetrahydro...)
Affinity DataIC50:  15nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139575(4-{5-[(2-Benzyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataIC50:  17nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045040(CHEMBL3144343 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  17nMAssay Description:Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139590(4-(5-{[3-Oxo-2-(2,3,5-trifluoro-benzyl)-2,3,4,5-te...)
Affinity DataIC50:  18nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139573(4-(5-{[3-(3-Chloro-phenyl)-2-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  19nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50452011(CHEMBL2110188)
Affinity DataIC50:  19nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50404817(CHEMBL431895)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity contractions of electrically stimulated mouse vas deferens was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045036(7-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  21nMAssay Description:Tested for binding affinity against human NK-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139569(4-(5-{[3-(3-Bromo-benzyl)-2-oxo-2,3,4,5-tetrahydro...)
Affinity DataIC50:  22nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139578(4-(5-{[3-(2-Chloro-benzyl)-2-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  23nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139577(4-(5-{[3-(3-Chloro-benzyl)-2-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  23nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139574(4-{5-[(3-Oxo-2-phenyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataIC50:  26nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139586(4-(5-{[3-(3,5-Difluoro-benzyl)-2-oxo-2,3,4,5-tetra...)
Affinity DataIC50:  26nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Sanofi Recherche

Curated by ChEMBL
LigandPNGBDBM50025903(4-(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-pr...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Sanofi Recherche

Curated by ChEMBL
LigandPNGBDBM50024167(3-Hydroxy-4-[2-(3-hydroxy-6-methyl-4-{2-[2-(3-meth...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Sanofi Recherche

Curated by ChEMBL
LigandPNGBDBM50024187(4-(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-pr...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139571(4-(5-{[3-(3,5-Dichloro-phenyl)-2-oxo-2,3,4,5-tetra...)
Affinity DataIC50:  32nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50404815(CHEMBL218872)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity contractions of electrically stimulated mouse vas deferens was determinedMore data for this Ligand-Target Pair
Ligand InfoCHEMBLPC sid
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045039(6-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  34nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Sanofi Recherche

Curated by ChEMBL
LigandPNGBDBM50421779(CHEMBL308300 | CHEMBL3142338)
Affinity DataIC50:  37nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Sanofi Recherche

Curated by ChEMBL
LigandPNGBDBM50421775(CHEMBL3142326 | CHEMBL73556)
Affinity DataIC50:  42nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045036(7-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  45nMAssay Description:Tested for binding affinity against human NK-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045039(6-(3-{2-[1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethy...)
Affinity DataIC50:  46nMAssay Description:Tested for binding affinity against human NK-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139572(4-{5-[(2-Cyclohexylmethyl-3-oxo-2,3,4,5-tetrahydro...)
Affinity DataIC50:  47nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50404820(CHEMBL431501)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity contractions of electrically stimulated mouse vas deferens was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Sanofi Recherche

Curated by ChEMBL
LigandPNGBDBM50226299(CHEMBL3142798)
Affinity DataIC50:  51nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139587(4-{5-[(2-Oxo-3-phenyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataIC50:  54nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045040(CHEMBL3144343 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  54nMAssay Description:Tested for antagonist activityt against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139566(4-(5-{[3-(2-Methyl-benzyl)-2-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  54nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139584(4-(5-{[2-(2,4-Difluoro-benzyl)-3-oxo-2,3,4,5-tetra...)
Affinity DataIC50:  55nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50139589(4-(5-{[3-(3,5-Difluoro-phenyl)-2-oxo-2,3,4,5-tetra...)
Affinity DataIC50:  62nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045037(CHEMBL3144352 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  65nMAssay Description:Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Rattus norvegicus (Rat))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50045037(CHEMBL3144352 | N-Benzyl-2-[2-[2-(3,6-dioxo-2,5-di...)
Affinity DataIC50:  65nMAssay Description:Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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