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Found 9 with Last Name = 'freund' and Initial = 'y'
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50:  730nMAssay Description:Inhibition of human recombinant PDE7A1 expressed in baculovirus-infected insect Sf9 cells by modified two-step methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant PDE7A1 expressed in baculovirus-infected insect Sf9 cells by modified two-step methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of human recombinant PDE1A3 expressed in baculovirus-infected insect Sf9 cells by modified two-step methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50059035(3-Isobutyl-8-methoxymethyl-1-methyl-3,7-dihydro-pu...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant PDE1A3 expressed in baculovirus-infected insect Sf9 cells by modified two-step methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in pooled human liver microsomes using dextromethorphan as substrate preincubated for 30 mins in presence of NADPH followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens)
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in pooled human liver microsomes using (S)-(+)-mephenytoin as substrate preincubated for 30 mins in presence of NADPH followed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in pooled human liver microsomes using diclofenac as substrate preincubated for 30 mins in presence of NADPH followed by substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in pooled human liver microsomes using midazolam or testosterone as substrate preincubated for 30 mins in presence of NADPH foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in pooled human liver microsomes using phenacetin as substrate preincubated for 30 mins in presence of NADPH followed by substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed