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Found 257 with Last Name = 'golec' and Initial = 'jm'
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
TargetAurora kinase C(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nM ΔG°:  -47.1kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  6nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341751(3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfon...)
Affinity DataKi:  6nMAssay Description:Competitive inhibition of full length recombinant ATR Morrison equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283345((S)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydrox...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290014((S)-2-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydrox...)
Affinity DataKi:  9nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283348((S)-3-{(S)-2-[(S)-2-(3,3-Dichloro-propionylamino)-...)
Affinity DataKi:  28nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetAromatase(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283341((S)-3-{(S)-2-[(S)-2-((S)-2-Acetylamino-3-phenyl-pr...)
Affinity DataKi:  42nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290009((S)-3-(2-{3-[2-Acetylamino-2-(4-hydroxy-phenyl)-ac...)
Affinity DataKi:  54nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290012((S)-2-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylam...)
Affinity DataKi:  54nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50058529((S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  55nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283346((S)-3-[(S)-2-({(S)-2-[(S)-2-Acetylamino-3-(4-hydro...)
Affinity DataKi:  59nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  80nM ΔG°:  -40.1kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283338((S)-3-((S)-2-{(S)-2-[(S)-2-(Acetyl-methyl-amino)-3...)
Affinity DataKi:  120nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290015((S)-4-Oxo-3-{(S)-2-[2-oxo-3-(3-phenyl-propionylami...)
Affinity DataKi:  150nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290006((S)-3-{2-[6-Benzyl-2-oxo-3-(3-phenyl-propionylamin...)
Affinity DataKi:  150nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  350nM ΔG°:  -36.5kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283343(3-((S)-2-{(S)-2-[(S)-2-((S)-Acetylamino)-3-(4-hydr...)
Affinity DataKi:  500nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290011((S)-4-Oxo-3-{2-[2-oxo-6-phenyl-3-(3-phenyl-propion...)
Affinity DataKi:  900nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290005((S)-3-{2-[6-Benzyl-2-oxo-3-(3-phenyl-propionylamin...)
Affinity DataKi:  970nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290007((S)-3-{2-[6-Butyl-2-oxo-3-(3-phenyl-propionylamino...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290013((S)-4-Oxo-3-{2-[2-oxo-6-phenethyl-3-(3-phenyl-prop...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290016((S)-2-[2-((S)-2-Benzyloxycarbonylamino-3-methyl-bu...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283350((S)-3-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylam...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283349((S)-3-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-pheny...)
Affinity DataKi:  2.10E+3nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283342((S)-3-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-pheny...)
Affinity DataKi:  2.40E+3nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290008((S)-3-{2-[6-Methyl-2-oxo-3-(3-phenyl-propionylamin...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290010((S)-4-Oxo-3-{2-[2-oxo-3-(3-phenyl-propionylamino)-...)
Affinity DataKi:  4.80E+3nMAssay Description:Inhibition of IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283347((S)-3-((S)-2-Acetylamino-propionylamino)-4-oxo-but...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091562(3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-ph...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283344((S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-prop...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283340((S)-3-[((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydro...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283339((S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-prop...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283352((S)-3-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-prop...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283351((S)-3-[(S)-2-((S)-2-{[(S)-2-Acetylamino-3-(4-hydro...)
Affinity DataKi:  5.00E+4nMAssay Description:Binding affinity towards IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161329(US10087143, Compound 114 | US10738009, Compound 11...)
Affinity DataIC50:  1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161329(US10087143, Compound 114 | US10738009, Compound 11...)
Affinity DataIC50:  1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161326(US10087143, Compound 111 | US10738009, Compound 11...)
Affinity DataIC50:  3nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161326(US10087143, Compound 111 | US10738009, Compound 11...)
Affinity DataIC50:  3nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM186571(US10787472, Compound 1 | US9163042, 1)
Affinity DataIC50:  4nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM186571(US10787472, Compound 1 | US9163042, 1)
Affinity DataIC50:  4nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161328(US10087143, Compound 113 | US10738009, Compound 11...)
Affinity DataIC50:  6nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341750(3-amino-6-(4-(tert-butylsulfonyl)phenyl)-N-phenylp...)
Affinity DataIC50:  6nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161328(US10087143, Compound 113 | US10738009, Compound 11...)
Affinity DataIC50:  6nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341747(3-amino-6-(4-(isopropylsulfonyl)phenyl)-N-phenylpy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341752(3-amino-6-(4-((4-hydroxybutan-2-yl)sulfonyl)phenyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341749(3-amino-6-(4-(sec-butylsulfonyl)phenyl)-N-phenylpy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341753((R)-3-amino-N-phenyl-6-(4-((tetrahydrofuran-3-yl)s...)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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