Compile Data Set for Download or QSAR
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Found 102 with Last Name = 'handscombe' and Initial = 'c'
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065508((R)-4-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-4...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065516((R)-4-[2-Cyano-5-(pyridin-3-ylmethoxy)-phenoxy]-4-...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085853(CHEMBL173251 | Sodium; [2-cyano-5-(pyridin-4-ylmet...)
Affinity DataIC50:  5nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085859((2-Chloro-phenyl)-[2-cyano-5-(pyridin-4-ylmethoxy)...)
Affinity DataIC50:  6nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085845(CHEMBL174235 | [5-(Benzooxazol-6-ylmethoxy)-2-cyan...)
Affinity DataIC50:  6nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085833(CHEMBL172144 | Sodium; [5-(benzo[1,3]dioxol-5-ylme...)
Affinity DataIC50:  7nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065524(5-[2-(3-Carboxy-1-o-tolyl-propoxy)-4-(thiophen-3-y...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065523((R)-4-[2-Cyano-5-(isothiazol-4-ylmethoxy)-phenoxy]...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065518(4-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-4-o-t...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065518(4-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-4-o-t...)
Affinity DataIC50:  8nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085861(CHEMBL170681 | [5-(Benzooxazol-6-ylmethoxy)-2-cyan...)
Affinity DataIC50:  9nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085831(CHEMBL174092 | [2-Cyano-5-(pyridin-4-ylmethoxy)-ph...)
Affinity DataIC50:  9nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085830(CHEMBL173792 | [5-(Benzo[1,3]dioxol-5-ylmethoxy)-2...)
Affinity DataIC50:  12nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50329850((R)-3-Amino-4-[(S)-2-((R)-1-{(S)-1-[(R)-1-(1H-indo...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085838(CHEMBL352536 | [5-(Benzo[1,3]dioxol-5-ylmethoxy)-2...)
Affinity DataIC50:  14nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085855(CHEMBL170202 | [5-(Benzo[1,3]dioxol-5-ylmethoxy)-2...)
Affinity DataIC50:  16nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085840((2-Chloro-phenyl)-[2-cyano-5-(thiophen-3-ylmethoxy...)
Affinity DataIC50:  17nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085835(CHEMBL427294 | [2-Cyano-5-(thiophen-3-ylmethoxy)-p...)
Affinity DataIC50:  20nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065525(4-[2-(1H-Pyrazol-3-yl)-5-(thiophen-3-ylmethoxy)-ph...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065515((R)-4-[2-Cyano-5-(pyridin-4-ylmethoxy)-phenoxy]-4-...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065513(4-[2-Oxazol-2-yl-5-(thiophen-3-ylmethoxy)-phenoxy]...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085854(CHEMBL171638 | [2-Cyano-5-(thiophen-3-ylmethoxy)-p...)
Affinity DataIC50:  22nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085832(CHEMBL171513 | [2-Cyano-5-(2-fluoro-pyridin-4-ylme...)
Affinity DataIC50:  23nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065521(4-[2-Acetyl-5-(thiophen-3-ylmethoxy)-phenoxy]-4-o-...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065512(4-[2-Carbamoyl-5-(thiophen-3-ylmethoxy)-phenoxy]-4...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085864(CHEMBL354740 | [2-Cyano-5-(thiazol-5-ylmethoxy)-ph...)
Affinity DataIC50:  30nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085839(CHEMBL170348 | [2-Cyano-5-(pyridin-3-ylmethoxy)-ph...)
Affinity DataIC50:  30nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065520(4-[2-Pyridin-2-yl-5-(thiophen-3-ylmethoxy)-phenoxy...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085856(CHEMBL355413 | [5-(Benzo[1,3]dioxol-5-ylmethoxy)-2...)
Affinity DataIC50:  41nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085858((2-Chloro-phenyl)-[2-cyano-5-(pyridazin-4-ylmethox...)
Affinity DataIC50:  44nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085860((5-Benzyloxy-2-cyano-phenoxy)-o-tolyl-acetic acid ...)
Affinity DataIC50:  49nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085844((2-Bromo-phenyl)-[2-cyano-5-(thiophen-3-ylmethoxy)...)
Affinity DataIC50:  51nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085837(CHEMBL170715 | [2-Cyano-5-(thiophen-3-ylmethoxy)-p...)
Affinity DataIC50:  53nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085836(CHEMBL172412 | [2-Cyano-5-(furan-3-ylmethoxy)-phen...)
Affinity DataIC50:  68nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065522((R)-4-[5-(Benzo[1,3]dioxol-5-ylmethoxy)-2-cyano-ph...)
Affinity DataIC50:  69nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085852(CHEMBL174229 | [2-Cyano-5-(thiophen-3-ylmethoxy)-p...)
Affinity DataIC50:  70nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085843(CHEMBL173444 | [5-(Benzooxazol-5-ylmethoxy)-2-cyan...)
Affinity DataIC50:  75nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065539((E)-3-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenyl]-2-...)
Affinity DataIC50:  80nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085863((3-Chloro-phenyl)-[2-cyano-5-(thiophen-3-ylmethoxy...)
Affinity DataIC50:  98nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065514(5-Oxo-5-[3-(thiophen-3-ylmethoxy)-phenyl]-4-o-toly...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065511((S)-4-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-4...)
Affinity DataIC50:  113nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065533((E)-3-[2-Cyano-5-(pyridin-3-ylmethoxy)-phenyl]-2-p...)
Affinity DataIC50:  150nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065545((E)-2-Benzo[1,3]dioxol-5-yl-3-[2-cyano-5-(thiophen...)
Affinity DataIC50:  200nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065548((E)-2-(2-Chloro-phenyl)-3-[2-cyano-5-(thiophen-3-y...)
Affinity DataIC50:  200nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065510(2-(3-Carboxy-1-o-tolyl-propoxy)-4-(thiophen-3-ylme...)
Affinity DataIC50:  207nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085862(CHEMBL366788 | [2-Cyano-5-(isothiazol-3-ylmethoxy)...)
Affinity DataIC50:  220nMAssay Description:In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065543(2-((E)-3-Hydroxy-2-o-tolyl-propenyl)-4-(thiophen-3...)
Affinity DataIC50:  300nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065544((E)-3-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenyl]-2-...)
Affinity DataIC50:  300nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065537((E)-2-(2-Chloro-phenyl)-3-[2-nitro-5-(thiophen-3-y...)
Affinity DataIC50:  400nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50065528((E)-3-[2-Nitro-5-(thiophen-3-ylmethoxy)-phenyl]-2-...)
Affinity DataIC50:  500nMAssay Description:Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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