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Found 185 with Last Name = 'harbeson' and Initial = 'sl'
TargetAminopeptidase B(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017480(5-Amino-8-guanidino-2-(4-hydroxy-benzyl)-4-oxo-oct...)
Affinity DataKi:  0.840nMAssay Description:Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017482(5-Amino-2-benzyl-8-guanidino-4-oxo-octanoic acid |...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017486(2-(2-{4-Hydroxy-2,7-dimethyl-5-[3-methyl-2-(3-meth...)
Affinity DataKi:  3nMAssay Description:Inhibition of enzyme pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017485(1N-[1-isopentylcarbamoyl-(1S)-ethyl]-4-[1-(1-amino...)
Affinity DataKi:  3nMAssay Description:Inhibition of enzyme pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017476(5,9-Diamino-2-benzyl-4-oxo-nonanoic acid | CHEMBL2...)
Affinity DataKi:  4nMAssay Description:Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKi:  14nMAssay Description:Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKi:  20nMAssay Description:Inhibition of leucine aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017478(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  20nMAssay Description:Inhibition of aminopeptidase M or membrane leucine aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143464(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039998(CHEMBL99129 | [(S)-1-((S)-1-Ethylcarbamoyl-butylca...)
Affinity DataKi:  32nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  35nMAssay Description:Tested for inhibitory activity on human calpain 2 from placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040007(CHEMBL316932 | [(S)-1-((S)-1-Ethylcarbamoyl-2-phen...)
Affinity DataKi:  36nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Bos taurus)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  40nMAssay Description:Tested for inhibitory activity on bovine calpain 2 from heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  42nMAssay Description:Tested for inhibitory activity on porcine calpain 2 from kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Bos taurus)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  50nMAssay Description:Tested for inhibitory activity on bovine calpain 2 from heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  51nMAssay Description:Tested for inhibitory activity on porcine calpain 2 from kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040009(CHEMBL101791 | {(S)-1-[(S)-1-((S)-1-Ethylcarbamoyl...)
Affinity DataKi:  61nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  66nMAssay Description:Tested for inhibitory activity on human calpain 1 from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  73nMAssay Description:Tested for inhibitory activity on human calpain 2 from placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  74nMAssay Description:Tested for inhibitory activity on human calpain 1 from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  78nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039994(CHEMBL419898 | [(S)-1-(1-Ethylcarbamoyl-butylcarba...)
Affinity DataKi:  78nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  89nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039995(CHEMBL98777 | [(S)-1-(1-Ethylcarbamoyl-2-phenyl-et...)
Affinity DataKi:  89nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143458((4S,5R)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039999((S)-2-[(R)-3-((S)-2-Benzyloxycarbonylamino-4-methy...)
Affinity DataKi:  92nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040000(CHEMBL327974 | {(R)-1-[(S)-1-((S)-1-Ethylcarbamoyl...)
Affinity DataKi:  93nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50027141(1-(5-Benzoylamino-4-oxo-6-phenyl-hexanoyl)-pyrroli...)
Affinity DataKi:  100nMAssay Description:Compound was evaluated for the inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143472((4S,5R)-3-sec-Butyl-1-((R)-2-{2-cyclohexyl-2-[(hyd...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143459((4S,5R)-3-Cyclohexyl-1-((R)-2-{2-cyclohexyl-2-[(hy...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039993(CHEMBL330186 | [(S)-1-(3-Ethylcarbamoyl-propylcarb...)
Affinity DataKi:  109nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039993(CHEMBL330186 | [(S)-1-(3-Ethylcarbamoyl-propylcarb...)
Affinity DataKi:  109nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017481(2-(2-{2,7-Dimethyl-5-[3-methyl-2-(3-methyl-butyryl...)
Affinity DataKi:  110nMAssay Description:Inhibition of enzyme pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135430(CHEMBL434033 | Naphthalene-2-carboxylic acid (3R,5...)
Affinity DataKi:  110nMAssay Description:Inhibition of HCV (Hepatitis C Virus) NS3-4A protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040001((S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-meth...)
Affinity DataKi:  116nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039996(CHEMBL98950 | Morpholine-4-carboxylic acid [(S)-1-...)
Affinity DataKi:  119nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143470(2-((S)-3-{[(4S,5R)-3-sec-Butyl-1-((R)-3-methyl-2-{...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039993(CHEMBL330186 | [(S)-1-(3-Ethylcarbamoyl-propylcarb...)
Affinity DataKi:  122nMAssay Description:Tested for inhibitory activity on bovine calpain 2 from heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040004(CHEMBL330417 | {(S)-1-[(R)-1-Benzyl-2-(2-ethanesul...)
Affinity DataKi:  129nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Bos taurus)
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039993(CHEMBL330186 | [(S)-1-(3-Ethylcarbamoyl-propylcarb...)
Affinity DataKi:  138nMAssay Description:Tested for inhibitory activity on bovine calpain II from heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-2 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50039993(CHEMBL330186 | [(S)-1-(3-Ethylcarbamoyl-propylcarb...)
Affinity DataKi:  138nMAssay Description:Tested for inhibitory activity on human calpain II from placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143469((4S,5S)-1-((R)-2-{2-Cyclohexyl-2-[(hydroxy-pyrazin...)
Affinity DataKi:  150nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50008434(5-Amino-2-benzyl-7-methyl-4-oxo-octanoic acid | CH...)
Affinity DataKi:  170nMAssay Description:Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Alkermes

Curated by ChEMBL
LigandPNGBDBM50040008(CHEMBL100395 | [(S)-1-(3-Ethylcarbamoyl-propylcarb...)
Affinity DataKi:  170nMAssay Description:In vitro inhibition of porcine erythrocyte calpain 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143471((4S,5S)-2-[1-((S)-(S)-1-Carboxy-2-phenyl-ethylamin...)
Affinity DataKi:  180nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141206(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141198(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.15)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141210(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.15)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141194(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.03)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141196(1-[3-methyl-2-[2-methyl-1-(2-pyrazinylcarboxamido)...)
Affinity DataKi: <200nMAssay Description:Binding inhibition of hepatitis C virus NS3.4A protease 2 using p-nitroaniline assay (pNA); <0.2 (0.18)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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