TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human phosphodiesterase 4 from U937 cellsMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience
Curated by ChEMBL
Celltech-Chiroscience
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience
Curated by ChEMBL
Celltech-Chiroscience
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of rolipram binding to PDE4 of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience
Curated by ChEMBL
Celltech-Chiroscience
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D
Curated by ChEMBL
Celltech R&D
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories
Curated by ChEMBL
Charles River Laboratories
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC5 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC7 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC9 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Class 2A HDAC4 in human Jurkat E6.1 cells using Boc-Lys-(TFA)-AMC as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Class 2A HDAC4 in human Jurkat E6.1 cells using Boc-Lys-(TFA)-AMC as substrate by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair