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Found 500 with Last Name = 'hermes' and Initial = 'jd'
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301603((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301604((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301619((S)-3-((S)-1-(4-(5-(2-aminopyrimidin-4-yl)-1H-benz...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301624((S)-4-methyl-N(S)-4-methyl-N-(naphthalen-1-yl)-3-(...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301605((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301607((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301594(3-(1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-ylam...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301594(3-(1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-ylam...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301588((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301618((S)-3-((S)-1-(4-(5-(3-ethyl-2-oxoimidazolidin-1-yl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301608(CHEMBL566507 | ethyl 2-((S)-2-((S)-1-(4-(1H-benzo[...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98812(US8487093, 204)
Affinity DataIC50:  0.800nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98802(US8487093, 192)
Affinity DataIC50:  0.800nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301587(CHEMBL567885 | rac 3-(1-(4-(1H-benzo[d]imidazol-1-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301617((S)-1-ethyl-3-(1-(2-(1-phenylethylamino)pyrimidin-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301621((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetH2-K region expressed gene 2, rat orthologue(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079829(((S)-1-{(S)-1-[(S)-1-((S)-1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  1nMAssay Description:Ability to inhibit binding of biotinylated rat myelin basic protein 13-mer peptide (RMBP 90-102, Major histocompatibility complex class II to purifie...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetH2-K region expressed gene 2, rat orthologue(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079824(((S)-1-{(S)-1-[(S)-(S)-1-(1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  1nMAssay Description:Ability to inhibit binding of biotinylated rat myelin basic protein 13-mer peptide (RMBP 90-102, Major histocompatibility complex class II to purifie...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98861(US8487093, 7)
Affinity DataIC50:  1.10nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98792(US8487093, 180)
Affinity DataIC50:  1.20nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50079824(((S)-1-{(S)-1-[(S)-(S)-1-(1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289286(((R)-1-{(S)-1-[(S)-1-((S)-1-Carbamoyl-3-methyl-but...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II MHC for ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301616((S)-4-(5-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidaz...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98862(US8487093, 8)
Affinity DataIC50:  1.60nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98862(US8487093, 8)
Affinity DataIC50:  1.60nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98819(US8487093, 212)
Affinity DataIC50:  1.80nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301606((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98847(US8487093, 266)
Affinity DataIC50:  2nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98806(US8487093, 196)
Affinity DataIC50:  2nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98799(US8487093, 188)
Affinity DataIC50:  2nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301595(3-(1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-ylam...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301623((S)-N-(1-phenylethyl)-4-(5-(pyridin-4-yl)-1H-benzo...)
Affinity DataIC50:  3nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98834(US8487093, 242)
Affinity DataIC50:  3nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98800(US8487093, 190)
Affinity DataIC50:  3nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98798(US8487093, 186)
Affinity DataIC50:  3nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98790(US8487093, 176)
Affinity DataIC50:  3nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98831(US8487093, 236)
Affinity DataIC50:  4nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98810(US8487093, 200)
Affinity DataIC50:  4nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98833(US8487093, 240)
Affinity DataIC50:  4nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
Merck

Curated by ChEMBL
LigandPNGBDBM50347189(CHEMBL1795572)
Affinity DataIC50:  5nMAssay Description:Inhibition of Pseudomonas aeruginosa beta lactamase AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98808(US8487093, 198)
Affinity DataIC50:  5nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289247((S)-2-((S)-3-Carbamoyl-2-{(S)-2-[((R)-2-ethoxycarb...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98811(US8487093, 202)
Affinity DataIC50:  6nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98854(US8487093, 17)
Affinity DataIC50:  6nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98822(US8487093, 218)
Affinity DataIC50:  6nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98860(US8487093, 6)
Affinity DataIC50:  6nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMHC class II antigen(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289278((S)-2-[(S)-3-Carbamoyl-2-((S)-2-{[(R)-2-ethoxycarb...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory concentration required to inhibit the binding of biotinylated rat myelin basic protein peptide (RMBP90-102) against DR1 allele of class II...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98788(US8487093, 172)
Affinity DataIC50:  7nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM98789(US8487093, 174)
Affinity DataIC50:  7nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
Merck

Curated by ChEMBL
LigandPNGBDBM50347184(CHEMBL1795567)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of Pseudomonas aeruginosa beta lactamase AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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