Compile Data Set for Download or QSAR
maximum 50k data
Found 3441 with Last Name = 'hewitt' and Initial = 'mc'
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337818(CHEMBL1683876 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334773(CHEMBL1642904 | trans-((2R,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337831(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337830(CHEMBL1683875 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334781(CHEMBL1642912 | Cis-2-((2S,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337829(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337830(CHEMBL1683875 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50337831(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337831(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50337913((+/-)-N,N-dimethyl-1-(1-(naphthalen-2-yl)cyclohexy...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433673(US10562878, Compound 254 | US10562878, Compound 26...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433711(US10562878, Compound 268 | US10562878, Compound 26...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433734(US10562878, Compound 206 E1 | US10562878, Compound...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337915((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-3-methy...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337844(1-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-4-met...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433654(US10562878, Compound 115)
Affinity DataIC50: <1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337829(1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dimethylm...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM433905(US10562878, Compound 161 E1 | US10562878, Compound...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337823(1-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)pyrrol...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433675(US10562878, Compound 72)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337832(CHEMBL1683873 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337822(4-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)morpho...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM433842(US10562878, Compound 63 E1 | US10562878, Compound ...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337823(1-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)pyrrol...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337832(CHEMBL1683873 | N-((1-(3,4-dichlorophenyl)cyclohex...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334787(CHEMBL1642902 | cis-((2S,4S)-4-(3,4-dichlorophenyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337822(4-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)morpho...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50:  2nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM433736(US10562878, Compound 147 E1 | US10562878, Compound...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337910((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...)
Affinity DataIC50:  2.20nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Affinity DataIC50:  2.30nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433673(US10562878, Compound 254 | US10562878, Compound 26...)
Affinity DataIC50:  2.40nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433764(US10562878, Compound 273 | US10562878, Compound 27...)
Affinity DataIC50:  2.70nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)
Affinity DataIC50:  2.90nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337831(CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...)
Affinity DataIC50:  2.90nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334770(CHEMBL1642900 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRDT BD1 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRDT BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50337833(CHEMBL1683902 | N,N-dimethyl-1-(1-(naphthalen-2-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337833(CHEMBL1683902 | N,N-dimethyl-1-(1-(naphthalen-2-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433835(US10562878, Compound 233 | US10562878, Compound 23...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50:  3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM433652(US10562878, Compound 116)
Affinity DataIC50:  3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Displayed 1 to 50 (of 3441 total ) | Next | Last >>
Jump to: