Affinity DataIC50: 120nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA S83W mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA S83W mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA S83W mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 2.32E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 3.13E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 3.15E+4nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 3.48E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 3.59E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School
Curated by ChEMBL
University Of Minnesota Medical School
Curated by ChEMBL
Affinity DataIC50: 3.65E+4nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.37E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 4.41E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 5.77E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 5.83E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 5.86E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA after 15 to 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair