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Found 95 with Last Name = 'hiasa' and Initial = 'h'
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50272019(CHEMBL4127152)
Affinity DataIC50:  120nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483022(8-Methoxy Fluoroquinolone | CHEMBL1276635)
Affinity DataIC50:  120nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50272016(CHEMBL4130153)
Affinity DataIC50:  120nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50205450((S)-7-(3-(aminomethyl)pyrrolidin-1-yl)-1-cycloprop...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50272016(CHEMBL4130153)
Affinity DataIC50:  120nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  440nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543559(CHEMBL4648309)
Affinity DataIC50:  950nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483022(8-Methoxy Fluoroquinolone | CHEMBL1276635)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483022(8-Methoxy Fluoroquinolone | CHEMBL1276635)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483021(CHEMBL1276667)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483022(8-Methoxy Fluoroquinolone | CHEMBL1276635)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA S83W mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483021(CHEMBL1276667)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483021(CHEMBL1276667)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483020(CHEMBL1276666)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483020(CHEMBL1276666)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543557(CHEMBL4636070)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483021(CHEMBL1276667)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA S83W mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483020(CHEMBL1276666)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483020(CHEMBL1276666)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA S83W mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50551686(CHEMBL4751047)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543560(CHEMBL4644781)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50272017(CHEMBL4130314)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512182(CHEMBL4454117)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543563(CHEMBL4645741)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483023(CHEMBL1276697)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50272010(CHEMBL4126896)
Affinity DataIC50:  2.32E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase subunit GyrA/GyrB supercoiling activity using relaxed pBR322 DNA incubated for 15 mins by ethidium bromide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512207(CHEMBL4471194)
Affinity DataIC50:  2.59E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512206(CHEMBL4558064)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A(Escherichia coli (strain K12))
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483023(CHEMBL1276697)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA G81C mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512215(CHEMBL4550067)
Affinity DataIC50:  3.13E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  3.15E+4nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512210(CHEMBL4541775)
Affinity DataIC50:  3.33E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512187(CHEMBL4449682)
Affinity DataIC50:  3.48E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512192(CHEMBL4466968)
Affinity DataIC50:  3.59E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Minnesota Medical School

Curated by ChEMBL
LigandPNGBDBM50483023(CHEMBL1276697)
Affinity DataIC50:  3.65E+4nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512209(CHEMBL4461990)
Affinity DataIC50:  4.37E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50551685(CHEMBL4741215)
Affinity DataIC50:  4.41E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543562(CHEMBL4636102)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543561(CHEMBL4642955)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543564(CHEMBL4644915)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543566(CHEMBL4639662)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543565(CHEMBL4638646)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50543558(CHEMBL4649758)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiling activity by fluorescence assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512217(CHEMBL4452830)
Affinity DataIC50:  5.77E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512181(CHEMBL4441534)
Affinity DataIC50:  5.83E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50512201(CHEMBL4583424)
Affinity DataIC50:  5.86E+4nMAssay Description:Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50395674(CHEMBL1235969)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA after 15 to 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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