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Found 841 with Last Name = 'hornby' and Initial = 'g'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150101(CHEMBL419240 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191633((3S)-3-{(cyclopropylmethyl)[3-(5-fluoro-1H-indol-3...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295066((2S)-8-Methyl-2-{[4-(6-nitroquinolin-2-yl)piperazi...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150096(CHEMBL330827 | [2-(1H-Benzoimidazol-4-yloxy)-ethyl...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150103(CHEMBL338520 | [2-(6-Chloro-1H-benzoimidazol-4-ylo...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191625(CHEMBL208605 | rac-3-{ethyl[4-(5-fluoro-1H-indol-3...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]paroxetine from 5-HT transporter in Sprague-Dawley rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150105(CHEMBL124069 | [2-(6-Fluoro-chroman-8-yloxy)-ethyl...)
Affinity DataKi:  0.470nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150082(CHEMBL126484 | [3-(5-Fluoro-1H-indol-3-yl)-propyl]...)
Affinity DataKi:  0.480nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150099(CHEMBL339490 | [2-(7-Fluoro-2,3-dihydro-benzo[1,4]...)
Affinity DataKi:  0.490nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150107(CHEMBL340705 | [3-(1H-Indol-3-yl)-propyl]-[2-(quin...)
Affinity DataKi:  0.540nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274186((+)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)propyl...)
Affinity DataKi:  0.660nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150096(CHEMBL330827 | [2-(1H-Benzoimidazol-4-yloxy)-ethyl...)
Affinity DataKi:  0.690nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150101(CHEMBL419240 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306472(6-fluoro-3-(1-(2-(7-methoxybenzofuran-3-yl)ethyl)-...)
Affinity DataKi:  0.760nMAssay Description:Displacement of [3H]paroxetine from 5-HT transporter in rat frontal cortical synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274782(8-Fluoro-3-{[3-(5-fluoro-1H-indol-3-yl)propyl](pro...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150092(CHEMBL331609 | [2-(1H-Benzoimidazol-4-yloxy)-ethyl...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295064((2S)-2-{[4-(6-Chloroquinolin-2-yl)piperazin-1-yl]m...)
Affinity DataKi:  0.880nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.900nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274784(3-{[3-(5-Fluoro-1H-indol-3-yl)propyl](propyl)amino...)
Affinity DataKi:  0.930nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.960nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50166904(CHEMBL193206 | N-{(R)-2-[4-(2,3-Dihydro-benzo[1,4]...)
Affinity DataKi:  1nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50160612(CHEMBL362823 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataKi:  1.05nMAssay Description:Binding affinity determined against Serotonin transporter determined bydisplacement of [3H]-paroxetine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50160611(CHEMBL359549 | [4-(5-Fluoro-1H-indol-3-yl)-cyclohe...)
Affinity DataKi:  1.08nMAssay Description:Binding affinity determined against human 5-hydroxytryptamine 1A receptors transfected into CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150081(CHEMBL126536 | [3-(5-Fluoro-1H-indol-3-yl)-propyl]...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295055(2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50252278(3-[(1,4-cis)-4-(4-Quinoxalin-5-yl-piperazin-1-yl)-...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]paroxetine from rat cortical 5HTT reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150097(CHEMBL339810 | [2-(5-Fluoro-2,3-dihydro-benzofuran...)
Affinity DataKi:  1.17nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274487(3-{Cyclobutyl[3-(5-methoxy-1H-indol-3-yl)propyl]am...)
Affinity DataKi:  1.19nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150090(CHEMBL125902 | [3-(5-Fluoro-1H-indol-3-yl)-propyl]...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209674(CHEMBL391531 | N-(3-(5-fluoro-1H-indol-3-yl)propyl...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake site of rat cortical 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50166901(4-Chloro-N-{(R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin...)
Affinity DataKi:  1.20nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306469(6-fluoro-3-(1-(2-(6-methoxybenzofuran-3-yl)ethyl)-...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]paroxetine from 5-HT transporter in rat frontal cortical synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191615((3R)-(-)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)p...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191615((3R)-(-)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)p...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209674(CHEMBL391531 | N-(3-(5-fluoro-1H-indol-3-yl)propyl...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake site of rat cortical 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50252221(3-[(1,4-cis)-4-(4-Quinolin-8-yl-piperazin-1-yl)-cy...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]paroxetine from rat cortical 5HTT reuptake siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209679(CHEMBL234853 | N-(3-(5-fluoro-1H-indol-3-yl)propyl...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake site of rat cortical 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150082(CHEMBL126484 | [3-(5-Fluoro-1H-indol-3-yl)-propyl]...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274224((3R)-(-)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)p...)
Affinity DataKi:  1.32nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306480(3-(1-(2-(benzofuran-3-yl)ethyl)-1,2,3,6-tetrahydro...)
Affinity DataKi:  1.33nMAssay Description:Displacement of [3H]paroxetine from 5-HT transporter in rat frontal cortical synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150086(CHEMBL127171 | [3-(5-Fluoro-1H-indol-3-yl)-propyl]...)
Affinity DataKi:  1.36nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295054((2S)-2-{[4-(6-Fluoroquinolin-2-yl)-1,4-diazepan-1-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50209682(CHEMBL233624 | N-(4-(5-fluoro-1H-indol-3-yl)butyl)...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake site of rat cortical 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191615((3R)-(-)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)p...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191619((3R)-(-)-8-Fluoro-3-{[3-(5-fluoro-1H-indol-3-yl)pr...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150085(CHEMBL126424 | [3-(5-Fluoro-1H-indol-3-yl)-propyl]...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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