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Found 253 with Last Name = 'howie' and Initial = 'kj'
TargetD(2) dopamine receptor(Homo sapiens (Human))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.125nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007400(4-Phenyl-1-(4-phenyl-butyl)-piperidine | 4-Phenyl-...)
Affinity DataKi:  0.800nMAssay Description:The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007396(4-Phenyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL11...)
Affinity DataKi:  0.900nMAssay Description:The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Affinity DataKi:  0.940nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007393(4-Phenyl-1-(3-phenyl-propyl)-piperidine | CHEMBL11...)
Affinity DataKi:  1.10nMAssay Description:The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007401(1-Phenyl-4-(4-phenyl-butyl)-piperazine | CHEMBL858...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007409(1-Naphthalen-2-yl-4-(3-phenyl-propyl)-piperazine |...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007410(1-(4-Chloro-phenyl)-4-(3-phenyl-propyl)-piperazine...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007398(4-Phenyl-1-(3-phenyl-propyl)-piperidin-4-ol | 4-ph...)
Affinity DataKi:  3nMAssay Description:The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006981(CHEMBL19841 | [1-Methyl-2-(3-trifluoromethyl-pheny...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007397(1-(3-Naphthalen-2-yl-propyl)-4-phenyl-piperazine |...)
Affinity DataKi:  4nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007395(4-(4-Chloro-phenyl)-1-(4-phenyl-butyl)-1,2,3,6-tet...)
Affinity DataKi:  4.10nMAssay Description:The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007399(1-(4-Phenyl-butyl)-4-(3-trifluoromethyl-phenyl)-pi...)
Affinity DataKi:  5.40nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5.80nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006982(CHEMBL281619 | [2-(3-Bromo-phenyl)-1-methyl-ethyl]...)
Affinity DataKi:  6nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006974(CHEMBL53253 | [1-Methyl-2-(4-propyl-phenyl)-ethyl]...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006972((1-Methyl-2-naphthalen-2-yl-ethyl)-(3-phenyl-propy...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007392(1-Phenyl-4-(3-phenyl-propyl)-piperazine | CHEMBL11...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006969(CHEMBL20768 | [2-(4-Ethoxy-phenyl)-1-methyl-ethyl]...)
Affinity DataKi:  6.80nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007405(1-Phenethyl-4-(3-trifluoromethyl-phenyl)-piperazin...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006968((3-Phenyl-propyl)-(6,7,8,9-tetrahydro-5H-benzocycl...)
Affinity DataKi:  7.90nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006970(CHEMBL293952 | [2-(4-Iodo-phenyl)-1-methyl-ethyl]-...)
Affinity DataKi:  8.30nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006975(CHEMBL19802 | [2-(4-Bromo-phenyl)-1-methyl-ethyl]-...)
Affinity DataKi:  8.80nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006967(CHEMBL53170 | [2-(4-Methoxy-phenyl)-1-methyl-ethyl...)
Affinity DataKi:  9.5nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006978(4-[2-(3-Phenyl-propylamino)-propyl]-phenol | CHEMB...)
Affinity DataKi:  10nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  10nMAssay Description:The compound was tested for its binding affinity towards Sigma opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007404(1-(3-Chloro-phenyl)-4-phenethyl-piperazine | CHEMB...)
Affinity DataKi:  11nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006973(CHEMBL298758 | [2-(3,4-Dichloro-phenyl)-1-methyl-e...)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006971((1-Methyl-2-naphthalen-1-yl-ethyl)-(3-phenyl-propy...)
Affinity DataKi:  18nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007412(1-(3-Chloro-phenyl)-4-(3-phenyl-propyl)-piperazine...)
Affinity DataKi:  19nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006980((3-Phenyl-propyl)-(1,2,3,4-tetrahydro-naphthalen-2...)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041279(((R)-1-Methyl-2-phenyl-ethyl)-(3-phenyl-propyl)-am...)
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041261(((S)-1-Methyl-2-phenyl-ethyl)-(3-phenyl-propyl)-am...)
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006977(CHEMBL55317 | Indan-2-yl-(3-phenyl-propyl)-amine)
Affinity DataKi:  27nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006976(CHEMBL54808 | [2-(4-Benzyloxy-phenyl)-1-methyl-eth...)
Affinity DataKi:  27nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM81982(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Affinity DataKi:  29nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007402(1-Phenyl-4-propyl-piperazine | 1-Phenyl-4-propylpi...)
Affinity DataKi:  74nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM81924((R)-3-(1-Propyl-piperidin-3-yl)-phenol | 3PPP(+/-)...)
Affinity DataKi:  79nMAssay Description:Opioid activity in terms of inhibition of [3H]dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50006979((3-Phenyl-propyl)-(6,7,8,9-tetrahydro-5H-benzocycl...)
Affinity DataKi:  83nMAssay Description:Inhibition of [3H]DTG binding to Sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007413(CHEMBL19351 | Phenyl-[4-(4-phenyl-butyl)-piperazin...)
Affinity DataKi:  125nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM11638(CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl...)
Affinity DataKi:  160nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM11638(CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl...)
Affinity DataKi:  205nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Oregon Health Sciences University

Curated by PDSP Ki Database
LigandPNGBDBM11638(CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl...)
Affinity DataKi:  206nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

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