Compile Data Set for Download or QSAR
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Found 468 with Last Name = 'hu' and Initial = 'sx'
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  2.04nMAssay Description:Inhibition of Abl by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  4.19nMAssay Description:Inhibition of Lyn by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  5.97nMAssay Description:Inhibition of Yes by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  7.22nMAssay Description:Inhibition of Src by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  7.27nMAssay Description:Inhibition of EphB4 by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  11.7nMAssay Description:Inhibition of Lck by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  12.9nMAssay Description:Inhibition of Yes by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  19.4nMAssay Description:Inhibition of Abl by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  25.9nMAssay Description:Inhibition of Lyn by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  28.1nMAssay Description:Inhibition of Src by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  29.4nMAssay Description:Inhibition of Lck by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  63.8nMAssay Description:Inhibition of EphB4 by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110617(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-[3-[(S)-2-(2-b...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110623(1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[3-{(S)-2-[2-(1...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110626(1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[3-{(S)-2-[2-(1...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110618(1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethy...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090552(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090540(7-Chloro-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-3-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110618(1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethy...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110599(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimeth...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110619(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimeth...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]-inositol phosphate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496759(CHEMBL3222130)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090555(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  0.400nMAssay Description:Compound was evaluated for its inhibitory activity against rat pituitary Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110627(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimeth...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50327846(1-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(t...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110611(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-[3-{(S)-2-[2-(...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110627(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimeth...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]-inositol phosphate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110600(5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]-inositol phosphate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110613(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimeth...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110597(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-[3-[(S)-2-(2-b...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  0.440nMAssay Description:In vitro inhibition of binding of the compound to GnRH receptor in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090542(7-Chloro-3-(4-iodo-3-methyl-phenyl)-2-oxo-4-((S)-2...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496748(CHEMBL3222118)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of gonadotropin-releasing hormone receptor in rhesus monkeyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496754(CHEMBL3222131)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110614(1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[3-[(S)-2-(2-be...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110620(1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethy...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110594(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-(2-(3,5-dimeth...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]-inositol phosphate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110593(5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110595(1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-[3-[(S)-2-(2-be...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50496753(CHEMBL3222129)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090555(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  0.600nMAssay Description:Compound was evaluated for its antagonism in rat primary pituitary cell assay (rLH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110593(5-(2-{(S)-2-[5-[2-(2-Aza-bicyclo[2.2.2]oct-2-yl)-1...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110606(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-[3-{(S)-2-[2-(...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]-inositol phosphate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110596(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimeth...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]-inositol phosphate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090588(7-Chloro-3-(3,4-dimethyl-phenyl)-2-oxo-4-((S)-2-pi...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090576(7-Chloro-3-indan-5-yl-2-oxo-4-((S)-2-piperidin-2-y...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110607(1-(2-Aza-bicyclo[2.2.2]oct-2-yl)-2-(2-(3,5-dimethy...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110592(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimeth...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of [125I]-buserelin binding to human pituitary gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50104543(1-(7-Aza-bicyclo[2.2.1]hept-7-yl)-2-{2-(3,5-dimeth...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]-inositol phosphate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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