Affinity DataKi: 0.0230nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 0.0330nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 0.0640nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 0.0870nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 0.300nMAssay Description:In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 0.320nMAssay Description:In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...More data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 0.340nMAssay Description:In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 0.410nMAssay Description:In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 0.480nMAssay Description:In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...More data for this Ligand-Target Pair
Affinity DataKi: 0.550nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 0.75nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 2.37nMAssay Description:In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...More data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -48.2kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 3.10nMAssay Description:In vitro binding affinity at 5-HT1A receptor by measuring its ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocam...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 6.5nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 6.90nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 7.20nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 7.20nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 11.9nMAssay Description:In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -44.8kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 12.2nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 12.8nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nM ΔG°: -44.6kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 13nM ΔG°: -44.6kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 14nM ΔG°: -44.4kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Preclinical R & D, Astra Arcus
Curated by PDSP Ki Database
Affinity DataKi: 14nMAssay Description:In vitro binding affinity at 5-HT1A receptors assayed by displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampal membr...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 17.3nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair