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Found 189 with Last Name = 'kihara' and Initial = 't'
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081804((Difluoro-{(1R,2S)-2-[2-(6-oxo-1,6-dihydro-purin-9...)
Affinity DataKi:  8.80nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081803(CHEMBL94840 | {1,1-Difluoro-2-[(3R,4R)-4-(6-oxo-1,...)
Affinity DataKi:  15nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081807(({(1R,2S)-2-[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-...)
Affinity DataKi:  28nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataKi:  53nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312905(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312902(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50014113(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312892(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  14nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312903(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  16nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312904(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  22nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081803(CHEMBL94840 | {1,1-Difluoro-2-[(3R,4R)-4-(6-oxo-1,...)
Affinity DataIC50:  35nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081806(CHEMBL94920 | {1,1-Difluoro-2-[(3R,4S)-4-(6-oxo-1,...)
Affinity DataIC50:  37nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  40nMAssay Description:Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  40nMAssay Description:Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081804((Difluoro-{(1R,2S)-2-[2-(6-oxo-1,6-dihydro-purin-9...)
Affinity DataIC50:  70nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312897(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  79nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312887(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  83nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081803(CHEMBL94840 | {1,1-Difluoro-2-[(3R,4R)-4-(6-oxo-1,...)
Affinity DataIC50:  88nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312890(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  97nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312891(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  100nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312815((3aS,8aR)-3a,8-dimethyl-1-(2-(pyridin-2-yl)ethyl)-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312817((3aS,8aR)-3a,8-dimethyl-1-(2-(pyridin-4-yl)ethyl)-...)
Affinity DataIC50:  170nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50014113(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  170nMAssay Description:Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312818((3aS,8aR)-3a,8-dimethyl-1-(2-(piperidin-1-yl)ethyl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312902(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  180nMAssay Description:Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312816((3aS,8aR)-3a,8-dimethyl-1-(2-(pyridin-3-yl)ethyl)-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM10960((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  240nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  280nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  280nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081806(CHEMBL94920 | {1,1-Difluoro-2-[(3R,4S)-4-(6-oxo-1,...)
Affinity DataIC50:  320nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081807(({(1R,2S)-2-[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-...)
Affinity DataIC50:  330nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Tokyo Institute Of Technology

US Patent
LigandPNGBDBM149319(US8962674, CU532)
Affinity DataIC50:  330nMpH: 4.5 T: 2°CAssay Description:Compounds were dissolved in dimethylsulfoxide (DMSO), and further diluted in 0.1 M sodium acetate buffer (with 150 mM sodium chloride, pH 4.5). The s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312893(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  340nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081804((Difluoro-{(1R,2S)-2-[2-(6-oxo-1,6-dihydro-purin-9...)
Affinity DataIC50:  340nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312899(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  370nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Tokyo Institute Of Technology

US Patent
LigandPNGBDBM149318(US8962674, CU531)
Affinity DataIC50:  370nMpH: 4.5 T: 2°CAssay Description:Compounds were dissolved in dimethylsulfoxide (DMSO), and further diluted in 0.1 M sodium acetate buffer (with 150 mM sodium chloride, pH 4.5). The s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataIC50:  380nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081807(({(1R,2S)-2-[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-...)
Affinity DataIC50:  390nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312894(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  430nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312903(3alpha,8-dimethyl-1-phenethyl-1,2,3,3alpha,8,8alph...)
Affinity DataIC50:  450nMAssay Description:Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Tokyo Institute Of Technology

US Patent
LigandPNGBDBM149280(US8962674, CU358)
Affinity DataIC50:  480nMpH: 4.5 T: 2°CAssay Description:Compounds were dissolved in dimethylsulfoxide (DMSO), and further diluted in 0.1 M sodium acetate buffer (with 150 mM sodium chloride, pH 4.5). The s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Tokyo Institute Of Technology

US Patent
LigandPNGBDBM149314(US8962674, CU527)
Affinity DataIC50:  480nMpH: 4.5 T: 2°CAssay Description:Compounds were dissolved in dimethylsulfoxide (DMSO), and further diluted in 0.1 M sodium acetate buffer (with 150 mM sodium chloride, pH 4.5). The s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Tokyo Institute Of Technology

US Patent
LigandPNGBDBM149315(US8962674, CU528)
Affinity DataIC50:  490nMpH: 4.5 T: 2°CAssay Description:Compounds were dissolved in dimethylsulfoxide (DMSO), and further diluted in 0.1 M sodium acetate buffer (with 150 mM sodium chloride, pH 4.5). The s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312807((3aS,8aR)-1-(4-fluorophenethyl)-3a,8-dimethyl-1,2,...)
Affinity DataIC50:  500nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312808((3aS,8aR)-1-(4-chlorophenethyl)-3a,8-dimethyl-1,2,...)
Affinity DataIC50:  500nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312804((3aS,8aR)-3a,8-dimethyl-1-(3-phenylpropyl)-1,2,3,3...)
Affinity DataIC50:  510nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312802((3aS,8aR)-1-benzyl-3a,8-dimethyl-1,2,3,3a,8,8a-hex...)
Affinity DataIC50:  510nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Tokyo Institute Of Technology

US Patent
LigandPNGBDBM149301(US8962674, CU473)
Affinity DataIC50:  510nMpH: 4.5 T: 2°CAssay Description:Compounds were dissolved in dimethylsulfoxide (DMSO), and further diluted in 0.1 M sodium acetate buffer (with 150 mM sodium chloride, pH 4.5). The s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312803((3aS,8aR)-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-...)
Affinity DataIC50:  540nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312803((3aS,8aR)-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-...)
Affinity DataIC50:  540nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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