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Found 139 with Last Name = 'kourounakis' and Initial = 'a'
TargetAdenosine receptor A3(Rattus norvegicus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for rat adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]AB-MECA from membranes of HEK 293 cells expressing human Adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  11nMAssay Description:Ability to displace radioligand [125I]AB-MECA from membrane of HEK 293 cells stably transfected with human adenosine A3 receptor cDNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  14nMAssay Description:Binding affinity for human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM35804((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Affinity DataKi:  15nMAssay Description:Ability to displace radioligand [3H]- CGS 21680 from adenosine A2A receptor on rat striatal membraneMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  16nMAssay Description:Ability to displace radioligand [3H]- CGS 21680 from adenosine A2A receptor on rat striatal membraneMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM35804((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Affinity DataKi:  27nMAssay Description:Binding affinity for human adenosine A2A receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  54nMAssay Description:Ability to displace radioligand [3H]- DPCPX from adenosine A1 receptor on rat cortical membrane in the absence of GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  56nMAssay Description:Ability to displace radioligand [3H]- CGS 21680 from adenosine A2A receptor on rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  63nMAssay Description:Ability to displace radioligand [3H]- DPCPX from adenosine A1 receptor on rat cortical membrane in the absence of GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM35804((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Affinity DataKi:  67nMAssay Description:Displacement of [125I]AB-MECA from membranes of HEK 293 cells expressing human Adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  113nMAssay Description:Binding affinity for rat adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50369495(CHEMBL606095)
Affinity DataKi:  160nMAssay Description:Ability to displace radioligand [3H]- CGS 21680 from adenosine A2A receptor on rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50369495(CHEMBL606095)
Affinity DataKi:  211nMAssay Description:Ability to displace radioligand [125I]AB-MECA from membrane of HEK 293 cells stably transfected with human adenosine A3 receptor cDNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50369495(CHEMBL606095)
Affinity DataKi:  257nMAssay Description:Ability to displace radioligand [3H]- DPCPX from adenosine A1 receptor on rat cortical membrane in the absence of GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM35804((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Affinity DataKi:  289nMAssay Description:Binding affinity for human adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  530nMAssay Description:Ability to displace radioligand [3H]- DPCPX from adenosine A1 receptor on rat cortical membrane in the presence of 1 mM of GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM35804((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Affinity DataKi:  584nMAssay Description:Binding affinity for rat adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50369495(CHEMBL606095)
Affinity DataKi:  804nMAssay Description:Ability to displace radioligand [3H]- DPCPX from adenosine A1 receptor on rat cortical membrane in the presence of 1 mM of GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  2.52E+3nMAssay Description:Binding affinity for human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden University

Curated by ChEMBL
LigandPNGBDBM35804((CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmet...)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [3H]- DPCPX from adenosine A1 receptor on rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50503912(CHEMBL4581613)
Affinity DataIC50:  14nMAssay Description:Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene preincubated for 10 mins followed by [3H]FPP additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50118897((1-{2-[1-(3-Acetoxy-2,2-dimethyl-propyl)-7-chloro-...)
Affinity DataIC50:  78nMAssay Description:Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene after 45 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50503918(CHEMBL4465470)
Affinity DataIC50:  160nMAssay Description:Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene preincubated for 10 mins followed by [3H]FPP additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50431176(CHEMBL2332556)
Affinity DataIC50:  210nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as inhibition of [3H] FPP conversion to squalene after 10 mins by scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50431176(CHEMBL2332556)
Affinity DataIC50:  210nMAssay Description:Inhibition of SQS in rat microsomes using [3H]-FPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50503920(CHEMBL4470186)
Affinity DataIC50:  510nMAssay Description:Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene preincubated for 10 mins followed by [3H]FPP additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50125785(CHEMBL3623842)
Affinity DataIC50:  700nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50329674(2-[4-(2-Naphthalen)-phenyl]-4-methyl-octahydro-1,4...)
Affinity DataIC50:  800nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as [3H] FPP to squalene conversion level after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50253937(2-[4-(2-Bromo-5-thienyl)phenyl]-4-methyl-octahydro...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotelian University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of soybean lipoxygenase after 7 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50329672(2-[4-(6-Methoxy-2-naphthalen)-phenyl]-4-methyl-oct...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as [3H] FPP to squalene conversion level after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50007813(CHEMBL3234111)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50329673(2-[4-(2-Naphthalen)-phenyl]-4-methylmorpholin-2-ol...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as [3H] FPP to squalene conversion level after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50253939(2-[4-(2-Benzothiazolyl)phenyl]-4-methylmorpholin-2...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50007809(CHEMBL3234107)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50007806(CHEMBL3234104)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50503911(CHEMBL4541664)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene preincubated for 10 mins followed by [3H]FPP additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50253493(3-[4-(4-Bromophenyl)phenyl]-octahydro-1,4-pyrido[2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50007814(CHEMBL3234112)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50007815(CHEMBL3234113)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50007808(CHEMBL3234106)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50253492(2-[4-(4-Bromophenyl)phenyl]-4-methyl-octahydro-1,4...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50007810(CHEMBL3234108)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50357699(CHEMBL1915486)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of rat microsomal squalene synthase activity assessed as conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50007805(CHEMBL3234103)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50253314(2-[4-(2-Benzothiazolyl)phenyl]-octahydro-1,4-pyrid...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50253901(2-[4-(2-Thienyl)phenyl]-4-methylmorpholin-2-ol | C...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50125784(CHEMBL3623843)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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