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Found 685 with Last Name = 'kwiatkowski' and Initial = 'n'
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  21nM ΔG°:  -43.4kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM22450(N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  48nM ΔG°:  -41.4kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM22450(N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4...)
Affinity DataKi:  88nM ΔG°:  -39.9kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataKi:  142nM ΔG°:  -38.7kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataKi:  995nM ΔG°:  -33.9kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  2.00E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM22450(N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4...)
Affinity DataKi:  6.10E+3nM ΔG°:  -29.5kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Notre Dame

LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataKi:  6.30E+3nM ΔG°:  -29.4kJ/molepH: 7.4 T: 2°CAssay Description:To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50539902(CHEMBL4644893)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86616(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  2.60nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataIC50:  3nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86614(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  3.20nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)
Affinity DataIC50:  3.20nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50539903(CHEMBL4641226)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM50337135(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  3.40nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86615(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  3.70nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86613(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  5.10nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  5.60nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  5.60nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86601(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 7)
Affinity DataIC50:  5.90nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86602(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 8)
Affinity DataIC50:  6.10nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86598(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 3)
Affinity DataIC50:  7.20nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  8nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 19(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50353060(CHEMBL4167193)
Affinity DataIC50:  8nMAssay Description:Inhibition of human CDK19 (M1 to N360 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM50337135(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  8.40nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86599(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 4)
Affinity DataIC50:  8.80nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86606(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  9nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataIC50:  9.10nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM519553(US11142507, Compound MFH-4-70-1)
Affinity DataIC50:  9.86nMAssay Description:Jurkat cells were treated with DMSO or concentration of compound indicated. 6 hours after treatment, cells were washed and harvested by resuspending ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86610(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  10.7nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-dependent kinase 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50539902(CHEMBL4644893)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA1 expressed in baculovirus infected Sf9 insect cells using FRET-labeled...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-dependent kinase 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50539903(CHEMBL4641226)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA1 expressed in baculovirus infected Sf9 insect cells using FRET-labeled...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50:  11.3nMAssay Description:In vitro kinase assays with immunoprecipitated proteins (or recombinant CAK complexes) were performed as follows. Kinase reactions were performed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86622(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  11.6nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86611(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  11.9nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM519554(US11142507, Compound MFH-4-73-1)
Affinity DataIC50:  11.9nMAssay Description:Jurkat cells were treated with DMSO or concentration of compound indicated. 6 hours after treatment, cells were washed and harvested by resuspending ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86623(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  13.4nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50526794(CHEMBL4303287 | US10787436, Compound I-18)
Affinity DataIC50:  13.9nMAssay Description:In vitro kinase assays with immunoprecipitated proteins (or recombinant CAK complexes) were performed as follows. Kinase reactions were performed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50573506(CHEMBL4861833)
Affinity DataIC50:  14nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86614(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  14.3nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86615(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  14.5nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86609(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  14.9nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50352632(CHEMBL4167143)
Affinity DataIC50:  15nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50539909(CHEMBL4644643)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM519536(US11142507, Compound MFH-3-110-1)
Affinity DataIC50:  15.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM86601(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 7)
Affinity DataIC50:  15.2nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM50241089(2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoeth...)
Affinity DataIC50:  15.5nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50539906(CHEMBL4648005 | US11142507, Compound MFH-3-35-1)
Affinity DataIC50:  15.7nMAssay Description:Jurkat cells were treated with DMSO or concentration of compound indicated. 6 hours after treatment, cells were washed and harvested by resuspending ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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