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Found 262 with Last Name = 'laplante' and Initial = 's'
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50070797(CHEMBL2370476 | Hexapeptide analogue)
Affinity DataKi:  600nMAssay Description:The apparent Ki value against NS3-4Apep proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50366517(CHEMBL1790303)
Affinity DataKi:  1.40E+4nMAssay Description:The apparent Ki value against NS3-4Apep proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  8.5nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type 2 in transfected SW-13 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193054(3-cyclohexyl-2-(furan-3-yl)-1-methyl-1H-indole-6-c...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193050(3-cyclopentyl-2-(furan-3-yl)-1-methyl-1H-indole-6-...)
Affinity DataIC50:  21nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193059(3-cyclopentyl-2-(furan-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50:  25nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50011004(CHEMBL3259893)
Affinity DataIC50:  28nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162092(3-Cyclohexyl-1-methyl-2-phenyl-1H-indole-6-carboxy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193060(3-cyclohexyl-2-(furan-3-yl)-1H-indole-6-carboxylic...)
Affinity DataIC50:  30nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50011132(ALLINI-1 | CHEMBL3259891)
Affinity DataIC50:  40nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193057(1-cyclohexyl-2-(furan-3-yl)-3-methyl-1H-indole-5-c...)
Affinity DataIC50:  44nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50162094(3-Cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid ...)
Affinity DataIC50:  50nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193069(3-cyclohexyl-2-(furan-3-yl)-1-methyl-1H-pyrrolo[2,...)
Affinity DataIC50:  51nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193063(3-cyclopentyl-2-(furan-3-yl)-7-hydroxy-1-methyl-1H...)
Affinity DataIC50:  75nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50011131(CHEMBL3259890)
Affinity DataIC50:  77nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193055(3-cyclopentyl-2-(furan-3-yl)benzo[b]thiophene-6-ca...)
Affinity DataIC50:  78nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193052(3-cyclohexyl-1-methyl-2-phenyl-1H-pyrrolo[2,3-b]py...)
Affinity DataIC50:  80nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193064(3-cyclopentyl-2-(furan-3-yl)benzofuran-6-carboxyli...)
Affinity DataIC50:  81nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM91713(Androst-4-en-3,17-dione, 2 | Androst-4-ene-3,17-di...)
Affinity DataIC50:  84nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type 2 in transfected SW-13 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193062(3-cyclohexyl-1-methyl-2-(pyridin-2-yl)-1H-indole-6...)
Affinity DataIC50:  90nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370756(CHEMBL1789968)
Affinity DataIC50:  150nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034508((10R,13S,17S)-4-Hydroxy-10,13-dimethyl-3-oxo-2,3,6...)
Affinity DataIC50:  172nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type 2 in transfected SW-13 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193053(1-cyclohexyl-3-methyl-2-phenyl-1H-indole-5-carboxy...)
Affinity DataIC50:  180nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034511((10R,13S,17S)-4-Chloro-10,13-dimethyl-3-oxo-2,3,6,...)
Affinity DataIC50:  192nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type 2 in transfected SW-13 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  218nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type I in transfected 293 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193067(3-cyclohexyl-2-(pyridin-2-yl)-1H-indole-6-carboxyl...)
Affinity DataIC50:  230nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50011044(CHEMBL3259887)
Affinity DataIC50:  270nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193051(7-chloro-3-cyclopentyl-2-(furan-3-yl)-1-methyl-1H-...)
Affinity DataIC50:  290nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50398047(CHEMBL2181641)
Affinity DataIC50:  300nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50011130(CHEMBL3259889)
Affinity DataIC50:  310nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193066(3-cyclopentyl-2-(furan-3-yl)-7-methoxy-1-methyl-1H...)
Affinity DataIC50:  340nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50011043(CHEMBL3259886)
Affinity DataIC50:  350nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034509((10R,13S,17S)-4-Bromo-10,13-dimethyl-3-oxo-2,3,6,7...)
Affinity DataIC50:  387nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type 2 in transfected SW-13 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50398051(CHEMBL2181777)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034507((10R,13S,17S)-4-Mercapto-10,13-dimethyl-3-oxo-2,3,...)
Affinity DataIC50:  437nMAssay Description:In vitro inhibition of human Steroid 5-alpha-reductase type 2 in transfected SW-13 cells using [3H]- delta4-Androstenedione as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50158528((S)-1-cyclohexyl-2-(furan-3-yl)-N-(2-(5-hydroxy-1H...)
Affinity DataIC50:  440nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193058(3-cyclopentyl-2-(furan-3-yl)-7-(methoxycarbonyl)-1...)
Affinity DataIC50:  480nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  600nMAssay Description:Inhibition of DNMT1 (unknown origin) using biotinylated substrate using [3H]-SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034507((10R,13S,17S)-4-Mercapto-10,13-dimethyl-3-oxo-2,3,...)
Affinity DataIC50:  709nMAssay Description:In vitro inhibition of human tSteroid 5-alpha-reductase type I in transfected 293 cells using [3H]- delta4-Androstenedione as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50398049(CHEMBL2181635)
Affinity DataIC50:  800nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193049(1-cyclohexyl-3-methyl-2-(pyridin-2-yl)-1H-indole-5...)
Affinity DataIC50:  820nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50398045(CHEMBL2181618)
Affinity DataIC50:  900nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034509((10R,13S,17S)-4-Bromo-10,13-dimethyl-3-oxo-2,3,6,7...)
Affinity DataIC50:  981nMAssay Description:In vitro inhibition of human tSteroid 5-alpha-reductase type I in transfected 293 cells using [3H]- delta4-Androstenedione as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50398050(CHEMBL2181634)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034511((10R,13S,17S)-4-Chloro-10,13-dimethyl-3-oxo-2,3,6,...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro inhibition of human tSteroid 5-alpha-reductase type I in transfected 293 cells using [3H]- delta4-Androstenedione as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034508((10R,13S,17S)-4-Hydroxy-10,13-dimethyl-3-oxo-2,3,6...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro inhibition of human tSteroid 5-alpha-reductase type I in transfected 293 cells using [3H]- delta4-Androstenedione as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50137488(1-Cyclohexyl-2-furan-3-yl-1H-benzoimidazole-5-carb...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by SPAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50072317(CHEMBL3408841)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 3-like(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM11979(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of DNMT3A/3L (unknown origin) using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50398055(CHEMBL2181789)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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