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Found 91 with Last Name = 'lam' and Initial = 'js'
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50007422((+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50007422((+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50010698((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223503(CHEMBL35556)
Affinity DataIC50:  24nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM52987((6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50012987(6-(2-Hydroxy-ethyl)-5,6,6a,7-tetrahydro-4H-dibenzo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223517(CHEMBL285414)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223520(CHEMBL284248)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM84636(CHEMBL27559 | NPA-11-OH-R,(+))
Affinity DataIC50:  36nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223518(CHEMBL36061)
Affinity DataIC50:  112nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223519(CHEMBL32330)
Affinity DataIC50:  143nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223514(CHEMBL286929)
Affinity DataIC50:  204nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332301((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50007422((+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Affinity DataIC50:  280nMAssay Description:Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332301((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223516(CHEMBL283871)
Affinity DataIC50:  394nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332299(CHEMBL1287940 | methyl 4-(5-amino-1-(2,6-difluorob...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM52987((6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  600nMAssay Description:Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332298(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  610nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50007422((+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Affinity DataIC50:  670nMAssay Description:Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332298(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  690nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223513(CHEMBL440846)
Affinity DataIC50:  700nMAssay Description:Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM84636(CHEMBL27559 | NPA-11-OH-R,(+))
Affinity DataIC50:  700nMAssay Description:Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223503(CHEMBL35556)
Affinity DataIC50:  725nMAssay Description:Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332299(CHEMBL1287940 | methyl 4-(5-amino-1-(2,6-difluorob...)
Affinity DataIC50:  760nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  850nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  860nMAssay Description:Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50223517(CHEMBL285414)
Affinity DataIC50:  900nMAssay Description:Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332297(CHEMBL1287812 | ethyl 3-(5-amino-1-(2,6-difluorobe...)
Affinity DataIC50:  990nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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