Compile Data Set for Download or QSAR
maximum 50k data
Found 1229 with Last Name = 'lee' and Initial = 'js'
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)
Affinity DataKi:  0.270nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails PDB3D3D Structure (crystal)
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.840nMAssay Description:In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50182020(2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-m...)
Affinity DataKi:  1.10nMAssay Description:Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069035((7R,9aS)-7-Phenoxymethyl-2-phenyl-octahydro-pyrido...)
Affinity DataKi:  1.60nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069036((7S,9aS)-7-Phenoxymethyl-2-pyrimidin-2-yl-octahydr...)
Affinity DataKi:  1.70nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069036((7S,9aS)-7-Phenoxymethyl-2-pyrimidin-2-yl-octahydr...)
Affinity DataKi:  1.70nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069037((7R,9aS)-7-Phenoxymethyl-2-pyridin-2-yl-octahydro-...)
Affinity DataKi:  1.70nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069039((7S,9aS)-7-(4-Fluoro-phenoxymethyl)-2-(5-fluoro-py...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069048((7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-pyrimidin-2-...)
Affinity DataKi:  2.80nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataKi:  3.11nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069034((7R,9aS)-2-(5-Chloro-pyridin-2-yl)-7-(4-fluoro-phe...)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.30nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041((7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-(5-fluoro-py...)
Affinity DataKi:  3.40nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069047((7R,9aS)-7-Phenoxymethyl-2-pyrimidin-2-yl-octahydr...)
Affinity DataKi:  3.5nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069038(7-Phenoxymethyl-2-pyrimidin-2-yl-octahydro-pyrido[...)
Affinity DataKi:  3.80nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126226(3-[5-(4-Cyano-benzoyl)-1-methyl-1H-pyrrol-2-yl]-N-...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50070476((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(2,6-difluoro-p...)
Affinity DataKi:  5nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069042((7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-(4-fluoro-ph...)
Affinity DataKi:  5.30nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496900(science.abl4784, 4)
Affinity DataKi:  7.93nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126231(2-[5-(4-Cyano-benzoyl)-1-ethyl-1H-pyrrol-2-yl]-N-[...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496901(science.abl4784, 5)
Affinity DataKi:  12nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50070473((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(2,4-difluoro-p...)
Affinity DataKi:  12nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126252(CHEMBL283394 | N-[2,4-Dichloro-3-(2-methyl-quinoli...)
Affinity DataKi:  15nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069043((7R,9aS)-7-(4-Methoxy-phenoxymethyl)-2-pyrimidin-2...)
Affinity DataKi:  18nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126259(3-[5-(4-Cyano-benzoyl)-1-methyl-1H-pyrrol-2-yl]-N-...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069049((7R,9aS)-7-(4-tert-Butyl-phenoxymethyl)-2-pyrimidi...)
Affinity DataKi:  20nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126253(2-[5-(4-Cyano-benzoyl)-1-methyl-1H-pyrrol-2-yl]-N-...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126238(2-[5-(4-Cyano-benzoyl)-1-propyl-1H-pyrrol-2-yl]-N-...)
Affinity DataKi:  27nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496896(US11312704, Compound 101 | US11351149, Example 49 ...)
Affinity DataKi:  28nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126263(2-[1-Butyl-5-(4-cyano-benzoyl)-1H-pyrrol-2-yl]-N-[...)
Affinity DataKi:  29nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126242(CHEMBL280869 | N-[2,4-Dichloro-3-(2-methyl-quinoli...)
Affinity DataKi:  34nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50182020(2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-m...)
Affinity DataKi:  34nMAssay Description:Binding affinity to 5HT2B receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069036((7S,9aS)-7-Phenoxymethyl-2-pyrimidin-2-yl-octahydr...)
Affinity DataKi:  38nMAssay Description:In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069036((7S,9aS)-7-Phenoxymethyl-2-pyrimidin-2-yl-octahydr...)
Affinity DataKi:  38nMAssay Description:In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126229(3-[5-(6-Chloro-pyridine-3-carbonyl)-1-methyl-1H-py...)
Affinity DataKi:  38nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126251(2-[5-(4-Cyano-benzoyl)-1H-pyrrol-2-yl]-N-[2,4-dich...)
Affinity DataKi:  38nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069044((7R,9aR)-7-(4-Fluoro-phenoxymethyl)-2-(5-fluoro-py...)
Affinity DataKi:  39nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069035((7R,9aS)-7-Phenoxymethyl-2-phenyl-octahydro-pyrido...)
Affinity DataKi:  44nMAssay Description:In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126230(2-[5-(4-Cyano-benzoyl)-1-(3-methyl-butyl)-1H-pyrro...)
Affinity DataKi:  44nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  47nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126228(2-[5-(4-Cyano-benzoyl)-1-methyl-1H-pyrrol-2-yl]-N-...)
Affinity DataKi:  55nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126233(2-[5-(4-Acetylamino-benzoyl)-1-methyl-1H-pyrrol-2-...)
Affinity DataKi:  57nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069039((7S,9aS)-7-(4-Fluoro-phenoxymethyl)-2-(5-fluoro-py...)
Affinity DataKi:  68nMAssay Description:In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126260(2-[5-(4-Cyano-benzoyl)-1-methyl-1H-pyrrol-2-yl]-N-...)
Affinity DataKi:  69nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126255(2-[5-(3-Acetylamino-benzoyl)-1-methyl-1H-pyrrol-2-...)
Affinity DataKi:  73nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126246(2-[5-(6-Cyano-pyridine-3-carbonyl)-1-methyl-1H-pyr...)
Affinity DataKi:  74nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126250(CHEMBL26192 | N-[2,4-Dichloro-3-(2-methyl-quinolin...)
Affinity DataKi:  76nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126241(CHEMBL27702 | N-[2,4-Dichloro-3-(2-methyl-quinolin...)
Affinity DataKi:  92nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50126262(2-[5-(6-Cyano-pyridine-3-carbonyl)-1-methyl-1H-pyr...)
Affinity DataKi:  103nMAssay Description:Binding affinity towards human bradykinin receptor B2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069045((7S,9aR)-7-(4-Fluoro-phenoxymethyl)-2-(5-fluoro-py...)
Affinity DataKi:  106nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]-spiperone displacment.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 1229 total ) | Next | Last >>
Jump to: