Compile Data Set for Download or QSAR
maximum 50k data
Found 788 with Last Name = 'lucas' and Initial = 'bj'
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292202(CHEMBL382542 | N-(2-Aminomethyl-5-chloro-benzyl)-2...)
Affinity DataKi:  0.00100nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147818((2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-...)
Affinity DataKi:  0.00140nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147824(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.00150nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292203(CHEMBL196030 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.00200nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133524(CHEMBL419773 | N-(2-Aminomethyl-5-chloro-benzyl)-2...)
Affinity DataKi:  0.00340nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147793(CHEMBL323583 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.0130nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337452(2-(4-chloro-2-((2-(6-methyl-2-oxo-3-(2-(pyridin-2-...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147788(CHEMBL103874 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.0180nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131480((S)-20-Benzyl-8,25-dichloro-18-methyl-12-oxa-1,4,1...)
Affinity DataKi:  0.0200nMAssay Description:Inhibitory activity against thrombin IIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147809(CHEMBL103342 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.0330nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172842(CHEMBL198820 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172826(CHEMBL426101 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292196(CHEMBL195366 | N-(2-Aminomethyl-5-chloro-benzyl)-2...)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122190(CHEMBL296737 | N-(5-chloro-2-ethylcarbamoylmethoxy...)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122190(CHEMBL296737 | N-(5-chloro-2-ethylcarbamoylmethoxy...)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123490(CHEMBL143418 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.0420nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133529(CHEMBL420682 | N-(2-Aminomethyl-5-chloro-benzyl)-2...)
Affinity DataKi:  0.0460nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292200(2-[3-Chloro-6-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147812(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131460((S)-20-Benzyl-8,25-dichloro-12-oxa-1,4,18,21,23-pe...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitory activity against thrombin IIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131464((S)-20-Benzyl-8,25-dichloro-12,15-dioxa-1,4,18,21,...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitory activity against thrombin IIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133521(CHEMBL116202 | N-[2-(2-Amino-ethyl)-5-chloro-benzy...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057826((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  0.0560nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172829(CHEMBL198735 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131471((14Z,21S)-21-benzyl-8,26-dichloro-12,17-dioxa-1,4,...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory activity against thrombin IIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122183(CHEMBL431524 | N-(5-Chloro-2-ethylcarbamoylmethoxy...)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172841((2-{2-[2-(5-Chloro-2-[1,2,4]triazol-1-yl-benzyl)-o...)
Affinity DataKi:  0.0700nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292189(2-[2-(3-Chloro-benzylamino)-2-hydroxy-ethyl]-6-(2,...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172839(CHEMBL197668 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50088653(CHEMBL274152 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.0840nMAssay Description:The compound was tested for its ability to inhibit thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147801(CHEMBL102122 | N-(5-Chloro-2-[1,2,4]triazol-1-yl-b...)
Affinity DataKi:  0.0850nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126304(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.0870nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131470((11S)-11-BENZYL-6-CHLORO-1,2,10,11,12,13,14,15,16,...)
Affinity DataKi:  0.0900nMAssay Description:Inhibitory activity against thrombin IIaMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50454822(CHEMBL2062141 | L-370518)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147821(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.0960nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123504(CHEMBL142546 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063555(1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057827(((R)-2-{(S)-2-[(4-Amino-cyclohexylmethyl)-carbamoy...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337453(2-(4-chloro-2-((2-(6-methyl-2-oxo-3-(2-(pyridin-2-...)
Affinity DataKi:  0.125nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133520(CHEMBL116258 | N-(2-Aminomethyl-5-chloro-benzyl)-2...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131473((S)-20-Benzyl-8,25-dichloro-12-oxa-1,4,19,21,23-pe...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against thrombin IIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147822(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292201(CHEMBL372367 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172831(CHEMBL198978 | [2-(5-Chloro-2-[1,2,4]triazol-1-yl-...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172845((2-{2-[2-(5-Chloro-2-[1,2,4]triazol-1-yl-benzyl)-o...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126303(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147810(CHEMBL100854 | N-(5-Chloro-2-[1,2,4]triazol-1-yl-b...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50131458((14E,21S)-21-benzyl-8,26-dichloro-12,17-dioxa-1,4,...)
Affinity DataKi:  0.170nMAssay Description:Inhibitory activity against thrombin IIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 788 total ) | Next | Last >>
Jump to: