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Found 200 with Last Name = 'mavel' and Initial = 's'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]IPT from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50154365(2-(2-((dimethylamino)methyl)phenoxy)-5-iodoaniline...)
Affinity DataKi:  0.171nMAssay Description:Displacement of [3H]citalopram from human cloned SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Cnrs Upr 4301

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50178936(2-(2-((dimethylamino)methyl)phenoxy)-5-methylbenze...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]paroxetine from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50363762(CHEMBL1947088)
Affinity DataKi:  0.870nMAssay Description:Displacement of [3H]WIN35428 from human cloned DAT receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264817(CHEMBL491028 | N-(5-chloro-2-(2-((dimethylamino)me...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]IDAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110782(CHEMBL429065 | [5-Iodo-2-(2-methylaminomethyl-phen...)
Affinity DataKi:  0.980nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110780(5-Iodo-2-(2-methylaminomethyl-phenylsulfanyl)-phen...)
Affinity DataKi:  1.25nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110777(5-Bromo-2-(2-methylaminomethyl-phenylsulfanyl)-phe...)
Affinity DataKi:  1.49nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.65nMAssay Description:Displacement of [3H]citalopram from human cloned SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.65nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.65nMAssay Description:Displacement of [3H]paroxetine from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50073438(CHEMBL278165 | [5-Bromo-2-(2-dimethylaminomethyl-p...)
Affinity DataKi:  1.92nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110781(5-Bromo-2-(2-dimethylaminomethyl-phenylsulfanyl)-p...)
Affinity DataKi:  2.23nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110784(CHEMBL284002 | [2-(4-Iodo-2-methoxymethyl-phenylsu...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110786(CHEMBL22259 | [2-(4-Bromo-2-methoxymethyl-phenylsu...)
Affinity DataKi:  2.75nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Cnrs Upr 4301

Curated by ChEMBL
LigandPNGBDBM50464766(CHEMBL4292287)
Affinity DataKi:  3nMAssay Description:Reversible competitive inhibition of human cathepsin K using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50329778((-)-(R,R)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2...)
Affinity DataKi:  3.57nMAssay Description:Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Rattus norvegicus)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50329778((-)-(R,R)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2...)
Affinity DataKi:  3.68nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50178934(2-(2-((dimethylamino)methyl)phenylsulfinyl)-5-meth...)
Affinity DataKi:  4.15nMAssay Description:Displacement of [3H]paroxetine from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Cnrs Upr 4301

Curated by ChEMBL
LigandPNGBDBM50464766(CHEMBL4292287)
Affinity DataKi:  5nMAssay Description:Reversible competitive inhibition of human cathepsin L using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50073438(CHEMBL278165 | [5-Bromo-2-(2-dimethylaminomethyl-p...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of [3H]-nisoxatine binding to norepinephrine transporter (NET) of rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Rattus norvegicus)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50329777((+)-(S,S)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2...)
Affinity DataKi:  6.95nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50308670(CHEMBL589178 | N,N-Dimethyl-5-(3-fluoropropoxy)-2-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]citalopram from human cloned SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50308666(4-Fluoro-N,N-dimethyl-2-(2-amino-4-methylphenoxy)-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]citalopram from human cloned SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110783(CHEMBL22743 | [2-(2-Dimethylaminomethyl-phenylsulf...)
Affinity DataKi:  7.96nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50218672(2-(2-((dimethylamino)methyl)-4-fluorophenoxy)-5-me...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]citalopram from human cloned SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264818(CHEMBL490416 | N-(5-bromo-2-(2-((dimethylamino)met...)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]IDAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Cnrs Upr 4301

Curated by ChEMBL
LigandPNGBDBM50464764(CHEMBL4287663)
Affinity DataKi:  9nMAssay Description:Reversible competitive inhibition of human cathepsin K using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265295(CHEMBL497140 | N,N-Dimethyl-2-[2-(N-4-fluorobenzyl...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50178935(CHEMBL383422 | N1-(2-((dimethylamino)methyl)phenyl...)
Affinity DataKi:  10.3nMAssay Description:Displacement of [3H]paroxetine from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Rattus norvegicus)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50329776((rac)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2,3,4...)
Affinity DataKi:  10.9nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50308671(CHEMBL589179 | N,N-Dimethyl-5-(4-fluorobutoxy)-2-(...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]citalopram from human cloned SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50020316(CHEMBL3289177)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nicotinic acetylcholine receptor in Wistar rat frontal cortex by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110782(CHEMBL429065 | [5-Iodo-2-(2-methylaminomethyl-phen...)
Affinity DataKi:  12.8nMAssay Description:Inhibition of [3H]-nisoxatine binding to norepinephrine transporter (NET) of rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50308665(4-Fluoro-N,N-dimethyl-2-(2-amino-4-methylphenylthi...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]citalopram from human cloned SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50329776((rac)-5-Fluoro-3-(4-phenyl-piperidin-1-yl)-1,2,3,4...)
Affinity DataKi:  13.2nMAssay Description:Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat cortical membranes after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265291(CHEMBL525371 | N,N-Dimethyl-2-[2-(N-4-fluorobenzam...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50020317(CHEMBL3289178)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]-alpha-bungarotoxin from alpha7 nicotinic acetylcholine receptor in Wistar rat frontal cortex by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Rattus norvegicus)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50329775((2R,3R)-5-Iodo-3-(4-phenyl-piperidin-1-yl)-1,2,3,4...)
Affinity DataKi:  15.8nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Cnrs Upr 4301

Curated by ChEMBL
LigandPNGBDBM50464766(CHEMBL4292287)
Affinity DataKi:  17nMAssay Description:Reversible competitive inhibition of human cathepsin S using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity at ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50296782((1R,2S,3S,5S)-methyl 8-((E)-3-iodoallyl)-3-p-tolyl...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]WIN35428 from human cloned DAT receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110787(2-(2-{[(2-Fluoro-ethyl)-methyl-amino]-methyl}-phen...)
Affinity DataKi:  19.3nMAssay Description:Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Rattus norvegicus)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50329773((-)-(2R,3R)-5-(2-fluoroethoxy)-3-(4-phenylpiperidi...)
Affinity DataKi:  19.6nMAssay Description:Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Cnrs Upr 4301

Curated by ChEMBL
LigandPNGBDBM50464766(CHEMBL4292287)
Affinity DataKi:  26nMAssay Description:Reversible competitive inhibition of human cathepsin S using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity at ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110783(CHEMBL22743 | [2-(2-Dimethylaminomethyl-phenylsulf...)
Affinity DataKi:  28.4nMAssay Description:Inhibition of [3H]-nisoxatine binding to norepinephrine transporter (NET) of rat cortical homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264816(CHEMBL491027 | N-(2-(2-((dimethylamino)methyl)phen...)
Affinity DataKi:  34nMAssay Description:Displacement of [125I]IDAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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