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Found 1387 with Last Name = 'meegalla' and Initial = 'sk'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50055824(2-{[(2R,3S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  7nMAssay Description:In vitro binding affinity to Dopamine transporter in rat striatal homogenates using [125I]-IPT20 as the ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062680(2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[...)
Affinity DataKi:  8.42nMAssay Description:In vitro bindingaffinity towards dopamine transporter in rat striatal homogenatewith [125I]-IPT as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50062679(2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[...)
Affinity DataKi:  13.9nMAssay Description:In vitro bindingaffinity towards dopamine transporter in rat striatal homogenatewith [125I]-IPT as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50055825(CHEMBL295441 | Rhenium Compound)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity of the compound towards dopamine transporter using [125I]-IPT20 as radioligand in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335165(3-[2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-tr...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377072(CHEMBL438533)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377072(CHEMBL438533)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321368(4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321373(4-cyano-N-(4-(2-(cyanoimino)-1,3-dimethylhexahydro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM97732(US8481564, 8)
Affinity DataIC50:  0.400nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377071(CHEMBL402337)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  0.413nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of cold-induced channel current by whole cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238106(US9394289, 2)
Affinity DataIC50:  0.420nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM97739(US8481564, 54)
Affinity DataIC50:  0.420nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM119049(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Affinity DataIC50:  0.440nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198857(BDBM198884 | US9221797, 20)
Affinity DataIC50:  0.440nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238129(US9394289, 25)
Affinity DataIC50:  0.490nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321365(4-cyano-N-(2-cyclohexenyl-4-(1-methyl-2,6-dioxopip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238109(US9394289, 5)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321367(4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM119049(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Affinity DataIC50:  0.510nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198857(BDBM198884 | US9221797, 20)
Affinity DataIC50:  0.510nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238121(US9394289, 17)
Affinity DataIC50:  0.560nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193240(US9193736, 164)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198873(US9221797, 45)
Affinity DataIC50:  0.600nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335170(3-[5-(2-Fluoro-6-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50443154(CHEMBL3085973 | US8674100, 147)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM119032(US8674100, 45)
Affinity DataIC50:  0.600nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM119049(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50233716(5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50393560(CHEMBL2158300 | US8697716, 48)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198904(US9221797, 147)
Affinity DataIC50:  0.640nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443154(CHEMBL3085973 | US8674100, 147)
Affinity DataIC50:  0.640nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50393549(CHEMBL2158289)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238225(US9403804, 2)
Affinity DataIC50:  0.650nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238111(US9394289, 7)
Affinity DataIC50:  0.670nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238120(US9394289, 16)
Affinity DataIC50:  0.670nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443167(CHEMBL3085977 | US8674100, 76)
Affinity DataIC50:  0.680nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198891(US9221797, 76)
Affinity DataIC50:  0.680nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM119044(CHEMBL3085833 | US8674100, 62 | US8674100, 63)
Affinity DataIC50:  0.690nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198878(BDBM198879 | US9221797, 62)
Affinity DataIC50:  0.690nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50355499(CHEMBL1908395 | CHEMBL1908842)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50355499(CHEMBL1908395 | CHEMBL1908842)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238105(US9394289, 1)
Affinity DataIC50:  0.700nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238138(US9394289, 35)
Affinity DataIC50:  0.700nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50233701(5-cyano-furan-2-carboxylic acid [4-(1,1-dioxo-1lam...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335160(2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-trifl...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50393562(CHEMBL2158302)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50443167(CHEMBL3085977 | US8674100, 76)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50233720(CHEMBL254909 | N-(4-(4-acetylpiperazin-1-yl)-2-(4-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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