Affinity DataKi: 0.470nMAssay Description:Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as...More data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Inhibition assay using matrix metalloproteinase (MMP-2).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 0.590nMAssay Description:Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as...More data for this Ligand-Target Pair
Affinity DataKi: 0.710nMAssay Description:Inhibition of human recombinant MMP-8 catalytic domain (99 to 269 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as s...More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Inhibition of APMA activated recombinant human full length MMP2 expressed in mouse cells using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substra...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of recombinant human MMP8 catalytic domain (Phe99 to Gln269 residues) expressed in Escherichia coli using McaKPLGL-Dpa-AR-NH2 as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Inhibition of human recombinant MMP-8 catalytic domain (99 to 269 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as s...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Competitive inhibition of human MMP9 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Inhibition of recombinant human MMP2 expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Inhibition of human recombinant MMP-2 using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of recombinant human MMP9 catalytic domain (Phe107 to Pro449 residues) expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)...More data for this Ligand-Target Pair
Affinity DataKi: 13.9nMAssay Description:Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Inhibition of human recombinant MMP-8 catalytic domain (99 to 269 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as s...More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Slow binding inhibition of human recombinant MMP9 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Inhibition of human recombinant MMP2 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as...More data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Inhibition of recombinant human MMP2More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of recombinant human MMP12 catalytic domain using Mca-PLGL-DpaAR-NH2 as substrate by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 34nMAssay Description:Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as...More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Competitive inhibition of human MMP14 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Slow binding inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Competitive inhibition of human MMP9 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Inhibition of human recombinant MMP-2 using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 53nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 61nMAssay Description:Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 61nMAssay Description:Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
University Of Notre Dame
Curated by ChEMBL
University Of Notre Dame
Curated by ChEMBL
Affinity DataKi: 61nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged ADAM17 (Arg215 to Asn671 residues) expressed in baculovirus infected Sf21 cells using Mca-PLAQ...More data for this Ligand-Target Pair
Affinity DataKi: 62nMAssay Description:Inhibition of human recombinant MMP2 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Inhibition assay using matrix metalloproteinase (MMP-2).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 68nMAssay Description:Inhibition of recombinant human MMP14 catalytic domain (89 to 265 residues) expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-A...More data for this Ligand-Target Pair
Affinity DataKi: 69nMAssay Description:Inhibition of human recombinant MMP2 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
University Of Notre Dame
Curated by ChEMBL
University Of Notre Dame
Curated by ChEMBL
Affinity DataKi: 73nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged ADAM10 (Thr214 to Glu672 residues) expressed in baculovirus infected Sf21 cells using McaKPLG...More data for this Ligand-Target Pair
Affinity DataKi: 75nMAssay Description:Inhibition of recombinant human MMP7 expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate by fluorescence spe...More data for this Ligand-Target Pair
Affinity DataKi: 78nMAssay Description:Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 85nMAssay Description:Slow binding inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Competitive inhibition of human MMP14 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 93nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 119nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Slow binding inhibition of human recombinant MMP14 catalytic domain using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 substrateMore data for this Ligand-Target Pair