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Found 107 with Last Name = 'mueller' and Initial = 'ra'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50010495(Acetyl-Ser-Leu-Asn-Phe-[CH(OH)CH2N]Pro-Ile-Val-OMe...)
Affinity DataKi:  0.600nMAssay Description:In vitro binding affinity of the compound against HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50010497(Acetyl-Ser-Leu-Asn-Phe-[S]-[CH(OH)CH2N]Pro-Ile-Val...)
Affinity DataKi:  20nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measured (exp 2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50010497(Acetyl-Ser-Leu-Asn-Phe-[S]-[CH(OH)CH2N]Pro-Ile-Val...)
Affinity DataKi:  20nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023523(2,2-Dimethyl-propionic acid 2-[2,4-bis-(2,2-dimeth...)
Affinity DataKi:  68nMAssay Description:Binding affinity towards human leukocyte elastase at 10e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023518(2,4-Bis-(2,2-dimethyl-propionyloxy)-benzoic acid 5...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023545(2,2-Dimethyl-propionic acid 4-[4-(2,2-dimethyl-pro...)
Affinity DataKi:  71nMAssay Description:Binding affinity towards human leukocyte elastase at 10e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023542(2,2-Dimethyl-propionic acid 4-[4-(2,2-dimethyl-pro...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50011680(CHEMBL3351098 | Qua-Asn-Phe-HEA(S)-Pro-Ile-Phe-OMe)
Affinity DataIC50:  2.30nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM486((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(3-methylb...)
Affinity DataIC50:  3nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM490((2S)-N-[(2S,3R)-4-[benzyl(tert-butylcarbamoyl)amin...)
Affinity DataIC50:  3nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50011684(CHEMBL3350878 | Cbz-Asn-Phe-HEA(S)-Pro-Ile-Phe-OMe)
Affinity DataIC50:  4nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM488((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(cyclohexy...)
Affinity DataIC50:  5nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM483((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(2-methylp...)
Affinity DataIC50:  6nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50010495(Acetyl-Ser-Leu-Asn-Phe-[CH(OH)CH2N]Pro-Ile-Val-OMe...)
Affinity DataIC50:  9nMAssay Description:In vitro binding affinity of the compound against HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM485((Hydroxyethyl)urea Isostere deriv. 13 | benzyl N-[...)
Affinity DataIC50:  13nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50011687(Ac-Ser-Leu-Asn-Phe-HEA(R)-Pro-O-terbutyl | CHEMBL3...)
Affinity DataIC50:  14nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50011682(Ac-Ser-Leu-Asn-Phe-HEA(S)-Pro-O-terbutyl | BDBM504...)
Affinity DataIC50:  14nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50011688(Boc-Asn-Phe-HEA(R)-Pro-Ile-Val-OMe | CHEMBL3349554)
Affinity DataIC50:  16nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM494((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(pyridin-4...)
Affinity DataIC50:  19nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM489((Hydroxyethyl)urea Isostere deriv. 17 | benzyl N-[...)
Affinity DataIC50:  19nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023523(2,2-Dimethyl-propionic acid 2-[2,4-bis-(2,2-dimeth...)
Affinity DataIC50:  27nMAssay Description:Binding affinity towards human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023518(2,4-Bis-(2,2-dimethyl-propionyloxy)-benzoic acid 5...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM487((Hydroxyethyl)urea Isostere deriv. 15 | benzyl N-[...)
Affinity DataIC50:  29nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM481((Hydroxyethyl)urea Isostere deriv. 9 | benzyl N-[(...)
Affinity DataIC50:  35nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50005687(1-[3-(2-Benzyloxycarbonylamino-3-carbamoyl-propion...)
Affinity DataIC50:  51nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measured (exp 2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023517(2,2-Dimethyl-propionic acid 5-(2,2-dimethyl-propio...)
Affinity DataIC50:  55nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-5 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50010497(Acetyl-Ser-Leu-Asn-Phe-[S]-[CH(OH)CH2N]Pro-Ile-Val...)
Affinity DataIC50:  65nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50010497(Acetyl-Ser-Leu-Asn-Phe-[S]-[CH(OH)CH2N]Pro-Ile-Val...)
Affinity DataIC50:  65nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023522(CHEMBL9969 | Octadecanoic acid 5-isobutyryloxy-4-o...)
Affinity DataIC50:  72nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023542(2,2-Dimethyl-propionic acid 4-[4-(2,2-dimethyl-pro...)
Affinity DataIC50:  83nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023550(2,2-Dimethyl-propionic acid 2-benzoyl-5-(2,2-dimet...)
Affinity DataIC50:  84nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023569(3,4,5-Tris-(2,2-dimethyl-propionyloxy)-benzoic aci...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023555(CHEMBL9809 | Octadecanoic acid 5-(2,2-dimethyl-pro...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM493((Hydroxyethyl)urea Isostere deriv. 21 | benzyl N-[...)
Affinity DataIC50:  105nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023570(CHEMBL9895 | Hexadecanoic acid 5-(2,2-dimethyl-pro...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023545(2,2-Dimethyl-propionic acid 4-[4-(2,2-dimethyl-pro...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM477((2S)-N-[(2S,3R)-4-[(butylcarbamoyl)(2-methylpropyl...)
Affinity DataIC50:  126nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023551(CHEMBL9865 | Hexadec-9-enoic acid 5-(2,2-dimethyl-...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023558(CHEMBL9978 | Icosanoic acid 5-(2,2-dimethyl-propio...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023540(2,2-Dimethyl-propionic acid 4-[4-(2,2-dimethyl-pro...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023547(2,2-Dimethyl-propionic acid 4-(4-chloro-benzoyl)-p...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50005687(1-[3-(2-Benzyloxycarbonylamino-3-carbamoyl-propion...)
Affinity DataIC50:  140nMAssay Description:In vitro concentration of the compound required to inhibit 50% activity of HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023566(CHEMBL269669 | Isobutyric acid 4-(4-isobutyryloxy-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023529(CHEMBL9644 | Docos-13-enoic acid 5-(2,2-dimethyl-p...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023511(2,2-Dimethyl-propionic acid 4-benzoyl-2-(2-carboxy...)
Affinity DataIC50:  170nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-6 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023549(4-(2,2-Dimethyl-propionyloxy)-benzoic acid 5-(2,2-...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023562(CHEMBL9792 | Icos-11-enoic acid 5-(2,2-dimethyl-pr...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023525(CHEMBL10348 | Isobutyric acid 4-benzoyl-phenyl est...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM480((Hydroxyethyl)urea Isostere deriv. 8 | benzyl N-[(...)
Affinity DataIC50:  260nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023552(CHEMBL9802 | Octadec-9-enoic acid 5-(2,2-dimethyl-...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human leukocyte elastase at 10e-7 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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