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Found 390 with Last Name = 'pescatore' and Initial = 'g'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309361(2-(4-(5-((6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309350(4-(3-(4-(azetidin-1-yl)piperidine-1-carbonyl)-4-fl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309357(6,7-dichloro-4-(4-fluoro-3-(4-(quinazolin-2-yl)pip...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309375(6,7-dichloro-4-(4-fluoro-3-(4-pivaloylpiperazine-1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309393(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)-7-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309356(6,7-dichloro-4-(4-fluoro-3-(4-(quinazolin-4-yl)pip...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309391(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)-7,...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309394(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)-7-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309395(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pyr...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309358(6,7-dichloro-4-(4-fluoro-3-(4-(isoquinolin-3-yl)pi...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Merck Research Laboratories

LigandPNGBDBM25330(2-[4-(dimethylamino)oxan-4-yl]-N-[(4-fluorophenyl)...)
Affinity DataIC50:  2nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309368(2-(4-(5-((6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258324((S)-1-methyl-N-(7-oxo-1-(5-(quinolin-6-yl)-1H-imid...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human C-terminal FLAG-tagged HDAC1 in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309376(6,7-dichloro-4-(4-fluoro-3-(4-isobutyrylpiperazine...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309387(6,7-dichloro-4-(4-fluoro-3-(piperazine-1-carbonyl)...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309354(6,7-dichloro-4-(4-fluoro-3-(4-(methylamino)piperid...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309369(4-(5-((6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309373(6,7-dichloro-4-(4-fluoro-3-(4-picolinoylpiperazine...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309221(6,7-dichloro-4-(4-fluoro-3-(1,8-diazaspiro[4.5]dec...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309367(6,7-dichloro-4-(3-(4-(2-(dimethylamino)acetyl)pipe...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309353(6,7-dichloro-4-(3-(4-(dimethylamino)piperidine-1-c...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309392(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)-6,...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309364(6,7-dichloro-4-(4-fluoro-3-(4-(pyridin-2-yl)pipera...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183190(2-(1-(2-bromo-4-methylphenyl)-1H-tetrazol-5-ylthio...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Merck Research Laboratories

LigandPNGBDBM25329(N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-[2...)
Affinity DataIC50:  3nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Merck Research Laboratories

LigandPNGBDBM22682(Bicyclic pyrimidinone, 15b | N-[(4-fluorophenyl)me...)
Affinity DataIC50:  3nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183196(2-(1-mesityl-1H-tetrazol-5-ylthio)-N-(2-nitropheny...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183217(CHEMBL206522 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183200(3-chloro-4-(2-(1-mesityl-1H-tetrazol-5-ylthio)acet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183199(2-(1-(3-chloro-2-methylphenyl)-1H-tetrazol-5-ylthi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309362(6,7-dichloro-4-(4-fluoro-3-(4-(pyrimidin-2-yl)pipe...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309372(4-(3-(4-(1H-imidazole-2-carbonyl)piperazine-1-carb...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309377(6,7-dichloro-4-(4-fluoro-3-(4-propionylpiperazine-...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309374(6,7-dichloro-4-(3-(4-(cyclopentanecarbonyl)piperaz...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Merck Research Laboratories

LigandPNGBDBM22673(9-[benzyl(methyl)amino]-N-[(4-fluorophenyl)methyl]...)
Affinity DataIC50:  4nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258577((S)-1-methyl-N-(7-oxo-1-(5-(quinolin-3-yl)-1H-imid...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human C-terminal FLAG-tagged HDAC1 in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Merck Research Laboratories

LigandPNGBDBM25352(N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-{2...)
Affinity DataIC50:  4nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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