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Found 253 with Last Name = 'petrounia' and Initial = 'ip'
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14192(3-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}a...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14208(3-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14209(4-(4-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50:  0.800nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14209(4-(4-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: <1nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of poly(Glu:Tyr) by purified recombinant human FLT3. The extent of phospho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375155(CHEMBL256893)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50371914(CHEMBL403661)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50371915(CHEMBL273198)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375139(CHEMBL256459)
Affinity DataIC50:  3nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14201(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-phenyl-7H-p...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375138(CHEMBL402852)
Affinity DataIC50:  4nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375145(CHEMBL271461)
Affinity DataIC50:  5nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14207(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-2-...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14203(7-(3-methoxyphenyl)-N-[3-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14191(N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375159(CHEMBL255794)
Affinity DataIC50:  7nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375158(CHEMBL404188)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375144(CHEMBL255584)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375142(CHEMBL257528)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14197(7-(3-methanesulfonylphenyl)-N-[4-(4-methylpiperazi...)
Affinity DataIC50:  9nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14200(7-(3-methanesulfonylphenyl)-N-[3-(4-methylpiperazi...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14205(3-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375157(CHEMBL273193)
Affinity DataIC50:  12nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14199(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14193(4-[4-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-y...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  13nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14202(3-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14196(N-[4-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27889(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375155(CHEMBL256893)
Affinity DataIC50:  14nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375155(CHEMBL256893)
Affinity DataIC50:  14nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223693(5-cyano-N-(2,5-di(piperidin-1-yl)phenyl)furan-2-ca...)
Affinity DataIC50:  17nMAssay Description:Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223698(5-cyano-N-(5-hydroxy-2-(piperidin-1-yl)phenyl)fura...)
Affinity DataIC50:  17nMAssay Description:Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14195(7-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14198(7-(2,3-dihydro-1H-inden-2-yl)-N-[4-(4-methylpipera...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223670(5-cyano-N-(5-((2,3-dihydroxypropoxy)methyl)-2-(pip...)
Affinity DataIC50:  19nMAssay Description:Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375140(CHEMBL256405)
Affinity DataIC50:  21nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375141(CHEMBL256406)
Affinity DataIC50:  22nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM17750(5-cyano-N-[5-(hydroxymethyl)-2-(4-methylpiperidin-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM17750(5-cyano-N-[5-(hydroxymethyl)-2-(4-methylpiperidin-...)
Affinity DataIC50:  24nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) was incubated with compound in reaction buffer. Control reactions were run in each plate. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223700(5-cyano-N-(5-(hydroxymethyl)-2-(piperidin-1-yl)phe...)
Affinity DataIC50:  25nMAssay Description:Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375155(CHEMBL256893)
Affinity DataIC50:  28nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14194(7-{bicyclo[2.2.1]heptan-2-yl}-N-[4-(4-methylpipera...)
Affinity DataIC50:  29nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 795 of Rb by purified recombinant CDK4. The phosphorylation of s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14204(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-[3-(propan-...)
Affinity DataIC50:  29nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM14189(7-cyclohexyl-N-[4-(4-methylpiperazin-1-yl)phenyl]-...)
Affinity DataIC50:  31nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 795 of Rb by purified recombinant CDK4. The phosphorylation of s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50375152(CHEMBL255182)
Affinity DataIC50:  31nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50371914(CHEMBL403661)
Affinity DataIC50:  34nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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