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Found 537 with Last Name = 'prasad' and Initial = 'jv'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM472(5-tert-butyl-4-{[(6S)-4-hydroxy-6-[2-(4-hydroxyphe...)
Affinity DataKi:  0.0300nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM430(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  0.0300nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM430(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  0.0300nM ΔG°:  -62.5kJ/molepH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50409174(CHEMBL169119)
Affinity DataKi:  0.0300nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM472(5-tert-butyl-4-{[(6S)-4-hydroxy-6-[2-(4-hydroxyphe...)
Affinity DataKi:  0.0300nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM465((6S)-3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfa...)
Affinity DataKi:  0.0700nMpH: 6.2Assay Description:Binding affinity of the compound towards HIV protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM465((6S)-3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfa...)
Affinity DataKi:  0.0700nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM465((6S)-3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfa...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity of the compound towards HIV protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2208((6S)-3-{[2-tert-butyl-4-(hydroxymethyl)-5-methylph...)
Affinity DataKi:  0.0900nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50078088((S)-3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-pheny...)
Affinity DataKi:  0.0900nMpH: 4.7Assay Description:Inhibitory activity of the compound was evaluated against human immunodeficiency virus type 1(HIV-1) protease at pH 4.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50078088((S)-3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-pheny...)
Affinity DataKi:  0.0900nMpH: 6.2Assay Description:In vitro binding affinity of the compound against HIV protease at pH 6.2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2204((3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsu...)
Affinity DataKi:  0.0900nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50368427(CHEMBL1790880 | CHEMBL3349491)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50216785(CHEMBL61756)
Affinity DataKi: <0.100nMpH: 4.7Assay Description:Inhibitory activity of the compound was evaluated against human immunodeficiency virus type 1(HIV-1) protease at pH 6.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50078087((S)-6-[2-(4-Amino-phenyl)-ethyl]-3-(2-tert-butyl-4...)
Affinity DataKi:  0.110nMpH: 6.2Assay Description:In vitro binding affinity of the compound against HIV protease at pH 6.2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2206((6S)-6-[2-(4-aminophenyl)ethyl]-3-{[2-tert-butyl-4...)
Affinity DataKi:  0.110nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2533(3-{[2-tert-butyl-4-(hydroxymethyl)-5-methylphenyl]...)
Affinity DataKi:  0.170nM ΔG°:  -58.0kJ/molepH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM469(CHEMBL2110206 | Dihydropyran-2-one deriv. 74 | N-(...)
Affinity DataKi:  0.200nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM469(CHEMBL2110206 | Dihydropyran-2-one deriv. 74 | N-(...)
Affinity DataKi:  0.200nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM402(CHEMBL354027 | Dihydropyran-2-one deriv. 7 | N-[5-...)
Affinity DataKi:  0.210nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM402(CHEMBL354027 | Dihydropyran-2-one deriv. 7 | N-[5-...)
Affinity DataKi:  0.210nM ΔG°:  -57.5kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50368430(CHEMBL1790874 | CHEMBL3349485)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM470(CHEMBL2110205 | Dihydropyran-2-one deriv. 75 | N-(...)
Affinity DataKi:  0.310nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM467((S)-N-(5-tert-Butyl-4-{4-hydroxy-6-[2-(4-hydroxyph...)
Affinity DataKi:  0.390nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM467((S)-N-(5-tert-Butyl-4-{4-hydroxy-6-[2-(4-hydroxyph...)
Affinity DataKi:  0.390nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50368420(CHEMBL1790890 | CHEMBL3349500)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM403(CHEMBL169391 | Dihydropyran-2-one deriv. 8 | N-[5-...)
Affinity DataKi:  0.410nM ΔG°:  -55.7kJ/mole IC50:  2.20nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM403(CHEMBL169391 | Dihydropyran-2-one deriv. 8 | N-[5-...)
Affinity DataKi:  0.410nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2536(6-Alkyl-6-phenethyldihydropyrone 13y | 6-[2-(4-ami...)
Affinity DataKi:  0.430nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50368409(CHEMBL1790877 | CHEMBL3349488)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM398(CHEMBL287361 | Dihydropyran-2-one deriv. 3 | N-[5-...)
Affinity DataKi:  0.530nM ΔG°:  -55.1kJ/mole IC50:  1.80nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM398(CHEMBL287361 | Dihydropyran-2-one deriv. 3 | N-[5-...)
Affinity DataKi:  0.530nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50010495(Acetyl-Ser-Leu-Asn-Phe-[CH(OH)CH2N]Pro-Ile-Val-OMe...)
Affinity DataKi:  0.600nMAssay Description:In vitro binding affinity of the compound against HIV protease was measuredMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50368429(CHEMBL1790875 | CHEMBL3349486)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM396(3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfanyl]-...)
Affinity DataKi:  0.670nM ΔG°:  -54.5kJ/mole IC50:  2.70nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM396(3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfanyl]-...)
Affinity DataKi:  0.670nMpH: 6.2Assay Description:Binding affinity of the compound towards HIV protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50368422(CHEMBL1790871 | CHEMBL3349482)
Affinity DataKi:  0.670nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM396(3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfanyl]-...)
Affinity DataKi:  0.670nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM464(5-tert-butyl-4-{[(6R)-4-hydroxy-2-oxo-6-(2-phenyle...)
Affinity DataKi:  0.700nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM464(5-tert-butyl-4-{[(6R)-4-hydroxy-2-oxo-6-(2-phenyle...)
Affinity DataKi:  0.700nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50368423(CHEMBL1790881 | CHEMBL3349492)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM421(CHEMBL169849 | Dihydropyran-2-one deriv. 26 | N-(5...)
Affinity DataKi:  0.830nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM421(CHEMBL169849 | Dihydropyran-2-one deriv. 26 | N-(5...)
Affinity DataKi:  0.830nM ΔG°:  -53.9kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50230041(CHEMBL3349496)
Affinity DataKi:  1nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM429(Dihydropyran-2-one deriv. 34 | N-(5-tert-butyl-4-{...)
Affinity DataKi:  1.04nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM448(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  1.10nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM448(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  1.10nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM448(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  1.10nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50368425(CHEMBL1790885 | CHEMBL3349495)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM423(CHEMBL263028 | Dihydropyran-2-one deriv. 28 | N-(5...)
Affinity DataKi:  1.40nM ΔG°:  -52.6kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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