Affinity DataKi: 0.00500nMAssay Description:Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 0.00550nMAssay Description:Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 0.00600nMAssay Description:Antagonist activity on agonist (U50,488) stimulated [35S]GTP-gamma-S, binding in cloned opioid receptor kappa 1More data for this Ligand-Target Pair
Affinity DataKi: 0.0130nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding to Opioid receptor mu 1 in Guinea pig caudate st...More data for this Ligand-Target Pair
Affinity DataKi: 0.0130nMAssay Description:Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 0.0200nMAssay Description:Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.0200nMAssay Description:Inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (U69593, kappa-receptor), in guinea pig caudate membranes.More data for this Ligand-Target Pair
Affinity DataKi: 0.0210nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding to Opioid receptor mu 1 in Guinea pig caudate st...More data for this Ligand-Target Pair
Affinity DataKi: 0.0260nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding to Opioid receptor mu 1 in Guinea pig caudate st...More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(MOUSE)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 0.0300nMAssay Description:Antagonist activity of compound on agonist stimulated [35S]GTP-gamma-S binding on delta-opioid receptorMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.0380nMAssay Description:Inhibition of [35S]GTP-gamma-S, binding from Opioid receptor kappa 1 in Guinea pig Caudate stimulated by U69,593More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.0380nMAssay Description:Inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (U69593, kappa-receptor), in guinea pig caudate membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.0390nMAssay Description:Inhibition of [35S]GTP-gamma-S, binding from Opioid receptor mu 1 in Guinea pig Caudate stimulated by DAMGOMore data for this Ligand-Target Pair
Affinity DataKi: 0.0390nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding to Opioid receptor mu 1 in Guinea pig caudate st...More data for this Ligand-Target Pair
Affinity DataKi: 0.0400nMAssay Description:Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM SNC-80 as the agonist ligand for delta-rec...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.0530nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
Affinity DataKi: 0.0620nMAssay Description:Ability to inhibit GTP-gamma-S binding to Opioid receptor delta 1 of guinea pig caudate.More data for this Ligand-Target Pair
Affinity DataKi: 0.0620nMAssay Description:The ability of compound to inhibit [35S]GTP-delta-S binding in guinea pig caudate stimulated by SNC80 (Opioid receptor delta 1) antagonistMore data for this Ligand-Target Pair
Affinity DataKi: 0.0620nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 0.0620nMAssay Description:Ability to inhibit binding of SNC80 to delta opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:[3H]-Cl-DPDPE competition binding assay using human cloned opioid receptor delta 1More data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Displacement of [125I]OXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM U69,593 as the agonist ligand for kappa-re...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding in Guinea pig caudate stimulated by U69,593 to O...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.180nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 0.217nMAssay Description:Compound was tested for its ability to displace [3H]DADLE from delta receptor in rat brain.More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 0.220nMAssay Description:Ability to displace [3H]U-69593 from kappa opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.220nMAssay Description:Displacement of [3H]DADLE from Opioid receptor delta 1More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(MOUSE)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 0.220nMAssay Description:Displacement of [3H]DADLE at delta-opioid receptorMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 0.220nMAssay Description:Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 0.240nMAssay Description:Displacement of [3H]DADLE from morphine-insensitive Opioid receptor delta 1 (presence of 50 nM morphine) of rat brain membranesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.280nMAssay Description:Binding affinity determined on Opioid receptor kappa 1 in Guinea pig brain membranes using radioligand [3H]U-69593More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 0.290nMAssay Description:Displacement of [3H]DADLE from Opioid receptor delta 1 of rat brain membranes (DAMGO quenching mu receptor)More data for this Ligand-Target Pair
Affinity DataKi: 0.290nMAssay Description:In vito concentration required to displace [3H]DAGO (Kd = 0.7 nM and concentration is 1.7 nM) from opioid receptor mu in rat brain membranes.More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [125I]OXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.312nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding in Guinea pig caudate stimulated by SMC-80 (Opio...More data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.320nMAssay Description:Binding affinity of compound for Opioid receptor kappa 1 was determined using [3H]U-69593 as radioligand from guinea pig caudateMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.320nMAssay Description:Binding affinity to opioid receptor kappa 1 of guinea pig brain, using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membranesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.320nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.320nMAssay Description:In vito concentration required to displace 9 (Kd = 1.6 nM and concentration is 1.8 nM) from opioid receptor kappa 1 in guinea brain membranes.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.330nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding in Guinea pig caudate stimulated by U69,593 to O...More data for this Ligand-Target Pair