Compile Data Set for Download or QSAR
maximum 50k data
Found 1122 with Last Name = 'shearer' and Initial = 'bg'
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086433(CHEMBL3426034)
Affinity DataKi:  0.300nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086438(CHEMBL3426039)
Affinity DataKi:  0.450nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086434(CHEMBL3426035)
Affinity DataKi:  0.700nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065807(CHEMBL552825 | N-(3-Aminomethyl-phenyl)-furan-2-ca...)
Affinity DataKi:  6.30nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065843(CHEMBL553081 | CHEMBL555715 | N-(3-Aminomethyl-phe...)
Affinity DataKi:  8.70nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065823(CHEMBL555794 | N-(3-Aminomethyl-phenyl)-2-methylsu...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065813(CHEMBL555584 | N-(3-Aminomethyl-phenyl)-2-fluoro-a...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50086425(CHEMBL3426030)
Affinity DataKi:  14nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065823(CHEMBL555794 | N-(3-Aminomethyl-phenyl)-2-methylsu...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme.More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065833(CHEMBL542432 | N-(4-Aminomethyl-phenyl)-acetamidin...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065842(CHEMBL540048 | N-(4-{[3-(1-Imino-ethyl)-benzylamin...)
Affinity DataKi:  42nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002865(CHEMBL230730)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002864(CHEMBL398183)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423009(CHEMBL230731)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065848(CHEMBL539793 | N-(4-Methylaminomethyl-phenyl)-acet...)
Affinity DataKi:  56nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002863(CHEMBL230732)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423013(CHEMBL395527)
Affinity DataKi:  87nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423011(CHEMBL267996)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002862(CHEMBL396220)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002860(CHEMBL231656)
Affinity DataKi:  112nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002868(CHEMBL230523)
Affinity DataKi:  115nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058459(2-Ethyl-1-phenyl-isothiourea; hydriodide | CHEMBL4...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065843(CHEMBL553081 | CHEMBL555715 | N-(3-Aminomethyl-phe...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423010(CHEMBL230259)
Affinity DataKi:  138nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065805(CHEMBL544788 | N-(3-Aminomethyl-benzyl)-acetamidin...)
Affinity DataKi:  140nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058469(1-(4-Chloro-phenyl)-2-ethyl-isothiourea; hydrochlo...)
Affinity DataKi:  140nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002858(CHEMBL230524)
Affinity DataKi:  145nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002859(CHEMBL396480)
Affinity DataKi:  158nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065807(CHEMBL552825 | N-(3-Aminomethyl-phenyl)-furan-2-ca...)
Affinity DataKi:  160nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002866(CHEMBL266741)
Affinity DataKi:  166nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065818(CHEMBL554201 | N-(4-Dimethylaminomethyl-phenyl)-ac...)
Affinity DataKi:  170nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058441(1-(2-Chloro-phenyl)-2-ethyl-isothiourea; hydrochlo...)
Affinity DataKi:  170nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058448(2-Ethyl-1-(2-methoxy-phenyl)-isothiourea; hydrochl...)
Affinity DataKi:  170nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002867(CHEMBL396481)
Affinity DataKi:  174nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058443(2-Ethyl-1-p-tolyl-isothiourea; hydrochloride | CHE...)
Affinity DataKi:  180nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065817(2-Amino-N-(3-aminomethyl-phenyl)-acetamidine | CHE...)
Affinity DataKi:  190nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058445(2-Ethyl-1-(4-phenoxy-phenyl)-isothiourea; hydriodi...)
Affinity DataKi:  190nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423012(CHEMBL266742)
Affinity DataKi:  191nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002869(CHEMBL230522)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058468(1-(4-Benzyloxy-phenyl)-2-ethyl-isothiourea; hydrio...)
Affinity DataKi:  210nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072297((S)-5-Acetimidoylamino-2-amino-pent | (S)-5-Acetim...)
Affinity DataKi:  230nMAssay Description:Inhibitory constant for the inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50289680(2-Amino-3-(2-guanidino-phenyl)-propionic acid | CH...)
Affinity DataKi:  250nMAssay Description:Inhibitory constant for the inhibition of human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058440(1-(2-Bromo-phenyl)-2-ethyl-isothiourea; hydriodide...)
Affinity DataKi:  250nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423008(CHEMBL230804)
Affinity DataKi:  251nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002870(CHEMBL266985)
Affinity DataKi:  269nMAssay Description:Displacement of [3H]BRL49653 from PPARgamma by scintillation proximity assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50289681(2-Amino-3-[2-(N'-methyl-guanidino)-phenyl]-propion...)
Affinity DataKi:  270nMAssay Description:Inhibitory constant for the inhibition of human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058447(2-Ethyl-1-(4-methoxy-phenyl)-isothiourea; hydriodi...)
Affinity DataKi:  290nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50065847(2-Fluoro-N-(3-hydroxymethyl-phenyl)-acetamidine | ...)
Affinity DataKi:  300nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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