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Found 47 with Last Name = 'sheehan' and Initial = 'mj'
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085666((2S,3S,4R,5R)-5-{6-(2,2-Diphenyl-ethylamino)-2-[2-...)
Affinity DataKi:  0.0300nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085674((2S,3S,4R,5R)-5-[2-(4-Amino-cyclohexylamino)-6-(2,...)
Affinity DataKi:  0.0500nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085671((2S,3S,4R,5R)-5-[6-(2,2-Diphenyl-ethylamino)-2-(2-...)
Affinity DataKi:  0.0800nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085668((2S,3S,4R,5R)-5-[6-Amino-2-((1R,2R)-2-hydroxy-cycl...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085662((2S,3S,4R,5R)-5-[6-(2,2-Diphenyl-ethylamino)-2-((1...)
Affinity DataKi:  0.160nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085661((2R,3R,4S,5R)-2-[6-Amino-2-((1R,2R)-2-hydroxy-cycl...)
Affinity DataKi:  0.800nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  1nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  1nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  1nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085664((2R,3R,4S,5R)-2-[6-Amino-2-((1S,2S)-2-hydroxy-cycl...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085663((2R,3R,4S,5R)-2-[2-Chloro-6-((R)-(S)-2-hydroxy-cyc...)
Affinity DataKi:  2nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085670((2S,3S,4R,5R)-5-(6-Amino-2-cyclopentylamino-purin-...)
Affinity DataKi:  2.20nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085672((2R,3R,4S,5R)-2-(6-Amino-2-cyclopentylamino-purin-...)
Affinity DataKi:  5.10nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085665((2S,3S,4R,5R)-5-[2-Cyclopentylamino-6-(2,2-dipheny...)
Affinity DataKi:  6.20nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085667((2R,3S,4R,5R)-2-Hydroxymethyl-5-{6-[(naphthalen-1-...)
Affinity DataKi:  9.40nMAssay Description:Agonistic activity against Adenosine A2A receptor on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  17nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085667((2R,3S,4R,5R)-2-Hydroxymethyl-5-{6-[(naphthalen-1-...)
Affinity DataKi:  24nMAssay Description:Agonistic activity against Adenosine A1 receptor on rat whole-brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085669((2R,3R,4S,5R)-2-{2-Cyclopentylamino-6-[(naphthalen...)
Affinity DataKi:  25nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085673((2R,3R,4S,5R)-2-[2-Cyclopentylamino-6-(2,2-dipheny...)
Affinity DataKi:  36nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085660((2R,3R,4S,5R)-2-{6-[2-(3-Chloro-phenyl)-ethylamino...)
Affinity DataKi:  39nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085670((2S,3S,4R,5R)-5-(6-Amino-2-cyclopentylamino-purin-...)
Affinity DataKi:  80nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085664((2R,3R,4S,5R)-2-[6-Amino-2-((1S,2S)-2-hydroxy-cycl...)
Affinity DataKi:  84nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085675((2S,3S,4R,5R)-5-[6-Amino-2-(1-ethyl-propylamino)-p...)
Affinity DataKi:  85nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085663((2R,3R,4S,5R)-2-[2-Chloro-6-((R)-(S)-2-hydroxy-cyc...)
Affinity DataKi:  171nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085668((2S,3S,4R,5R)-5-[6-Amino-2-((1R,2R)-2-hydroxy-cycl...)
Affinity DataKi:  260nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085671((2S,3S,4R,5R)-5-[6-(2,2-Diphenyl-ethylamino)-2-(2-...)
Affinity DataKi:  263nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085674((2S,3S,4R,5R)-5-[2-(4-Amino-cyclohexylamino)-6-(2,...)
Affinity DataKi:  369nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085662((2S,3S,4R,5R)-5-[6-(2,2-Diphenyl-ethylamino)-2-((1...)
Affinity DataKi:  390nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085672((2R,3R,4S,5R)-2-(6-Amino-2-cyclopentylamino-purin-...)
Affinity DataKi:  549nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085673((2R,3R,4S,5R)-2-[2-Cyclopentylamino-6-(2,2-dipheny...)
Affinity DataKi: >612nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085666((2S,3S,4R,5R)-5-{6-(2,2-Diphenyl-ethylamino)-2-[2-...)
Affinity DataKi:  672nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085660((2R,3R,4S,5R)-2-{6-[2-(3-Chloro-phenyl)-ethylamino...)
Affinity DataKi: >1.00E+3nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085661((2R,3R,4S,5R)-2-[6-Amino-2-((1R,2R)-2-hydroxy-cycl...)
Affinity DataKi:  1.47E+3nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085665((2S,3S,4R,5R)-5-[2-Cyclopentylamino-6-(2,2-dipheny...)
Affinity DataKi: >5.00E+3nMAssay Description:Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085659((2R,3R,4S,5R)-2-{2-Cyclohexylamino-6-[(naphthalen-...)
Affinity DataKi:  1.03E+4nMAssay Description:Agonistic activity against Adenosine A2A receptor on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50085659((2R,3R,4S,5R)-2-{2-Cyclohexylamino-6-[(naphthalen-...)
Affinity DataKi:  4.50E+4nMAssay Description:Agonistic activity against Adenosine A1 receptor on rat whole-brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50000091((6S,11R)-3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-...)
Affinity DataIC50:  5.90nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50229959(CHEMBL152663)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50229964(CHEMBL150615)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50229958(CHEMBL152720)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50229957(CHEMBL153459)
Affinity DataIC50:  90nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50229956(CHEMBL153616)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50229963(CHEMBL347719)
Affinity DataIC50:  130nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50229960(CHEMBL357705)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50000087(3-(2-Cyclopropylmethyl-octahydro-isoquinolin-4a-yl...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed