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Found 674 with Last Name = 'sinha' and Initial = 's'
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50434373(CHEMBL2386992)
Affinity DataKi:  42nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylcholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataKi:  56nMAssay Description:Non competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438537(CHEMBL2414861)
Affinity DataKi:  82nMAssay Description:Non competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438536(CHEMBL2414862)
Affinity DataKi:  246nMAssay Description:Non competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438536(CHEMBL2414862)
Affinity DataKi:  628nMAssay Description:Competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50212069(CHEMBL3912967)
Affinity DataKi:  720nMAssay Description:Uncompetitive inhibition of electric eel AChE using varying levels of acetylthiocholine iodide substrate preincubated for 20 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438541(CHEMBL2414858)
Affinity DataKi:  3.56E+3nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397031(CHEMBL2171190)
Affinity DataKi:  8.40E+3nMAssay Description:Competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki intercept using Histone H4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438539(CHEMBL2414860)
Affinity DataKi:  1.03E+4nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397030(CHEMBL2171189)
Affinity DataKi:  1.13E+4nMAssay Description:Competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki intercept using Histone H4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataKi:  1.25E+4nMAssay Description:Non competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438537(CHEMBL2414861)
Affinity DataKi:  1.68E+4nMAssay Description:Competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438538(CHEMBL2413097)
Affinity DataKi:  2.05E+4nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438542(CHEMBL2414857)
Affinity DataKi:  2.56E+4nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397030(CHEMBL2171189)
Affinity DataKi:  2.97E+4nMAssay Description:Non competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki slope using SAM preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438540(CHEMBL2414859)
Affinity DataKi:  3.55E+4nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438541(CHEMBL2414858)
Affinity DataKi:  7.27E+4nMAssay Description:Non competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438543(CHEMBL2414856)
Affinity DataKi:  8.86E+4nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438542(CHEMBL2414857)
Affinity DataKi:  2.12E+5nMAssay Description:Non competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397031(CHEMBL2171190)
Affinity DataKi: >2.57E+5nMAssay Description:Non competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki slope using SAM preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438539(CHEMBL2414860)
Affinity DataKi:  2.83E+5nMAssay Description:Competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438538(CHEMBL2413097)
Affinity DataKi:  4.46E+5nMAssay Description:Non competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438540(CHEMBL2414859)
Affinity DataKi:  6.24E+5nMAssay Description:Competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50438543(CHEMBL2414856)
Affinity DataKi:  6.85E+5nMAssay Description:Competitive inhibition of human serum BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16250(CHEMBL290001 | N-(tert-butoxycarbonyl)-L-valyl-N-[...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for its inhibitory activity against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for its inhibitory activity against human beta-Secretase (BACE)More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302846(CHEMBL570165 | benzyl 3-((2R,3S)-3-acetamido-4-(3,...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523558(CHEMBL4460401)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523567(CHEMBL4522729)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523566(CHEMBL4574382)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523569(CHEMBL4463796)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523568(CHEMBL4447493)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523560(CHEMBL4300203)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523561(CHEMBL4437104)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523562(CHEMBL4474072)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523563(CHEMBL4554438)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523564(CHEMBL4525849)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
TBA

Curated by ChEMBL
LigandPNGBDBM50523565(CHEMBL4542773)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM15797((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-i...)
Affinity DataIC50:  5nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 6(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM531207((R)-3-((3-chloro-2-hydroxyphenyl)amino)-4-((5,5-di...)
Affinity DataIC50:  6nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 6(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM531086((R)-6-chloro-3-((2-((2,2-dimethyl-1-phenylpropyl)a...)
Affinity DataIC50:  6nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328048(CHEMBL1257185)
Affinity DataIC50:  8nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 6(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM531125((R)-3-((2-((5,5-dimethyl-4,5,6,7-tetrahydrobenzofu...)
Affinity DataIC50:  8nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302862(CHEMBL566603 | N-((2S,3R)-4-((R)-3-(3-tert-butylph...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328038(CHEMBL1258467 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 6(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM531139(6-chloro-3-((2-((2,2-dimethyl-1-phenylbutyl)amino)...)
Affinity DataIC50:  9nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 6(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM531128((R)-6-chloro-3-((2-((5,5-dimethyl-4,5,6,7-tetrahyd...)
Affinity DataIC50:  12nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378120(CHEMBL609987)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
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