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Found 901 with Last Name = 'sliskovic' and Initial = 'dr'
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084286(2-(4'-Cyano-biphenyl-4-sulfonylamino)-N-hydroxy-3-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084286(2-(4'-Cyano-biphenyl-4-sulfonylamino)-N-hydroxy-3-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084291(2-(4'-Bromo-biphenyl-4-sulfonylamino)-4-phenylmeth...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084283((S)-3-methyl-2-(4'-methyl-biphenyl-4-sulfonylamino...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084283((S)-3-methyl-2-(4'-methyl-biphenyl-4-sulfonylamino...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084297(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-(3-phenyl-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084297(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-(3-phenyl-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50289025(CHEMBL164479 | N-(2,6-Diisopropyl-phenyl)-malonami...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in intestinal microsomes isolated from cholesterol fed rabbits (IAI)...More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084304((4'-Bromo-biphenyl-4-sulfonylamino)-acetic acid | ...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50289051(CHEMBL160103 | N-(2,6-Diisopropyl-phenyl)-malonami...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in intestinal microsomes isolated from cholesterol fed rabbits (IAI)...More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084286(2-(4'-Cyano-biphenyl-4-sulfonylamino)-N-hydroxy-3-...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084295(2-(4'-Cyano-biphenyl-4-sulfonylamino)-3-methyl-but...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50051461(CHEMBL264861 | N-(2,6-Diisopropyl-phenyl)-2-(2-dod...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 of liver microsomes isolated from cholesterol-fed rats.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084281(2-(4'-Bromo-biphenyl-4-sulfonylamino)-4-methyl-pen...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084290((S)-2-(4'-bromo-2'-fluoro-biphenyl-4-sulfonylamino...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084287((S)-2-(4'-cyano-biphenyl-4-sulfonylamino)-3-methyl...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50289024(CHEMBL422709 | N-(2,6-Diisopropyl-phenyl)-malonami...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in intestinal microsomes isolated from cholesterol fed rabbits (IAI)...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50051466(CHEMBL175982 | N-(2,6-Diisopropyl-phenyl)-2-(5-dod...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 of liver microsomes isolated from cholesterol-fed rats.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084281(2-(4'-Bromo-biphenyl-4-sulfonylamino)-4-methyl-pen...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084291(2-(4'-Bromo-biphenyl-4-sulfonylamino)-4-phenylmeth...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50006407(CHEMBL2367472 | Sodium; 7-[5-(4-fluoro-phenyl)-3-i...)
Affinity DataIC50:  7nMAssay Description:Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084295(2-(4'-Cyano-biphenyl-4-sulfonylamino)-3-methyl-but...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084298(4-Benzylsulfanyl-2-(4'-bromo-biphenyl-4-sulfonylam...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084300(2-(4'-Bromo-biphenyl-4-sulfonylamino)-5-(3-phenyl-...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50011032(5-(4-Fluoro-phenyl)-1-[2-(4-hydroxy-6-oxo-tetrahyd...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HMG-CoA reductase activity in partially purified rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50006407(CHEMBL2367472 | Sodium; 7-[5-(4-fluoro-phenyl)-3-i...)
Affinity DataIC50:  7nMAssay Description:Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50006409(CHEMBL2367478 | Sodium; 7-[5-(4-fluoro-phenyl)-3-i...)
Affinity DataIC50:  7nMAssay Description:Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50069886((2,6-Diisopropyl-phenylcarbamoyl)-methanesulfonic ...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of ACAT by incubation with [1-14C]-oleolyl-CoA and intestinal microsomes isolated from cholesterol-fed rabbits.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50069883((2,6-Diisopropyl-phenylcarbamoyl)-methanesulfonic ...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of ACAT by incubation with [1-14C]-oleolyl-CoA and intestinal microsomes isolated from cholesterol-fed rabbits.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084290((S)-2-(4'-bromo-2'-fluoro-biphenyl-4-sulfonylamino...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084302((S)-2-(4'-formyl-biphenyl-4-sulfonylamino)-3-methy...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063243(CHEMBL161499 | N-(2,6-Diisopropyl-phenyl)-2-pyridi...)
Affinity DataIC50:  8nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50039427(+/-(1-Methyl-Tridecyl)Thiocarbonyl-carbamic acid 2...)
Affinity DataIC50:  8nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibitory activity (IAI) was determined by measuring the incorporation of [1-14C]oleolyl-CoA in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50051460(2-(2-Dodecyl-2H-tetrazol-5-yl)-2-phenyl-N-(2,4,6-t...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase 1 from rabbit intestineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50084300(2-(4'-Bromo-biphenyl-4-sulfonylamino)-5-(3-phenyl-...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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