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Found 497 with Last Name = 'stevens' and Initial = 'am'
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.300nMAssay Description:50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50078668(3-(4-Phenylsulfanyl-benzenesulfonyl)-cyclohexaneth...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM11863(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Affinity DataIC50:  0.400nMAssay Description:50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.5nMAssay Description:50 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50076589(3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol | CH...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM11863(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Affinity DataIC50:  0.600nMAssay Description:50 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  0.75nMAssay Description:50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50078667(3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol | C...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50095222(CHEMBL83209 | N-Hydroxy-2-[4-(4-trifluoromethyl-ph...)
Affinity DataIC50:  1.30nMAssay Description:50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167837(3-Amino-N-((R)-sec-butyl)-5-{1-[(4-carbamimidoyl-b...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  2nMAssay Description:50 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50095218(CHEMBL310008 | N-Hydroxy-2-[4-(4-trifluoromethoxy-...)
Affinity DataIC50:  2nMAssay Description:50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50076593(3-(4-Phenylsulfanyl-benzenesulfonyl)-propane-1-thi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  2.90nMAssay Description:50 percent inhibition of human Matrix metalloprotease-1 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50095225(2-Fluoro-N-hydroxy-6-[4-(4-trifluoromethyl-phenoxy...)
Affinity DataIC50:  3.30nMAssay Description:50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50076589(3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol | CH...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-8 (hMMP-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167830(3-amino-N-[(2R)-butan-2-yl]-5-[1-({[(4-carbamimido...)
Affinity DataIC50:  6.20nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50078667(3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol | C...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-8 (hMMP-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167833(3-amino-N-[(2R)-butan-2-yl]-5-(1-{[({4-carbamimido...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50095225(2-Fluoro-N-hydroxy-6-[4-(4-trifluoromethyl-phenoxy...)
Affinity DataIC50:  12nMAssay Description:50 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167836(3-amino-N-[(2R)-butan-2-yl]-5-(1-{[({4-carbamimido...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14593(3-amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carb...)
Affinity DataIC50:  16nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14535(2-[6-(3-aminophenyl)-5-chloro-2-oxo-3-(propan-2-yl...)
Affinity DataIC50:  20nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50:  20nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167835(3-amino-N-[(2R)-butan-2-yl]-5-[1-({[(4-carbamimido...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167831(CHEMBL189166 | {2-[(2-{6-[3-Amino-5-((R)-sec-butyl...)
Affinity DataIC50:  21nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50078669(3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol | C...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167832(CHEMBL189597 | {2-[(2-{6-[3-Amino-5-((R)-sec-butyl...)
Affinity DataIC50:  23nMAssay Description:Inhibitory concentration against Coagulation factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  24nMAssay Description:50 percent inhibition of human Matrix metalloprotease-1 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  27nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against coagulation factor X.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50095222(CHEMBL83209 | N-Hydroxy-2-[4-(4-trifluoromethyl-ph...)
Affinity DataIC50:  28nMAssay Description:50 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity of the compound against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50095218(CHEMBL310008 | N-Hydroxy-2-[4-(4-trifluoromethoxy-...)
Affinity DataIC50:  33nMAssay Description:50 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50095224(CHEMBL94467 | N-Hydroxy-2-[4-(4-trifluoromethyl-be...)
Affinity DataIC50:  35nMAssay Description:50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50076593(3-(4-Phenylsulfanyl-benzenesulfonyl)-propane-1-thi...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-8 (hMMP-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14563(N-[(4-carbamimidoylphenyl)methyl]-2-{5-chloro-6-et...)
Affinity DataIC50: <40nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14520(N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[...)
Affinity DataIC50: <40nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14519(N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[...)
Affinity DataIC50: <40nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM50133093((R)-N-{(S)-1-[(S)-4-guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against thrombin (IIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14528(2-[6-(3-aminophenyl)-5-chloro-3-(ethylamino)-2-oxo...)
Affinity DataIC50:  40nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM50129981(2-(5-Chloro-2-oxo-3-phenethylamino-6-phenyl-2H-pyr...)
Affinity DataIC50: <40nMAssay Description:Inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  42nMAssay Description:Inhibition of tissue coagulation factor VIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  42nMAssay Description:Inhibitory activity against tissue coagulation factor VII.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50076592(3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol | CH...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50078668(3-(4-Phenylsulfanyl-benzenesulfonyl)-cyclohexaneth...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-8 (hMMP-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14537(2-[6-(3-aminophenyl)-5-chloro-2-oxo-3-(pentan-3-yl...)
Affinity DataIC50:  50nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14497(2-Pyridone 14b | N-[(4-carbamimidoylphenyl)methyl]...)
Affinity DataIC50:  52nMpH: 8.0 T: 2°CAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14562(N-[(4-carbamimidoylphenyl)methyl]-2-{5-chloro-6-me...)
Affinity DataIC50:  60nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14526(2-[6-(3-aminophenyl)-5-chloro-3-(methylamino)-2-ox...)
Affinity DataIC50:  60nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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