Compile Data Set for Download or QSAR
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Found 264 with Last Name = 'sylte' and Initial = 'i'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50063266(6-Nitro-2-piperazin-1-yl-quinoline | 6-nitroquipaz...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]-5HT from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105212(2-(4-Nonyl-piperazin-1-yl)-6-nitroquinoline (9))
Affinity DataKi:  1.80nM ΔG°:  -49.9kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105213(2-(4-Decyl-piperazin-1-yl)-6-nitroquinoline (10))
Affinity DataKi:  4.5nM ΔG°:  -47.6kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50315962(1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methylamin...)
Affinity DataKi:  8nMAssay Description:Binding affinity at 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301431(2-{4-[4-(5-Methoxy-1H-indol-3-yl)-piperidin-1-yl]-...)
Affinity DataKi:  10.4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM25876(4,4-dimethyl-1-{4-[4-(quinolin-2-yl)piperazin-1-yl...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321113(3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one |...)
Affinity DataKi:  11.5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105214(2-(4-Undecyl-piperazin-1-yl)-6-nitroquinoline (11))
Affinity DataKi:  12.6nM ΔG°:  -45.1kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM25869(2-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301442(4-(4-Fluoro-phenyl)-2-{4-[4-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  13.9nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301429(4-(4-Chloro-phenyl)-2-{4-[4-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  14.6nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50363815(CHEMBL1945686)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105215(2-(4-Dodecyl-piperazin-1-yl)-6-nitroquinoline (12))
Affinity DataKi:  16.1nM ΔG°:  -44.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301432(2-{4-[4-(1H-Indol-3-yl)-piperidin-1-yl]-butyl}-4-(...)
Affinity DataKi:  20.5nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105211(2-(4-Octyl-piperazin-1-yl)-6-nitroquinoline (8))
Affinity DataKi:  20.8nM ΔG°:  -43.8kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301446(2-{4-[4-(5-Methoxy-1H-indol-3-yl)-piperidin-1-yl]-...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105207(2-(4-Butyl-piperazin-1-yl)-6-nitroquinoline (4))
Affinity DataKi:  24nM ΔG°:  -43.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM25873(8-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301445(4-(2-Fluoro-phenyl)-2-{4-[4-(1H-indol-3-yl)-piperi...)
Affinity DataKi:  27.8nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-5HT from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50315963(1-(2-chlorobenzyloxy)-3-((2,3-dihydrobenzo[b][1,4]...)
Affinity DataKi:  36nMAssay Description:Binding affinity at 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301441(4-(2-Chloro-phenyl)-2-{4-[4-(1H-indol-3-yl)-piperi...)
Affinity DataKi:  36.2nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM25871(1-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM25875(8-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}-8-aza...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM25874(2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}-2,3-d...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301430(4-(2-Fluoro-phenyl)-2-{4-[4-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  45.6nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301428(2-{4-[4-(1H-Indol-3-yl)-piperidin-1-yl]-butyl}-4-p...)
Affinity DataKi:  48.3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301443(2-{4-[4-(5-Methoxy-1H-indol-3-yl)-piperidin-1-yl]-...)
Affinity DataKi:  51.7nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University Of Warsaw

Curated by ChEMBL
LigandPNGBDBM50301444(2-{4-[4-(1H-Indol-3-yl)-piperidin-1-yl]-butyl}-4-o...)
Affinity DataKi:  53.8nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105210(2-(4-Heptyl-piperazin-1-yl)-6-nitroquinoline (7))
Affinity DataKi:  54.1nM ΔG°:  -41.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301432(2-{4-[4-(1H-Indol-3-yl)-piperidin-1-yl]-butyl}-4-(...)
Affinity DataKi:  71.6nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105209(2-(4-Hexyl-piperazin-1-yl)-6-nitroquinoline (6))
Affinity DataKi:  72.9nM ΔG°:  -40.7kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301442(4-(4-Fluoro-phenyl)-2-{4-[4-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  76.1nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301428(2-{4-[4-(1H-Indol-3-yl)-piperidin-1-yl]-butyl}-4-p...)
Affinity DataKi:  76.7nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105208(2-(4-Pentyl-piperazin-1-yl)-6-nitroquinoline (5))
Affinity DataKi:  80.5nM ΔG°:  -40.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301431(2-{4-[4-(5-Methoxy-1H-indol-3-yl)-piperidin-1-yl]-...)
Affinity DataKi:  83.5nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM105205(2-(4-Ethyl-piperazin-1-yl)-6-nitroquinoline (2))
Affinity DataKi:  86.1nM ΔG°:  -40.3kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301441(4-(2-Chloro-phenyl)-2-{4-[4-(1H-indol-3-yl)-piperi...)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301445(4-(2-Fluoro-phenyl)-2-{4-[4-(1H-indol-3-yl)-piperi...)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301437(2-{4-[4-(2-Methyl-1H-indol-3-yl)-piperidin-1-yl]-b...)
Affinity DataKi:  115nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301433(4-(4-Fluoro-phenyl)-2-{4-[4-(2-methyl-1H-indol-3-y...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301444(2-{4-[4-(1H-Indol-3-yl)-piperidin-1-yl]-butyl}-4-o...)
Affinity DataKi:  124nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301443(2-{4-[4-(5-Methoxy-1H-indol-3-yl)-piperidin-1-yl]-...)
Affinity DataKi:  124nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301446(2-{4-[4-(5-Methoxy-1H-indol-3-yl)-piperidin-1-yl]-...)
Affinity DataKi:  136nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301430(4-(2-Fluoro-phenyl)-2-{4-[4-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  184nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50315962(1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methylamin...)
Affinity DataKi:  197nMAssay Description:Displacement of [3H]5CT from 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301436(4-(4-Methoxy-phenyl)-2-{4-[4-(2-methyl-1H-indol-3-...)
Affinity DataKi:  203nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50363810(CHEMBL1945681)
Affinity DataKi:  221nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Troms£

LigandPNGBDBM50301429(4-(4-Chloro-phenyl)-2-{4-[4-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  222nMAssay Description:Displacement of [3H]citalopram from SERT in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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