Found 310 with Last Name = 'tan' and Initial = 'ec' 
Affinity DataKi: 8.30nM IC50: 8.5nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 15nM IC50: 15nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 30nM IC50: 31nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 30nM IC50: 31nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 32nM IC50: 33nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 46nM IC50: 47nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 55nM IC50: 56nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 59nM IC50: 60nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 98nM IC50: 100nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 101nM IC50: 103nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
Affinity DataKi: 103nM IC50: 105nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 0.0560nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 0.970nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]ATP addition measured after 120 mins by Hotspot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of HDAC6 (unknown origin) using Arg-His-Lys-Lys(Ac) as substrate preincubated with enzyme followed by substrate addition for 2 hrs and mea...More data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
National University Of Singapore
Curated by ChEMBL
National University Of Singapore
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human JAK2 using poly(Glu:Tyr)(4:1) as substrate preincubated for 20 mins followed by [gamma33P]ATP addition measured after 120 mins by...More data for this Ligand-Target Pair
