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Found 334 with Last Name = 'timms' and Initial = 'g'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183152(CHEMBL206580 | N-(4-(trifluoromethyl)benzyl)-N-iso...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  0.110nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50451852(CHEMBL1159649)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183124(CHEMBL381373 | N-(3-(trifluoromethyl)benzyl)-N-iso...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183122(4-((isobutyl(piperidin-4-yl)amino)methyl)benzonitr...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145355(1-{2-[4-(6,7-Dichloro-1H-indol-3-yl)-3,6-dihydro-2...)
Affinity DataKi:  0.280nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145343(1-{2-[4-(6-Fluoro-benzofuran-3-yl)-3,6-dihydro-2H-...)
Affinity DataKi:  0.290nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183121(CHEMBL441358 | N-(4-fluoro-2-(trifluoromethyl)benz...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50366907(CHEMBL1169435)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145356(1-{2-[4-(6,7-Difluoro-1H-indol-3-yl)-3,6-dihydro-2...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145342(1-{2-[4-(6-Chloro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.380nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183126(CHEMBL207374 | N-(2,4-dimethylbenzyl)-N-isobutylpi...)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183177(4-((4-fluoro-2-(trifluoromethyl)benzyl)(piperidin-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183141(3-((4-fluoro-2-(trifluoromethyl)benzyl)(piperidin-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183154(CHEMBL207067 | CHEMBL207214 | N-(4-fluoro-2-(trifl...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183136(CHEMBL208533 | N-(2-chloro-3-(trifluoromethyl)benz...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183137(1-(2-cyclohexyl-4-methylpentyl)-3-ethynylbenzene f...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145354(1-{2-[4-(6-Fluoro-1H-indazol-3-yl)-3,6-dihydro-2H-...)
Affinity DataKi:  0.5nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145350(1-{2-[4-(6-Fluoro-1-methyl-1H-indazol-3-yl)-3,6-di...)
Affinity DataKi:  0.540nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183135(4-((2-(trifluoromethyl)benzyl)(piperidin-4-yl)amin...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183173(4-((4-fluoro-2-(trifluoromethyl)benzyl)(piperidin-...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145349(1-{2-[4-(7-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.760nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145338(1-{2-[(S)-4-(6-Fluoro-1H-indol-3-yl)-2-methyl-pipe...)
Affinity DataKi:  0.780nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210638(1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methylpipe...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183154(CHEMBL207067 | CHEMBL207214 | N-(4-fluoro-2-(trifl...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183134(CHEMBL207854 | N-(4-fluoro-2-(trifluoromethyl)benz...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210642((S)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methylp...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]GR125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183176(CHEMBL207860 | N-(2,4-dichlorobenzyl)-N-isobutylpi...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145344(1-{2-[4-(6-Fluoro-1-methyl-1H-indol-3-yl)-3,6-dihy...)
Affinity DataKi:  0.980nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145346(1-{2-[4-(6-Trifluoromethyl-1H-indol-3-yl)-3,6-dihy...)
Affinity DataKi:  0.990nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183166(CHEMBL380191 | isobutyl-(4-methyl-benzyl)-piperidi...)
Affinity DataKi:  0.990nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210635((S)-1-(2-(4-(6-cyanonaphthalen-1-yl)piperazin-1-yl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]GR125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145336(1-{2-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-3,6-dihyd...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183165(CHEMBL438059 | N-(2-(methylthio)benzyl)-N-isobutyl...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183147(CHEMBL207755 | N-(4-fluoro-2-(trifluoromethyl)benz...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145352(1-{2-[3-(6-Fluoro-1H-indol-3-yl)-pyrrolidin-1-yl]-...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity determined against alpha-1 adrenergic receptor in rat cortex membranes using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183160(2-((isobutyl(piperidin-4-yl)amino)methyl)benzonitr...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210637((1S)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methy...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183146(CHEMBL426316 | N-(4-fluoro-2-(trifluoromethyl)benz...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210640((1R)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methyl...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183144(CHEMBL207810 | N-(5-fluoro-2-methoxybenzyl)-N-isob...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183138(CHEMBL380890 | N-(2-(trifluoromethyl)benzyl)-N-iso...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183151(CHEMBL208251 | N-(2-chlorobenzyl)-N-isobutylpiperi...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]nisoxetine from NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183129(CHEMBL377882 | N-(2-(trifluoromethyl)benzyl)-N-(cy...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183133(CHEMBL207023 | N-(2-(trifluoromethyl)benzyl)-N-but...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183127(CHEMBL208067 | isobutyl-(2-methyl-benzyl)-piperidi...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50183151(CHEMBL208251 | N-(2-chlorobenzyl)-N-isobutylpiperi...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145341(1-{2-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  1.60nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50451852(CHEMBL1159649)
Affinity DataKi:  1.70nMAssay Description:Binding affinity determined against alpha-1 adrenergic receptor in rat cortex membranes using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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