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Found 208 with Last Name = 'tounge' and Initial = 'ba'
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128034(4-[2-(5-{2-[2-(2-Amino-4-carboxy-butyrylamino)-4-m...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128033(((S)-1-{1-[(S)-4-(1-Benzylcarbamoyl-2-methyl-propy...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318123((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17-t...)
Affinity DataKi:  5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318133((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17,2...)
Affinity DataKi:  5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128035(((S)-1-{1-[(S)-4-(1-Benzylcarbamoyl-2-methyl-propy...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318125((14S)-16-amino-10-cyclohexyl-14-(propan-2-yl)-2-ox...)
Affinity DataKi:  8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128038(((S)-1-{1-[(S)-4-(1-Benzylcarbamoyl-2-methyl-propy...)
Affinity DataKi:  8nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318131((14S)-16-amino-10,14-dicyclohexyl-20-fluoro-2-oxa-...)
Affinity DataKi:  8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128042(((S)-1-{1-[(S)-4-(1-Benzylcarbamoyl-2-methyl-propy...)
Affinity DataKi:  9.40nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318132((14S)-16-amino-10,14-dicyclohexyl-20-methoxy-2-oxa...)
Affinity DataKi:  12nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318124((14S)-16-amino-14-cyclohexyl-10-(oxan-4-yl)-2-oxa-...)
Affinity DataKi:  17nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318129(4-[(14S)-16-amino-14-cyclohexyl-11-oxo-2-oxa-10,15...)
Affinity DataKi:  20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318128((14S)-16-amino-10-(oxan-4-yl)-14-(propan-2-yl)-2-o...)
Affinity DataKi:  22nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50273022(1-(2,3-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM17785(2-aminoquinazoline, 3 | 4-(2-amino-6-phenoxy-3,4-d...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318127((15S)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataKi:  31nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50273058(CHEMBL457186 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128032(((S)-1-{1-[(S)-4-(1-Benzylcarbamoyl-2-methyl-propy...)
Affinity DataKi:  50nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50273024(1-(3,4-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128040(((S)-1-{1-[(S)-4-(1-Benzylcarbamoyl-ethylcarbamoyl...)
Affinity DataKi:  61nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272980(CHEMBL455958 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272856(CHEMBL497485 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272979(CHEMBL509968 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272900(1-(2-bromophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)
Affinity DataKi:  71nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272982(1-(2-isopropylphenyl)-N-(3-oxo-3,4-dihydro-2H-benz...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272983(1-(2-bromo-3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H...)
Affinity DataKi:  81nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272858(1-(3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272899(1-(2-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272859(1-(3-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataKi:  97nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50273021(1-(3-chloro-2-methylphenyl)-N-(3-oxo-3,4-dihydro-2...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272981(1-(2-ethylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50273057(1-(3,5-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  137nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50273023(1-(4-tert-butylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  142nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM17784(2-aminoquinazoline, 2 | 3-[(2-amino-6-phenoxy-3,4-...)
Affinity DataKi:  158nM ΔG°:  -38.4kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318126((15R)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataKi:  186nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272897(CHEMBL455926 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)
Affinity DataKi:  225nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50273025(1-(3,4-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  314nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM17783(2-aminoquinazoline, 1 | 3-(2-amino-6-benzoyl-3,4-d...)
Affinity DataKi:  900nM ΔG°:  -34.2kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50318130(4-[(14S)-16-amino-14-cyclohexyl-11-oxo-2-oxa-10,15...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128037(CHEMBL302833 | {1-[4-(1-Benzylcarbamoyl-2-methyl-p...)
Affinity DataKi:  1.13E+3nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50272898(1-(2-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataKi:  1.47E+3nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128044(CHEMBL305381 | {1-[4-(1-Benzylcarbamoyl-2-methyl-p...)
Affinity DataKi:  3.13E+3nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128039(CHEMBL66595 | {1-[(S)-4-(1-Benzylcarbamoyl-2-methy...)
Affinity DataKi:  5.81E+3nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128041((1-{1-[4-(1-Benzylcarbamoyl-2-methyl-propylcarbamo...)
Affinity DataKi:  1.05E+4nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50128036(CHEMBL431917 | {1-[4-(1-Benzylcarbamoyl-ethylcarba...)
Affinity DataKi:  2.24E+4nMAssay Description:Binding affinity for human brain memapsin 2 beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50104600((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of human Biotinylated Fg binding to immobilized Alpha II beta-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50153559(3-(2-Methyl-pyrimidin-5-yl)-4-[1-(3-5,6,7,8-tetrah...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human vitronectin binding to immobilized Alpha v beta-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50153566(3-Pyridin-3-yl-4-[1-(3-5,6,7,8-tetrahydro-[1,8]nap...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human vitronectin binding to immobilized Alpha v beta-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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