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Found 2616 with Last Name = 'vin' and Initial = 'v'
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485941(CHEMBL2181004)
Affinity DataKi:  0.0460nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485945(CHEMBL2181003)
Affinity DataKi:  0.0585nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485942(CHEMBL2181002)
Affinity DataKi:  0.0637nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485950(CHEMBL2181009)
Affinity DataKi:  0.122nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485944(CHEMBL2181006)
Affinity DataKi:  0.127nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485943(CHEMBL2181001)
Affinity DataKi:  0.131nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485946(CHEMBL2181000)
Affinity DataKi:  0.143nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000041((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...)
Affinity DataKi:  0.170nMAssay Description:In vitro inhibitory activity against human NK1 receptor was determinedMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485947(CHEMBL2181008)
Affinity DataKi:  0.183nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485949(CHEMBL2180999)
Affinity DataKi:  0.198nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485948(CHEMBL2181007)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485940(CHEMBL2181005)
Affinity DataKi:  0.367nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000041((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...)
Affinity DataKi:  0.794nMAssay Description:Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50014846((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50131550((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  6.20nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341987((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  26nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataKi:  29nMAssay Description:Inhibition of human Cdc25AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50213785(CHEMBL91475)
Affinity DataKi:  40nMAssay Description:Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  44nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataKi:  89nMAssay Description:Inhibition of human Cdc25CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataKi:  95nMAssay Description:Inhibition of human Cdc25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341982(5-(2-cyclohexyl-4-((1-(6-(4-fluoro-2-methylphenyls...)
Affinity DataKi:  150nMAssay Description:Inhibition of Mycobacterium tuberculosis ptpBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341985(CHEMBL1765366)
Affinity DataKi:  250nMAssay Description:Inhibition of Mycobacterium tuberculosis ptpBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50342004(4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-...)
Affinity DataKi:  700nMAssay Description:Inhibition of SHP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50213784(CHEMBL91840)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341977(2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic a...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis ptpAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341977(2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic a...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Institute For Medical Research And Occupational Health

Curated by ChEMBL
LigandPNGBDBM50395543(CHEMBL2164778)
Affinity DataKi:  3.90E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Institute For Medical Research And Occupational Health

Curated by ChEMBL
LigandPNGBDBM50395543(CHEMBL2164778)
Affinity DataKi:  7.10E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Institute For Medical Research And Occupational Health

Curated by ChEMBL
LigandPNGBDBM50395542(CHEMBL2164779)
Affinity DataKi:  1.20E+6nMAssay Description:Inhibition of human AChE using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Institute For Medical Research And Occupational Health

Curated by ChEMBL
LigandPNGBDBM50395542(CHEMBL2164779)
Affinity DataKi:  1.40E+6nMAssay Description:Inhibition of human AChE using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396227(6-[5-Bromo-6-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-pyr...)
Affinity DataIC50:  0.0200nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396236(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Affinity DataIC50:  0.0200nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396194(6-(5-Bromo-6-methoxy-pyridin-2-ylmethyl)-5-methyl-...)
Affinity DataIC50:  0.0220nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396220(6-(5-Bromo-6-morpholin-4-yl-pyridin-2-ylmethyl)-5-...)
Affinity DataIC50:  0.0260nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396205(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Affinity DataIC50:  0.0260nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396246(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Affinity DataIC50:  0.0270nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396239(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Affinity DataIC50:  0.0270nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50548078(CHEMBL4746798)
Affinity DataIC50:  0.0280nMAssay Description:Each assay plate contains wells with vehicle controls (1% DMSO) for the measurement of non-inhibited transfer reaction (=100% Ctl) and wells with 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396118(6-(5,6-Dibromo-pyridin-2-ylmethyl)-5-methyl-[1,2,5...)
Affinity DataIC50:  0.0300nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396219(1-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Affinity DataIC50:  0.0330nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396233(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Affinity DataIC50:  0.0330nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM524090(6-{[3-(2-Fluoropyridin-3-yl)-1H-pyrazol-1-yl]methy...)
Affinity DataIC50:  0.0340nMAssay Description:Each assay plate contains wells with vehicle controls (1% DMSO) for the measurement of non-inhibited transfer reaction (=100% Ctl) and wells with 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396197(6-[5-Bromo-6-(2-fluoro-ethoxy)-pyridin-2-ylmethyl]...)
Affinity DataIC50:  0.0340nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM524080(6-{[3-(2-Fluorophenyl)-1H-pyrazol-1-yl]methyl}-5-m...)
Affinity DataIC50:  0.0350nMAssay Description:Each assay plate contains wells with vehicle controls (1% DMSO) for the measurement of non-inhibited transfer reaction (=100% Ctl) and wells with 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396222(6-(5-Bromo-6-cyclopropylamino-pyridin-2-ylmethyl)-...)
Affinity DataIC50:  0.0380nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396112(6-(6-Bromo-5-difluoromethoxy-pyridin-2-ylmethyl)-5...)
Affinity DataIC50:  0.0380nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM524098(US11136337, Example 4.9)
Affinity DataIC50:  0.0400nMAssay Description:Each assay plate contains wells with vehicle controls (1% DMSO) for the measurement of non-inhibited transfer reaction (=100% Ctl) and wells with 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM396218(6-{5-Bromo-6-[(3-methyl-oxetan-3-ylmethyl)-amino]-...)
Affinity DataIC50:  0.0450nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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