Compile Data Set for Download or QSAR
maximum 50k data
Found 419 with Last Name = 'walker' and Initial = 'dm'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077930(5-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077933(4-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077934(3-Benzo[1,3]dioxol-5-yl-4-[3,4-dimethoxy-5-(2-morp...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077935(CHEMBL308646 | {5-[4-Benzo[1,3]dioxol-5-yl-2-hydro...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077936(4-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataIC50:  0.300nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077946(5-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034263(CHEMBL25438 | PD-156707 | Sodium; (Z)-2-benzo[1,3]...)
Affinity DataIC50:  0.310nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50290981(CHEMBL319452 | PD-163140 | [4-Benzo[1,3]dioxol-5-y...)
Affinity DataIC50:  0.350nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataIC50:  0.370nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077944(CHEMBL408055 | Sodium; 3-{5-[4-benzo[1,3]dioxol-5-...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50290983(3-[4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-5-...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50290980(2-[4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-5-...)
Affinity DataIC50:  0.5nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50290984(2-[4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-5-...)
Affinity DataIC50:  0.600nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077941(3-Benzo[1,3]dioxol-5-yl-4-[3,4-dimethoxy-5-(3-morp...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50290982(Allyl-carbamic acid 4-benzo[1,3]dioxol-5-yl-2-(4-m...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077943(3-Benzo[1,3]dioxol-5-yl-4-[3-(3-dimethylamino-prop...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50369268(CHEMBL1790519)
Affinity DataIC50:  1nMAssay Description:Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034259(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-ben...)
Affinity DataIC50:  1.80nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50290979(((S)-1-Naphthalen-1-yl-ethyl)-carbamic acid 4-benz...)
Affinity DataIC50:  2nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287200(1-Benzo[1,3]dioxol-5-ylmethyl-5,6-dimethoxy-3-(3,4...)
Affinity DataIC50:  2nMAssay Description:Affinity for human endothelin A receptor expressed in Ltk cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50290979(((S)-1-Naphthalen-1-yl-ethyl)-carbamic acid 4-benz...)
Affinity DataIC50:  2nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077938(3-Benzo[1,3]dioxol-5-yl-4-{3,4-dimethoxy-5-[3-(4-m...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077947(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034269(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-3-m...)
Affinity DataIC50:  2.40nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077945(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-dimethylamino-etho...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032181(2-{1-[1-(2-carboxy-1-{1-[10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50:  3.5nMAssay Description:Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077942(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032181(2-{1-[1-(2-carboxy-1-{1-[10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032175((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  4nMAssay Description:Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287200(1-Benzo[1,3]dioxol-5-ylmethyl-5,6-dimethoxy-3-(3,4...)
Affinity DataIC50:  4.60nMAssay Description:Affinity for human endothelin A receptor expressed in Ltk cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032181(2-{1-[1-(2-carboxy-1-{1-[10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287183(1-Benzo[1,3]dioxol-5-ylmethyl-3-(benzo[1,3]dioxol-...)
Affinity DataIC50:  5nMAssay Description:Affinity for human endothelin A receptor expressed in Ltk cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034269(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-3-m...)
Affinity DataIC50:  6nMAssay Description:Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50287190(5-Benzo[1,3]dioxol-5-ylmethyl-7-(3,4,5-trimethoxy-...)
Affinity DataIC50:  7nMAssay Description:Affinity for human endothelin A receptor expressed in Ltk cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50057155((Z)-2-Benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-...)
Affinity DataIC50:  7.40nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034256(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-me...)
Affinity DataIC50:  7.40nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077931(CHEMBL70017 | {5-[4-Benzo[1,3]dioxol-5-yl-2-hydrox...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50290986(CHEMBL320183 | Methyl-carbamic acid 4-benzo[1,3]di...)
Affinity DataIC50:  9nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034259(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-4-(4-methoxy-ben...)
Affinity DataIC50:  9nMAssay Description:Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032175((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  10nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077939(3-Benzo[1,3]dioxol-5-yl-4-[3,5-bis-(2-morpholin-4-...)
Affinity DataIC50: >10nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077937(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032216((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  12nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034270(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-me...)
Affinity DataIC50:  12nMAssay Description:Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077928(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034270(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-me...)
Affinity DataIC50:  12nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032193((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  13nMAssay Description:Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032175((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  14nMAssay Description:Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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