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Found 326 with Last Name = 'wallace' and Initial = 'aa'
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292202(CHEMBL382542 | N-(2-Aminomethyl-5-chloro-benzyl)-2...)
Affinity DataKi:  0.00100nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147818((2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-...)
Affinity DataKi:  0.00140nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147824(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.00150nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292203(CHEMBL196030 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.00200nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147793(CHEMBL323583 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.0130nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337452(2-(4-chloro-2-((2-(6-methyl-2-oxo-3-(2-(pyridin-2-...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147788(CHEMBL103874 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.0180nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147809(CHEMBL103342 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.0330nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292196(CHEMBL195366 | N-(2-Aminomethyl-5-chloro-benzyl)-2...)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123490(CHEMBL143418 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.0420nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147812(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292200(2-[3-Chloro-6-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292189(2-[2-(3-Chloro-benzylamino)-2-hydroxy-ethyl]-6-(2,...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147801(CHEMBL102122 | N-(5-Chloro-2-[1,2,4]triazol-1-yl-b...)
Affinity DataKi:  0.0850nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126304(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.0870nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147821(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.0960nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123504(CHEMBL142546 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337453(2-(4-chloro-2-((2-(6-methyl-2-oxo-3-(2-(pyridin-2-...)
Affinity DataKi:  0.125nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147822(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292201(CHEMBL372367 | N-(5-Chloro-2-tetrazol-1-yl-benzyl)...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147810(CHEMBL100854 | N-(5-Chloro-2-[1,2,4]triazol-1-yl-b...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126303(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126309(CHEMBL29744 | N-(3-Bromo-benzyl)-2-{6-chloro-3-[2,...)
Affinity DataKi:  0.190nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126493(2-(3-Amino-4-cyclobutylmethanesulfonyl-6-methyl-2-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147826(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  0.210nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292187(2-[3-Cyano-6-(2,2-difluoro-2-pyridin-2-yl-ethylami...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50370389(CHEMBL1201843)
Affinity DataKi:  0.240nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126300(CHEMBL25845 | N-(3-Chloro-benzyl)-2-{6-chloro-3-[2...)
Affinity DataKi:  0.260nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337483(CHEMBL1682777 | N1-(5-chloro-2-(1H-tetrazol-1-yl)b...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337479(CHEMBL1682781 | N-(5-chloro-2-(1H-tetrazol-1-yl)be...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150298((S)-1-((R)-2-Cyclohexyl-2-hydroxy-acetyl)-pyrrolid...)
Affinity DataKi:  0.270nMAssay Description:Inhibition constant against human ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123496(CHEMBL143138 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.270nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337470(2-(2-(5-chloro-4-(2-(5-chloro-2-(2,2,2-trifluoroet...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147799(2-[(S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolid...)
Affinity DataKi:  0.330nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50371333(CHEMBL256671)
Affinity DataKi:  0.350nMAssay Description:Binding affinity to human bradikinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147816(2-[(S)-1-((R)-2-Amino-3-pyridin-2-yl-propionyl)-py...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123486(2-[6-Cyano-3-(2,2-difluoro-2-pyridin-2-yl-ethylami...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292195(CHEMBL373270 | N-(2-Aminomethyl-benzyl)-2-[3-chlor...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292192(1-(3-Chloro-benzylamino)-2-[3-chloro-6-(2,2-difluo...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50371320(CHEMBL271283)
Affinity DataKi:  0.430nMAssay Description:Binding affinity to human bradikinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147820(CHEMBL102174 | N-(3-Chloro-benzyl)-2-[6-chloro-3-(...)
Affinity DataKi:  0.440nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50147790(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.450nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292186(CHEMBL197464 | N-[2-((R)-1-Amino-ethyl)-5-chloro-b...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50292205(CHEMBL195313 | N-[1-(2-Aminomethyl-5-chloro-phenyl...)
Affinity DataKi:  0.480nMAssay Description:Binding affinity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164264((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  0.490nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337461(CHEMBL1682756 | N-(5-chloro-2-(2,2,2-trifluoroetho...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150297((S)-1-(2-Hydroxy-acetyl)-pyrrolidine-2-carboxylic ...)
Affinity DataKi:  0.5nMAssay Description:Inhibition constant against human ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123479(CHEMBL143008 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.540nMAssay Description:Inhibitory constant against thrombin (IIa) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164256((S)-1-(2-Hydroxy-2,2-diphenyl-acetyl)-pyrrolidine-...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of coagulation factor II (thrombin) of humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50371332(CHEMBL258324)
Affinity DataKi:  0.590nMAssay Description:Binding affinity to human bradikinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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