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Found 208 with Last Name = 'wallace' and Initial = 'l'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136685(CHEMBL337822 | [3-Furan-2-yl-3-(naphthalen-1-yloxy...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210638(1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methylpipe...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  0.800nMAssay Description:Ability to inhibit the reuptake of 5-HT at human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210642((S)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methylp...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]GR125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136672(CHEMBL342716 | [3-(4-Fluoro-phenyl)-3-(naphthalen-...)
Affinity DataKi:  0.950nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210635((S)-1-(2-(4-(6-cyanonaphthalen-1-yl)piperazin-1-yl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]GR125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136683(CHEMBL142028 | Methyl-[3-(naphthalen-1-yloxy)-3-th...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173945(CHEMBL195190 | [2,2']Bithiophenyl-5-carboxylic aci...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  1.20nMAssay Description:Compound was tested for inhibitory activity against the binding of [3H]-spiperone to Dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210640((1R)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methyl...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210637((1S)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methy...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173953(CHEMBL364069 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136680(CHEMBL424660 | N-methyl-3-(1-naphthyloxy)-3-(2-thi...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173956(CHEMBL370535 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210640((1R)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methyl...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]GR125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136679(CHEMBL141741 | Methyl-[3-(naphthalen-1-yloxy)-3-o-...)
Affinity DataKi:  2nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210641((S)-1-(2-((S)-4-(6-fluoronaphthalen-2-yl)-2-methyl...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136689(CHEMBL141114 | Methyl-[3-(naphthalen-1-yloxy)-3-p-...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210642((S)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methylp...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136690(CHEMBL337791 | [3-(3-Methoxy-phenyl)-3-(naphthalen...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136691(CHEMBL139106 | [3-(2-Methoxy-phenyl)-3-(naphthalen...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136682(CHEMBL141681 | Methyl-[3-(naphthalen-1-yloxy)-3-ph...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210633((S)-1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methyl...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173944(5'-phenyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173942(CHEMBL195329 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173943(5-Phenyl-thiophene-2-carboxylic acid (1-aza-bicycl...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136686(CHEMBL415244 | [3-(4-Methoxy-phenyl)-3-(naphthalen...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136688(CHEMBL139245 | [3-(4-Chloro-phenyl)-3-(naphthalen-...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136675(CHEMBL139277 | Methyl-[3-(naphthalen-1-yloxy)-3-m-...)
Affinity DataKi:  4nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136676(CHEMBL139168 | [3-(4-Bromo-phenyl)-3-(naphthalen-1...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173947(5-Phenyl-isothiazole-3-carboxylic acid (1-aza-bicy...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50210638(1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methylpipe...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]raclopride from dopamine D2 receptor in rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Mus musculus (Mouse))
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50016778(1-Ethyl-2-[(2-methoxy-5-sulfamoyl-benzoylamino)-me...)
Affinity DataKi:  5.20nMAssay Description:Compound was tested for its ability to displace [3H]- spiperone from D2 binding site in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM11638(CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl...)
Affinity DataKi:  5.5nMAssay Description:Compound was tested for its ability to displace [3H]- spiperone from Dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210635((S)-1-(2-(4-(6-cyanonaphthalen-1-yl)piperazin-1-yl...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136670(CHEMBL138031 | Methyl-[3-(naphthalen-1-yloxy)-3-th...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50170587(5-Pyridin-2-yl-thiophene-2-carboxylic acid (1-aza-...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210633((S)-1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methyl...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]GR125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  7.30nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210639((R)-1-(2-((R)-4-(6-fluoronaphthalen-1-yl)-2-methyl...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  7.5nMAssay Description:Ability to inhibit the reuptake of NE at human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136678(CHEMBL337798 | [3-(3-Bromo-phenyl)-3-(naphthalen-1...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]GR125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210636((S)-1-(2-(4-(6-fluoronaphthalen-2-yl)piperazin-1-y...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173941(5'N-(3-pyridylmethyl)-(2'R)-spiro[4-azabicyclo[2.2...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210634((1R)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methy...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]citalopram from human 5HT transpoter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210636((S)-1-(2-(4-(6-fluoronaphthalen-2-yl)piperazin-1-y...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]GR125743 from human 5HT1D expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136677(CHEMBL334929 | Methyl-[3-(naphthalen-1-yloxy)-3-(2...)
Affinity DataKi:  10nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50210634((1R)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methy...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A expressed in LM(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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